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Öğe Insights on the predictive role of aortic knob calcification in post-TAVI pacemaker implantation(Termedia Publishing House Ltd., 2025) Süygün, HakanInsights on the predictive role of aortic knob calcification in post-TAVI pacemaker implantationÖğe Doomscrolling and social media addiction in adolescents: a two-wave longitudinal study(Taylor and Francis Ltd., 2025) Akat, Muhammed; Hamarta, ErdalIn recent years, various traumatic events such as pandemics, earthquakes, wars, and migration have occurred worldwide. Negative news and content related to these events can be easily accessed on social media, leading to the concept of doomscrolling. Doomscrolling is a recent phenomenon in mental health research and has not yet been sufficiently studied. Therefore, in this study, the longitudinal relationship between social media addiction and doomscrolling was examined. In this study, data were collected at two time points, time 1 (T1) and time 2 (T2), separated by a two-month interval. The study sample comprised 301 adolescents (48.5% female; 51.5% male) from 20 cities in Turkey. Participants were aged 12 to 19 (Mage = 15.55, SD = 1.09). The study employed a Cross-lagged path analytic model for the analysis. The analyses revealed positive and significant relationships between social media addiction and doomscrolling. It was concluded that at T1, addiction to social media had a positive correlation with doomscrolling at T2. Furthermore, the analysis revealed that social media addiction at T1 had a positive correlation with social media addiction at T2. However, the study found that engaging in doomscrolling at T1 did not significantly predict the development of social media addiction at T2. In conclusion, adolescents’ social media addiction levels increase the risk of doomscrolling. These results demonstrate the importance of interventions that include social media addiction in the prevention and treatment of doomscrolling. Mental health professionals can provide interventions that include healthy social media use skills in adolescents to prevent doomscrolling.Öğe Antibacterial abilities of Vancomycin interactions in PDEGMA brushes fabricated by interface-mediated PET-RAFT polymerization on implant surfaces(Royal Society of Chemistry, 29 May 2025) Abbaslı, Ayla; Türkmen, Kübra Erkan; Eren, Dilek Çimen; Yıldırım, ErtanThe proliferation of pathogenic bacteria and biofilm formation on implantable material surfaces causes negative results in many medical treatments and infections. Despite the measures taken against unwanted bacteria with modern and advanced sterilization, infections due to contamination during the storage of implants are still an important problem. In order to overcome these problems, it has become necessary to develop synergistic systems to increase antibacterial performance and prevent biofilm formation. Polymer brush systems are among the strategies that can prevent bacteria and biofilm formation by keeping cell-surface or bacteria-surface interactions to a minimum. In this study, temperature-sensitive poly (di(ethylene glycol)methyl ether methacrylate) (PDEGMA) brush systems were synthesized on implant surfaces using the photoinduced-electron transfer reversible addition dissociation chain transfer polymerization (PET-RAFT) technique. Vancomycin (Van) antibiotic conjugation was achieved by covalently binding PDEGMA brushes to the carboxylic acid functional end groups. At the same time, Van release studies were performed in this system by utilizing the temperature-sensitive feature of PDEGMA. Antibacterial properties were determined after examining the implant-bacteria interaction for both cases. In particular, such synergistic systems will shed important light on implant studies for researchers thanks to their antibacterial capacities.Öğe The value of the naples prognostic score and the systemic ımmune-ınflammation ındex in predicting ıschemia on myocardial perfusion scintigraphy(Multidisciplinary Digital Publishing Institute (MDPI), June 2025) Süygün, Hakan; Yalçınkaya Öner, Damla; Karakulak, Uğur NadirEarly identification of myocardial ischemia is critical for the management of patients with stable angina pectoris (SAP). The Naples Prognostic Score (NPS) and the Systemic Immune-Inflammation (SII) index are emerging biomarkers that may improve risk stratification prior to myocardial perfusion scintigraphy (MPS) Methods: We retrospectively analyzed 615 patients with SAP who underwent MPS to assess the predictive value of the NPS and SII index for myocardial ischemia. Clinical, laboratory, and imaging data were collected. The associations between the NPS, SII, and ischemia detected on MPS were evaluated through univariate and multivariate logistic regression analyses. Results: A higher NPS was strongly associated with the presence of myocardial ischemia (p < 0.001). Male sex, elevated SII, and increased C-reactive protein (CRP) and neutrophile-to-lymphocyte ratio (NLR) values were also significantly related to ischemia. In multivariate analysis, NPS (p < 0.001), SII (p = 0.023), CRP (0.005), and NLR (0.037) values remained independent predictors of ischemia. Albumin levels were significant in univariate analysis but lost independent significance after adjustment. The incorporation of the NPS and SII index provided additional value in identifying patients at high risk of ischemia. Conclusions: The NPS and the SII index are inexpensive, very simple, non-invasive, and valuable markers of myocardial ischemia in patients with SAP. Their integration into clinical practice may enhance risk stratification and optimize diagnostic pathways, minimizing unnecessary invasive procedures.Öğe Effects of blood flow restriction resistance exercise versus traditional resistance exercise in voluntary exhaustion on quadriceps muscle adaptations in untrained young males: a randomized trial(Multidisciplinary Digital Publishing Institute (MDPI), May 2025) Akgül, Mustafa Şakir; Uysal, Hüseyin Şahin; Keskin, Nevin Köremezli; Çetin, Tuğba; Başdemirci, Merve; Soslu, RecepThis study compared the effects of blood flow restriction resistance exercise (BFR-RE) and high-load resistance exercise (HL-RE) in voluntary exhaustion on quadriceps muscle adaptations in untrained young males. Materials and Methods: This study used a randomized controlled design that included 30 untrained young males (age = 21.42 ± 2.51). The BFR-RE group performed leg extension exercises with 60% occlusion pressure and 30% of one maximum repetition in volitional exhaustion. The same exercise was conducted at 70% 1RM in the HL-RE group. Fourteen variables were used to evaluate the intervention efficacy, including muscle thickness, stiffness, strength, cross-sectional area (CSA), and subcutaneous fat thickness. Analyses were reported using frequentist and Bayesian approaches. The Bayes factor (BF10 and BFincl) was interpreted based on negative and positive values. Results: The results revealed that the main effect of time was statistically significant for muscle strength, thickness, CSA, and stiffness (p < 0.05, BFincl > 1) and, in intragroup comparisons, both groups showed improvements in these parameters (p < 0.05, BF10 > 1). A statistically significant decrease in subcutaneous fat thickness was observed in the BFR-RE group (p < 0.05, BF10 > 1), while this change was not observed in the HL-RE group (p > 0.05, BF10 < 1). Similarly, a statistically significant increase in right rectus femoris muscle stiffness was detected in the BFR-RE group (p < 0.05, BF10 > 1) but not in the HL-RE group (p > 0.05, BF10 < 1). Furthermore, time’s main effect was statistically insignificant for thigh circumference (p > 0.05, BFincl < 1). The group × time interaction was statistically significant only for peak power leg flexion left (p < 0.05, BFincl > 1), and a statistically significant difference in favor of the BFR-RE group was observed in the intergroup comparisons (p < 0.05, BF10 > 1). Conclusions: In conclusion, BF-RE exercise with voluntary exhaustion may be as effective as HL-RE for hypertrophic adaptations in untrained young males.Öğe The impact of language variability on artificial intelligence performance in regenerative endodontics(Multidisciplinary Digital Publishing Institute (MDPI), May 2025) Büyüközer Özkan, Hatice; Doğan Çankaya, Tülin; Kölüş, TürkayRegenerative endodontic procedures (REPs) are promising treatments for immature teeth with necrotic pulp. Artificial intelligence (AI) is increasingly used in dentistry; thus, this study evaluates the reliability of AI-generated information on REPs, comparing four AI models against clinical guidelines. Methods: ChatGPT-4o, Claude 3.5 Sonnet, Grok 2, and Gemini 2.0 Advanced were tested with 20 REP-related questions from the ESE/AAE guidelines and expert consensus. Questions were posed in Turkish and English, with or without prompts. Two specialists assessed 640 AI-generated answers via a four-point rubric. Inter-rater reliability and response accuracy were statistically analyzed. Results: Inter-rater reliability was high (0.85–0.97). ChatGPT-4o showed higher accuracy with English prompts (p < 0.05). Claude was more accurate than Grok in the Turkish (nonprompted) and English (prompted) conditions (p < 0.05). No model reached ≥80% accuracy. Claude (English, prompted) scored highest; Grok-Turkish (nonprompted) scored lowest. Conclusions: The performance of AI models varies significantly across languages. English queries yield higher accuracy. While AI shows potential for REPs information, current models lack sufficient accuracy for clinical reliance. Cautious interpretation and validation against guidelines are essential. Further research is needed to enhance AI performance in specialized dental fields.Öğe The influence of various cereal brans, stabilized through hot air, microwave, and autoclave methods, on the physicochemical properties of cookies(John Wiley and Sons Inc, June 2025) Solmaz, Büşra; Levent, Hacer; Şahin, NazlıThis study aimed to evaluate the effects of stabilizing wheat, rye, and oat brans using hot air, microwave, and autoclave methods. The stabilized brans were incorporated into cookies at 20% (w/w) based on wheat flour. The impact of bran type and stabilization method was assessed in terms of proximate composition, color, bioactive components, dietary fiber, mineral content, and texture. The results showed that both bran type and stabilization method significantly influenced the color characteristics of the cookies (p < 0.05). Wheat bran increased ash content, while oat bran enhanced protein, total phenolic content (TPC), and antioxidant activity (AA). Autoclaving yielded the highest TPC and AA, and the lowest phytic acid level. Cookies with wheat and rye bran had higher soluble dietary fiber (SDF) and total dietary fiber (TDF), although TDF decreased in all stabilized samples. Hot air improved insoluble dietary fiber (IDF), while microwave treatment enhanced SDF. The physical dimensions (diameter, thickness, spread ratio) and textural properties (hardness, fracturability) of cookies were only slightly affected. Wheat bran increased calcium, magnesium, and zinc levels by 1.5-, 1.9-, and 1.9-fold, respectively. Microwave and autoclave treatments further elevated potassium, concentrations. These findings suggest that stabilized cereal brans can be effectively utilized to formulate fiber- and mineral-rich cookies with improved antioxidant capacity. Microwave and autoclave treatments, in particular, show promise for developing functional bakery products targeted at health-conscious consumers. The application of these techniques also aligns with sustainable and value-added food production strategies, supporting broader industrial use.Öğe Salivary levels of supar, hıf-1α and tnf-α in different grades of stage ııı periodontitis(BioMed Central Ltd, 2025) Taşdemir, İsmail; Özgören, Özgür; Yılmaz, Huriye Erbak; Kartal, Emine; Altunyaprak, Şeyma; Sağlam, MehmetThe aim of the study is to evaluate saliva levels of Soluble urokinase plasminogen activator receptor (suPAR), Hypoxia-inducible factor-1 alpha (HIF-1α) and tumor necrosis factor-alpha (TNF-α) in stage III grade A, grade B, grade C periodontitis and periodontal health and to understand the roles of these molecules in periodontal inflammation process and also to compare the three biomarkers' discriminative efficacy in periodontal disease. Methods: A total of 80 individuals, 20 with stage III grade A periodontitis (group A), 20 with stage III grade B periodontitis (group B), 20 with stage III grade C periodontitis (group C) and 20 with healthy periodontium (group H) were recruited for this study. Full-mouth clinical periodontal measurements were recorded in periodontal charts. Whole saliva samples were collected to determine the levels of suPAR, HIF-1α and TNF-α in study groups using enzyme-linked immunosorbent assay (ELISA) method. Results: The saliva concentration of suPAR, HIF-1α, and TNF α was significantly higher in group A, group B, and group C compared with group H (p <.05). Additionally, salivary suPAR concentration was significantly higher in group C than in groups A and B (p <.05). Positive statistically significant correlations were observed between three biomarkers and all clinical parameters (p <.05). Conclusions: Increased levels of saliva suPAR, HIF-1α, and TNF α suggest that these molecules may play a role in periodontitis. In addition, the higher salivary suPAR levels in grade C periodontitis compared to other grades suggest that suPAR may be one of the potential molecules that can be used to predict disease progression and periodontal disease classification. Trial registration: Before starting the study, the study plan was uploaded to clinicaltrials.gov.tr and an identification number was obtained (Date: 21.05.2024, İdentification number: NCT06430450).Öğe Trait anxiety, dispositional hope and mental well-being: examining longitudinal mediation(BioMed Central Ltd, 2025) Akat, Muhammedhe associations among trait anxiety, dispositional hope, and mental well-being have been examined in cross-sectional studies. However, no longitudinal research has examined the relationships between these variables, creating a significant gap in the literature. This study collected data at two-time points (T1–T2) at six-month intervals. The study’s participants were 297 adolescents. This study employed a longitudinal design to investigate whether trait anxiety (T2) and dispositional hope (T2) mediate the association between trait anxiety (T1) and mental well-being (T2) in a sample of Turkish adolescents. A cross-lagged panel model was used in this study for a half-longitudinal design to test mediation. The results showed that dispositional hope (T2) had a longitudinal mediating role in the relationship between trait anxiety (T1) and mental well-being (T2). Additionally, it was found that trait anxiety (T2) had a longitudinal mediating role in the relationship between trait anxiety (T1) and mental well-being (T2). Based on the findings of this study, mental health professionals may utilize hope-oriented interventions in the prevention of trait anxiety among adolescents.Öğe Analysis of anthropometric measurements in u-15 female weightlifters using kinect camera and comparison with traditional methods(Springer Science and Business Media Deutschland GmbH, 2025) Işık, Bülent; Erdağı, Kenan; Örücü, Serkan; Osmanoğlu, Usame Ömer; Özbay, ErkanAnthropometric measurements are important in a wide range of areas, from athlete selection to performance analysis and medical exercise applications. With its portable and cost-effective structure, Microsoft Kinect offers significant advantages in measuring human movements and provides valuable data in the fields of sports science and medicine. The aim of this study is to compare certain anthropometric measurements of adolescent female weightlifters in the U-15 age category with Kinect V2 and traditional methods. Twelve athletes who won medals in international weightlifting championships were included in the study. Anthropometric evaluations of each athlete were performed using Kinect V2 and the traditional method. Differences between measurements were analyzed with Bland–Altman plots and Pearson correlation coefficients. Kinect was found to exhibit less variability and higher coherency in measurements of humerus, forearm, trochanter-tibiale laterale, tibial lengths, and shoulder width. It has been observed that the traditional method provides more coherence results in hand length measurements. Kinect was found to exhibit less variability and higher coherency in measurements of forearm, trochanter-tibiale laterale, tibial lengths, and shoulder width, indicating its potential as a reliable tool for these parameters. Notably, Kinect demonstrated high reliability for tibial length (ICC 0.918) and moderate reliability for trochanter-tibiale laterale (ICC 0.737), showing its effectiveness in these measurements. Additionally, Kinect exhibited lower variation and higher coherency in most measurements compared to manual methods, supporting its consistency and repeatability in anthropometric assessments. These results indicate that Kinect may be a suitable tool for some measurements but that traditional methods may be preferable for hand length measurements. These findings suggest that Kinect can be used effectively for certain anthropometric measurements in sports and medical science.Öğe Effect of maternal depression and anxiety scores on the development of three-month-old babies through the assessment of general movements(Elsevier Ireland Ltd, 2025) Başaran, Aynur; Dülger, Özlem; Başaran, MustafaDepression and anxiety symptoms are common during pregnancy, which poses significant risks not only for mothers but also babies. Exposure of the fetus to maternal distress during pregnancy can lead to impairments of the newborn's development that persist throughout their lives. The objective of this study is to investigate whether prenatal exposure to maternal depression and anxiety symptoms has an impact on the neurological status of infants by assessing the quality of general movements at 3 months of age. Methods: In this study, 101 uncomplicated pregnant patients who completed 36 weeks of gestation and their healthy newborns were analyzed. The Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory-Trait (STAI-T) questionnaires were used to assess mothers' distress. 3 months after the birth, general movements (GMs) assessments were conducted using video recordings of their babies. The scores of the questionnaires were compared between the infants grouped as “normal GMs” and “abnormal GMs”. Results: Twenty-six infants exhibited abnormal GMs, while 75 exhibited normal. There was a statistically significant difference in maternal BDI and STAI-T scores between infants exhibiting abnormal and normal GMs. Conclusion: Our study revealed that a mother's higher anxiety and depression scores during the latter stages of pregnancy might negatively affect the early development of the newborn and this can be determined at 3 months of age by evaluating the quality of GMs. This highlights the importance of monitoring the distress experienced by the mother and the quality of GMs exhibited by newborns and taking preventative measures.Öğe 3’utr rna editing driven by adar1 modulates mdm2 expression in breast cancer cells(Springer Nature, 2025) Almeric, Elanur; Karagözoğlu, Deniz; Çiçek, Mustafa; Dioken, Didem Naz; Taç, Hüseyin Avni; Çiçek, EsraEpitranscriptomic changes in the transcripts of cancer related genes could modulate protein levels. RNA editing, particularly A-to-I(G) editing catalyzed by ADAR1, has been implicated in cancer progression. RNA editing events in the 3’ untranslated region (3’UTR) can regulate mRNA stability, localization, and translation, underscoring the importance of exploring their impact in cancer. Here, we performed an in silico analysis to detect breast cancer enriched RNA editing sites using the TCGA breast cancer RNA-seq dataset. Notably, the majority of differential editing events mapped to 3’ untranslated regions (3’UTRs). We confirmed A-to-I(G) editing in the 3’UTRs of MDM2 (Mouse Double Minute 2 homolog), GINS1 (GINS Complex Subunit 1), and F11R (Junctional Adhesion Molecule A) in breast cancer cells. RNA immunoprecipitation with ADAR1 antibody confirmed the interaction between ADAR1 and MDM2, GINS1, and F11R 3’UTRs. ADAR1 knockdown revealed decreased editing levels, establishing ADAR1 as the editing enzyme. A reporter assay for MDM2, an oncogene overexpressed mostly in luminal breast cancers, demonstrated that RNA editing enhances protein expression, in agreement with reduced MDM2 protein levels in ADAR1 knockdown cells. Further exploration into the mechanisms of 3’UTR editing events revealed an interaction between ADAR1 and CSTF2, a core component of the polyadenylation machinery, as identified through biotin-based proximity labeling mass spectroscopy, and co-immunoprecipitation experiments. Furthermore, CSTF2 knockdown reduced both ADAR1 and MDM2 protein levels. Our findings highlight implications for MDM2 regulation by ADAR1-dependent 3’UTR RNA editing and present an interplay between RNA editing on 3’UTRs and the mRNA polyadenylation machinery. These results improve our understanding of ADAR1’s role in cancer-associated 3’ UTR RNA editing and its potential as a therapeutic target.Öğe Evaluation of head posture in patients with temporomandibular joint disorders: a cross-sectional study(Associacao Medica Brasileira, 2025) Özmen, Elif Esra; Ünüvar, Bayram SönmezThis study evaluated head posture in patients with temporomandibular joint disorders and explored the effects of postural changes on clinical parameters. METHODS: In total, 81 individuals diagnosed with temporomandibular joint disorders participated in this cross-sectional prospective study. Demographics, pain status, head posture, and jaw movement data were collected. Head posture was assessed using the Posture Screen Mobile application. RESULTS: Results indicated moderate negative correlations between pain and mouth opening (rho=-0.437, p<0.001) and maximum mouth opening (rho=-0.427, p<0.001). Anterior translation showed weak positive correlations with mouth opening and maximum mouth opening, while right lateral translation exhibited a weak positive correlation with pain (rho=0.264, p=0.017). Posterior angulation showed weak significant correlations with pain, mouth opening, and maximum mouth opening. CONCLUSION: These findings suggest that head posture has a significant influence on temporomandibular joint disorder symptoms. Treatment strategies addressing postural abnormalities may help alleviate symptoms and enhance the quality of life in temporomandibular joint disorder patients.Öğe Machine learning modeling and response surface methodology driven antioxidant and anticancer activities of chitosan nanoparticle-mediated extracts of Bacopa monnieri (vol 310, 143470, 2025)(Elsevier B.V., 2025) Bulut, Şeyma; Aasim, Muhammad; Emsen, Buğrahan; Ali, Seyid Amjad; Aşkın, Hakan; Karataş, MehmetThe authors regret that the affiliations of Bugrahan Emsen and Mehmet Karatas were published wrong in the above-mentioned article. The correct affiliations are: Bugrahan Emsen – Department of Biology, Kamil Ozdag Faculty of Science, Karamanoglu Mehmetbey University, 70200 Karaman, Turkey; Mehmet Karatas – Department of Biotechnology, Faculty of Science, Necmettin Erbakan University, 42090 Konya, Turkey. The authors would like to apologise for any inconvenience caused.Öğe İnsight into the photoluminescence of ba2cd(bo3)2: re3+ (re = dy, tb) phosphors(Springer, 2025) Toreli, S. B; Kafadar, V. E.; Emen, F. M.; Özturk, Esra; Altınkaya, RDy3+ and Tb3+ ions doped Ba2Cd(BO3)2 phosphors with varying concentrations (2, 3, 4, 5, 6 mol%) were produced via the solid-state synthesis method in air. The as-synthesized phosphors were characterized. The photoluminescence (PL) and photoluminescence excitation (PLE) spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Dy3+ ions reveal four distinct emission bands in the blue, yellow, and red regions, with the 575 nm emission band (4F9/2 -> 6H13/2, electric dipole transition) exhibiting a notably higher intensity than the 481 nm band (4F9/2 -> 6H15/2, magnetic dipole transition). The optimal Dy3+ doping concentration was identified as 5 mol%, beyond which concentration quenching effects became apparent. Additionally, excitation and emission spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Tb3+ ions demonstrate efficient energy absorption at approximately 225 nm, with characteristic emission bands observed at 415, 436, 488, 544, 586, and 621 nm, corresponding to the 5D3 -> 7F5, 5D3 -> 7F4, 5D4 -> 7F6, 5D4 -> 7F5, 5D4 -> 7F4, and 5D4 -> 7F3 transitions, respectively. The ideal concentrations for Dy3+ (5 mol%) and Tb3+ (6 mol%) in Ba2Cd(BO3)2 are identified at x = 0.3717, y = 0.4064, and x = 0.2902, y = 0.5344, respectively, as per the Commission Internationale de l'Eclairage (CIE) color spectrum, positioning Dy3+-doped phosphors within the yellow spectrum and Tb3+-doped phosphors within the green spectrum. These phosphors exhibit vibrant yellow and green luminescence, demonstrating their suitability as candidates for applications in these hues. They can be employed when stimulated by near-UV, UV, and blue laser diodes for WLEDs.Öğe Search for fractionally charged particles in proton-proton collisions at (formula presented)(American Physical Society, 2025) Hayrapetyan A.; Tumasyan A.; Adam W.; Andrejkovic J.W.; Bergauer T.; Sağır, SinanA search is presented for fractionally charged particles with charges below (Formula presented), using their small energy loss in the tracking detector as a key variable to observe a signal. The analyzed dataset corresponds to an integrated luminosity of (Formula presented) of proton-proton collisions collected at (Formula presented) in 2016-2018 at the CERN LHC. This is the first search at the LHC for new particles with a charge between (Formula presented) and (Formula presented), including an extension of previous results at a charge of (Formula presented). Masses up to 640 GeV and charges as low as (Formula presented) are excluded at 95% confidence level. These are the most stringent limits to date for the considered Drell-Yan-like production mode. © 2025 CERN, for the CMS Collaboration.Öğe Evaluation of the therapeutic potential of a Schiff Base Compound: Pharmacokinetic profiling, molecular docking for Enoyl-Acyl carrier protein reductase (InhA), antimicrobial, and anticancer properties(Elsevier B.V., 2025) Şahin Doğan, Suzan; Çiçek, Mustafa; Aydın, Duygu; Kocabaş, AytaçThis study investigates the therapeutic potential of a Schiff base compound (phenolphthalein derivate appended 2-furoic hydrazide) using in silico drug similarity predictions, molecular docking, and in vitro antimicrobial and cytotoxicity assays. Despite low solubility (LogS −5.564) and gastrointestinal absorption challenges, the compound demonstrates moderate lipophilicity (LogP 3.459) and strong binding affinity to mycobacterial targets, including enoyl-acyl carrier protein reductase (InhA) in Mycobacterium tuberculosis (−9.11 kcal/mol), suggesting antimicrobial potential. In vitro antimicrobial assays show significant activity against Gram-positive (Bacillus cereus, Bacillus licheniformis) with a minimum inhibitory concentration (MIC) of 0.1 mM. The compound is bactericidal against Gram-positive bacteria and bacteriostatic against Gram-negative bacteria. Cytotoxicity tests on liver cancer (Mahlavu), normal liver (THLE2), and breast cancer (MCF7) cell lines reveal dose-dependent decreases in cell viability, with IC50 values of 8.77 ± 0.39 μM (Mahlavu), 10.78 ± 0.43 μM (THLE2), and 19.25 ± 2.97 μM (MCF7), indicating selective anticancer activity, particularly in liver cells. While the compound shows promising antimicrobial and anticancer effects, concerns about bioavailability, drug-drug interactions, and toxicity require further optimization. Enhancing its pharmacokinetic properties and investigating metal complexes could improve its therapeutic potential for clinical use.Öğe Investigation of psychological resilience and care burden of parents caring for children with special healthcare needs in Turkey: A cross-sectional study(W.B. Saunders, 2025) Ceylan, Ali; Demirdel, ErtuğrulAim: The study was planned to investigate the resilience and care burden of caregiving parents in Turkey. Methods: Demographic and descriptive characteristics were recorded. Psychological resilience was assessed using the Brief Resilience Scale (BRS) and caregiving burden was assessed using the Zarit Caregiving Burden Scale (ZCBS). Independent Sample t-test and ANOVA Mann-Whitney U and Kruskall Wallis tests were used to analyze the data.Multivariate variance analysis was performed with post-hoc tests to determine the differences between the groups. Significance p < 0.05 was accepted. Results: A total of 112 caregivers, 97 of whom were women, with a mean age of 39.84 ± 10.73 years, participated in the study. The mean age of with children with special healthcare needs was 10.83 ± 8.56 years, 61.6 % were male, and 42.9 % had both physical and mental disabilities. In children with special health needs, 41.1 % had mobility limitations, 43.8 % had communication problems, 44.6 % had learning problems and 31.3 % had nutritional problems. The level of mobility limitation, communication, learning and nutrition problems in children with special healthcare needs and the presence of chronic disease or musculoskeletal system problems in caregivers were found to be associated with care burden (p < 0.05). Psychological resilience of caregivers of those with moderate care burden was lower than those with mild care burden (p < 0.05). There was a negative, moderately significant relationship between caregivers' psychological resilience and care burden (r = −0.356; p < 0.001). Conclusion: New strategies should be developed to increase psychological resilience and reduce the burden of care in caregivers of complex children with special healthcare needs. Implications to practice: The lived experience of caregivers who support children with special healthcare needs can be improved with psychological and practical care support from health professionals. © 2025 Elsevier Inc.Öğe Does running performance relate to the market value of elite male soccer players? A case study from the FIFA world cup(Bmc, 2025) Kılcı, Abdullah; Koç, Muhammed Emin; Binokay, Hülya; Erdoğan, Ali; Kamış, Okan; Oliveira, RafaelThe study main aim was to investigate: the relationship between running performances and market values of soccer players playing in the 2022 FIFA World Cup, by playing position and all players; the comparisons by playing position; to analyse the relationship between running metrics and market values of the highest and lowest players ranked players. The relationship between running metrics and market values of 306 soccer players who participated in the tournament and played full time, as well as the 40 players with the highest (n = 20) and lowest (n = 20) market values was analysed. Overall, there was a very weak correlation between market values and total distance (r = 0.149), zone 3 (r = 0.153), zone 4 (r = 0.139), zone 5 (r = 0.160), high-speed runs (r = 0.132), sprints (r = 0.147), and top speed (r = 0.194) for all players (p < 0.05). Defenders showed very weak positive correlation between market values and top speed (r = 0.155, p < 0.05). Midfielders showed weak positive correlations between market values and zone 4 (r = 0.302, p < 0.05) and zone 5 (r = 0.369, p < 0.001), sprints (r = 0.367, p < 0.001), and top speed (r = 0.304, p < 0.05). Forwards showed no correlations (p > 0.05). While there is no significant correlation between running metrics and market value for players with the lowest market value (p > 0.05), there was a moderate negative correlation between total distance (r=-0.577) and zone 2 (r=-0.612) for the 20 players with the highest market value (p < 0.05). Moreover, there was a weak correlation with zone 5 (r = 0.450) and a moderate correlation with the top speed values (r = 0.596) (p < 0.05). Weak correlations between soccer players' running performance and market values suggest that different running thresholds are important metrics, although other factors (e.g., technical skill, age, national and team club) may influence this relationship. In conclusion, since coaches and scouts aim to recruit relatively talented players within the limits of their budgets, selecting athletes with high aerobic and anaerobic performance, particularly those with a strong high-intensity running profile, can contribute to team success and potentially generate high transfer revenues in the future.Öğe İnsight into the photoluminescence of ba2cd(bo3)2: re3+ (re = dy, tb) phosphors(Springer, 2025) Toreli, S. B.; Kafadar, V. E.; Emen, F. M.; Öztürk, Esra; Altınkaya, R.Dy3+ and Tb3+ ions doped Ba2Cd(BO3)2 phosphors with varying concentrations (2, 3, 4, 5, 6 mol%) were produced via the solid-state synthesis method in air. The as-synthesized phosphors were characterized. The photoluminescence (PL) and photoluminescence excitation (PLE) spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Dy3+ ions reveal four distinct emission bands in the blue, yellow, and red regions, with the 575 nm emission band (4F9/2 -> 6H13/2, electric dipole transition) exhibiting a notably higher intensity than the 481 nm band (4F9/2 -> 6H15/2, magnetic dipole transition). The optimal Dy3+ doping concentration was identified as 5 mol%, beyond which concentration quenching effects became apparent. Additionally, excitation and emission spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Tb3+ ions demonstrate efficient energy absorption at approximately 225 nm, with characteristic emission bands observed at 415, 436, 488, 544, 586, and 621 nm, corresponding to the 5D3 -> 7F5, 5D3 -> 7F4, 5D4 -> 7F6, 5D4 -> 7F5, 5D4 -> 7F4, and 5D4 -> 7F3 transitions, respectively. The ideal concentrations for Dy3+ (5 mol%) and Tb3+ (6 mol%) in Ba2Cd(BO3)2 are identified at x = 0.3717, y = 0.4064, and x = 0.2902, y = 0.5344, respectively, as per the Commission Internationale de l'Eclairage (CIE) color spectrum, positioning Dy3+-doped phosphors within the yellow spectrum and Tb3+-doped phosphors within the green spectrum. These phosphors exhibit vibrant yellow and green luminescence, demonstrating their suitability as candidates for applications in these hues. They can be employed when stimulated by near-UV, UV, and blue laser diodes for WLEDs.
