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Öğe Current compherensive approach to Covid-19(Duvar Kitapevi, 1/06/2022) Koksoy, Hale; Rağbetli, Murat Çetin; Alp, Harun; Ecesoy, Hilal; Basaran, Aynur; Kaya, Aysenur; Sahin, Ali; Bekci, Taha Tahir; Yesildag, Ahmet; Ecesoy, Volkan; Kocabas, Rahim; Karaburgu, Sülbiye; Ay, Mehmet Emre; Dulger, Ozlem; Osmanoglu, Omer Usame; Serin, Aliye Nigar; Ragbetli, Cennet; Kose, Fulya; Atik, Dilek; Kılıc, Nuray; Mustu, Mehmet; Alkan, Gulsum; Arıcı, Hasan; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, HaleThis book, prepared by our Karamanoglu Mehmetbey and other faculty members by adding their current experiences during the pandemic process, is one of the leading scientific publications about the COVID-19 pandemic.Öğe Current multidisciplinary approach to diabetes mellitus occurrence mechanism(Nobel Tıp Bookstores, 30/09/2023) Rağbetli, Murat Çetin; Kaya, Aysenur; Keskin, Seda; Kıran, Tugba Raika; Karabulut Bay, Aysun; Unal, Mustafa; Uguz, A. Cihangir; Kocaman, Süheyla; Dasdelen, Dervis; Koksoy, Hale; Kocabas, Rahim; Ecesoy, Volkan; Arıcı, Hasan; Osmanoglu, Omer Usame; Irgat İncedal, Serap; Gumus, Hale Hatice; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, HaleThis book aims to provide a current and comprehensive perspective on Diabetes mellitus, a valuable subject in the field of basic sciences. Diabetes mellitus is a chronic disease that affects millions of people worldwide and has become an increasingly serious health problem. This book examines the underlying mechanisms and causes of diabetes using the disciplines of basic sciences. The content of the book begins with fundamental information such as the definition, classification, histopathological mechanisms, and epidemiology of diabetes. It also includes interesting sections on current technologies and the use of artificial intelligence in the field of diabetes. Additionally, the book extensively discusses how genetic predisposition, environmental factors, and lifestyle choices affect the risk of diabetes. This comprehensive evaluation of diabetes from the perspective of basic sciences provides important insights into the development and progression of the disease.Öğe Examining sirtuin-1 levels and ınflammation markers in behcet’s disease: A pilot study(Turkish League Against Rheumatism (TLAR), June 2025) Ecesoy, Volkan; Arıcı, Hasan; Pınar Ateş, Fadime; Ömer Osmanoğlu, UsameInterleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α are the principal proinflammatory cytokines that contribute to inflammatory activity in patients with Behcet’s disease (BD). The aim was to assess circulatory Sirtuin-1 (SIRT1) levels in BD and evaluate potential relationships with disease activity scores and several inflammatory markers in order to investigate its potential as a disease activity marker. Materials and Methods: Forty patients with BD and 40 healthy volunteers matched for age and sex were enrolled. Demographic and clinical data were recorded, including family history of BD, smoking and alcohol consumption, height, weight, and comorbidities. Patients with BD were classified with respect to disease activity, treatments, and organ involvement. Disease activity was determined and categorized using the Behcet Disease Current Activity Form (BDCAF). Inflammation markers and SIRT1 levels were studied in fasting blood samples. Results: C-reactive protein, IL-6, and TNF-α values were found to be significantly higher in patients with BD compared to controls, largely irrespective of disease activity. SIRT1 results were similar in patients and controls. SIRT1 measurements again showed no differences when compared across disease activity groups and patients with and without TNF-α blockade treatment. However, patients with concurrent vascular and ocular involvement appeared to have significantly lower SIRT1 levels when compared to patients with only ocular involvement. Conclusion: SIRT1 levels in the circulation of patients with BD appear to be similar to controls, regardless of disease activity or anti-TNF-α treatment; however, SIRT1 concentrations may be associated with vascular injury as demonstrated by significantly lower SIRT1 levels in patients with vascular + ocular involvement compared to those with only skin or ocular involvement.Öğe Is procalcitonin elevation always an indicator of bacterial infection?(Turkish League Against Rheumatism (TLAR), 2024) Ecesoy, Volkan; Ecesoy, HilalAdult-onset Still’s disease is a systemic inflammatory disorder with fever, arthritis, and rash.[1] Although the etiology is not known, some viral (rubella, echovirus, Epstein-Barr, cytomegalovirus) and bacterial (Yersinia enterocolitica, Mycoplasma pneumoniae) factors have been accused.[2] It is difficult to diagnose and can be diagnosed by excluding other causes, such as malignancy, collagen tissue disease, and infection. It is very difficult to distinguish from bacterial infections, especially since it is accompanied by fever and rashes, elevated C-reactive protein (CRP), erythrocyte sedimentation rate, and leukocytosis.












