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Öğe İnsight into the photoluminescence of ba2cd(bo3)2: re3+ (re = dy, tb) phosphors(Springer, 2025) Toreli, S. B; Kafadar, V. E.; Emen, F. M.; Özturk, Esra; Altınkaya, RDy3+ and Tb3+ ions doped Ba2Cd(BO3)2 phosphors with varying concentrations (2, 3, 4, 5, 6 mol%) were produced via the solid-state synthesis method in air. The as-synthesized phosphors were characterized. The photoluminescence (PL) and photoluminescence excitation (PLE) spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Dy3+ ions reveal four distinct emission bands in the blue, yellow, and red regions, with the 575 nm emission band (4F9/2 -> 6H13/2, electric dipole transition) exhibiting a notably higher intensity than the 481 nm band (4F9/2 -> 6H15/2, magnetic dipole transition). The optimal Dy3+ doping concentration was identified as 5 mol%, beyond which concentration quenching effects became apparent. Additionally, excitation and emission spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Tb3+ ions demonstrate efficient energy absorption at approximately 225 nm, with characteristic emission bands observed at 415, 436, 488, 544, 586, and 621 nm, corresponding to the 5D3 -> 7F5, 5D3 -> 7F4, 5D4 -> 7F6, 5D4 -> 7F5, 5D4 -> 7F4, and 5D4 -> 7F3 transitions, respectively. The ideal concentrations for Dy3+ (5 mol%) and Tb3+ (6 mol%) in Ba2Cd(BO3)2 are identified at x = 0.3717, y = 0.4064, and x = 0.2902, y = 0.5344, respectively, as per the Commission Internationale de l'Eclairage (CIE) color spectrum, positioning Dy3+-doped phosphors within the yellow spectrum and Tb3+-doped phosphors within the green spectrum. These phosphors exhibit vibrant yellow and green luminescence, demonstrating their suitability as candidates for applications in these hues. They can be employed when stimulated by near-UV, UV, and blue laser diodes for WLEDs.Öğe Search for fractionally charged particles in proton-proton collisions at (formula presented)(American Physical Society, 2025) Hayrapetyan A.; Tumasyan A.; Adam W.; Andrejkovic J.W.; Bergauer T.; Sağır, SinanA search is presented for fractionally charged particles with charges below (Formula presented), using their small energy loss in the tracking detector as a key variable to observe a signal. The analyzed dataset corresponds to an integrated luminosity of (Formula presented) of proton-proton collisions collected at (Formula presented) in 2016-2018 at the CERN LHC. This is the first search at the LHC for new particles with a charge between (Formula presented) and (Formula presented), including an extension of previous results at a charge of (Formula presented). Masses up to 640 GeV and charges as low as (Formula presented) are excluded at 95% confidence level. These are the most stringent limits to date for the considered Drell-Yan-like production mode. © 2025 CERN, for the CMS Collaboration.Öğe Does running performance relate to the market value of elite male soccer players? A case study from the FIFA world cup(Bmc, 2025) Kılcı, Abdullah; Koç, Muhammed Emin; Binokay, Hülya; Erdoğan, Ali; Kamış, Okan; Oliveira, RafaelThe study main aim was to investigate: the relationship between running performances and market values of soccer players playing in the 2022 FIFA World Cup, by playing position and all players; the comparisons by playing position; to analyse the relationship between running metrics and market values of the highest and lowest players ranked players. The relationship between running metrics and market values of 306 soccer players who participated in the tournament and played full time, as well as the 40 players with the highest (n = 20) and lowest (n = 20) market values was analysed. Overall, there was a very weak correlation between market values and total distance (r = 0.149), zone 3 (r = 0.153), zone 4 (r = 0.139), zone 5 (r = 0.160), high-speed runs (r = 0.132), sprints (r = 0.147), and top speed (r = 0.194) for all players (p < 0.05). Defenders showed very weak positive correlation between market values and top speed (r = 0.155, p < 0.05). Midfielders showed weak positive correlations between market values and zone 4 (r = 0.302, p < 0.05) and zone 5 (r = 0.369, p < 0.001), sprints (r = 0.367, p < 0.001), and top speed (r = 0.304, p < 0.05). Forwards showed no correlations (p > 0.05). While there is no significant correlation between running metrics and market value for players with the lowest market value (p > 0.05), there was a moderate negative correlation between total distance (r=-0.577) and zone 2 (r=-0.612) for the 20 players with the highest market value (p < 0.05). Moreover, there was a weak correlation with zone 5 (r = 0.450) and a moderate correlation with the top speed values (r = 0.596) (p < 0.05). Weak correlations between soccer players' running performance and market values suggest that different running thresholds are important metrics, although other factors (e.g., technical skill, age, national and team club) may influence this relationship. In conclusion, since coaches and scouts aim to recruit relatively talented players within the limits of their budgets, selecting athletes with high aerobic and anaerobic performance, particularly those with a strong high-intensity running profile, can contribute to team success and potentially generate high transfer revenues in the future.Öğe İnsight into the photoluminescence of ba2cd(bo3)2: re3+ (re = dy, tb) phosphors(Springer, 2025) Toreli, S. B.; Kafadar, V. E.; Emen, F. M.; Öztürk, Esra; Altınkaya, R.Dy3+ and Tb3+ ions doped Ba2Cd(BO3)2 phosphors with varying concentrations (2, 3, 4, 5, 6 mol%) were produced via the solid-state synthesis method in air. The as-synthesized phosphors were characterized. The photoluminescence (PL) and photoluminescence excitation (PLE) spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Dy3+ ions reveal four distinct emission bands in the blue, yellow, and red regions, with the 575 nm emission band (4F9/2 -> 6H13/2, electric dipole transition) exhibiting a notably higher intensity than the 481 nm band (4F9/2 -> 6H15/2, magnetic dipole transition). The optimal Dy3+ doping concentration was identified as 5 mol%, beyond which concentration quenching effects became apparent. Additionally, excitation and emission spectra of Ba2Cd(BO3)2 phosphors doped with 2, 3, 4, 5, and 6 mol% Tb3+ ions demonstrate efficient energy absorption at approximately 225 nm, with characteristic emission bands observed at 415, 436, 488, 544, 586, and 621 nm, corresponding to the 5D3 -> 7F5, 5D3 -> 7F4, 5D4 -> 7F6, 5D4 -> 7F5, 5D4 -> 7F4, and 5D4 -> 7F3 transitions, respectively. The ideal concentrations for Dy3+ (5 mol%) and Tb3+ (6 mol%) in Ba2Cd(BO3)2 are identified at x = 0.3717, y = 0.4064, and x = 0.2902, y = 0.5344, respectively, as per the Commission Internationale de l'Eclairage (CIE) color spectrum, positioning Dy3+-doped phosphors within the yellow spectrum and Tb3+-doped phosphors within the green spectrum. These phosphors exhibit vibrant yellow and green luminescence, demonstrating their suitability as candidates for applications in these hues. They can be employed when stimulated by near-UV, UV, and blue laser diodes for WLEDs.Öğe Machine learning modeling and response surface methodology driven antioxidant and anticancer activities of chitosan nanoparticle-mediated extracts of bacopa monnieri(Elsevier, 2025) Bulut, Şeyma; Aasim, Muhammad; Emsen, Buğrahan; Ali, Seyid Amjad; Aşkın, Hakan; Karataş, MehmetThis study investigates the potential of chitosan nanoparticles (CNPs) in enhancing the bioavailability and efficacy of Bacopa monnieri extracts, known for their neuroprotective, antioxidant, and anticancer properties. Different concentrations of CNPs were added to the culture medium for in vitro shoot regeneration. Antioxidant activity (DPPH free radical scavenging and H2O2 removal assays) and cytotoxicity assay (LDH release and XTT viability) were performed. The results demonstrated the highest DPPH radical scavenging activity of 95.60 % at 125 mu g/mL CNPs from methanol extract. Whereas, H2O2 scavenging activity increased with higher extract concentrations, and the maximum was recorded from methanol extract when used at 1000 mu g/mL. Cytotoxicity assays revealed a dose-dependent increase in LDH activity and XTT reduction, and water-based extracts demonstrated the strongest cytotoxic effects. IC50 analysis indicated that CNP-enriched methanol and water extracts were significantly more cytotoxic to HeLa cells as compared to ethanol extracts. Response surface regression analysis and ML models confirmed the reliability of the experimental data, with the multilayer perceptron (MLP) model exhibiting the best predictive accuracy, followed by the random forest (RF) model. It can be concluded that CNP enrichment significantly improved the antioxidant and anticancer properties of B. monnieri extracts, highlighting the potential of CNP-based formulations for future studies.Öğe The effects of smoking and airway restriction on subclinical atherosclerosis(Dove Medical Press Ltd, 2025) Yeşildağ, Mihrican; Keskin, Zeynep; Yavşan, Durdu Mehmet; Bekçi, Taha Tahir; Osmanoğlu, Usame ÖmerPurpose: Chronic obstructive pulmonary disease (COPD) is a chronic disease associated with systemic inflammation that may accelerate the atherosclerotic process. Smoking is a common risk factor for COPD and atherosclerosis. The goal of this study was to investigate the effects of COPD and smoking on carotid intima-media thickness (CIMT), in order to emphasise their importance in terms of subclinical atherosclerosis. Materials and Methods: The study involved 208 male patients aged 45-65 years and was designed as a prospective, observational case-control study. Patients were separated into three groups, as follows: Group 1-non-smokers without airway obstruction (control) (n= 70); Group 2-smokers without airway obstruction (n= 70); and Group 3-smokers with airway obstruction(COPD) (n= 68). They were also classified into thickened CIMT (>= 0.8mm) and normal CIMT (<0.8mm) groups. Pulmonary function tests (PFT), carotid Doppler ultrasound, and biochemical and haematological tests were applied to all the participants. Results: CIMT values were markedly increased in the COPD group (1.00 [0.90-1.30] mm), compared to the smoker group without airway obstruction (0.70 [0.58-0.90] mm) and the non-smoker control group (0.60 [0.50-0.70] mm). The factors associated with CIMT were FEV,/FVC ratio (Exp B 0.0952, p=0.003), age (Exp B 1.082, p<0.001), and cigarette pack-years (Exp B 1.030, p=0.020). In feature importance analysis, the most influential factor on CIMT was the FEV,/FVC ratio (0.54) indicating COPD, followed by age (0.33) and cigarette pack-years (0.13). Conclusion: Among the factors influencing CIMT, the impact of a decreased FEV,/FVC ratio was found to be the highest. Therefore, screening with carotid US should be considered for the early detection of subclinical atherosclerosis in patients with COPD.Öğe Bilateral cross hashing image retrieval based on principal component analysis(Springer Heidelberg, 2025) Yılmaz, AhmetImage retrieval (IR) has become a crucial challenge in computer vision with the exponential growth of digital imagery. The existing methods employ a single hash source, which may overlook deep details in the image, and they struggle to handle the complexity and diversity of modern visual data. This study addresses this limitation by proposing a novel deep hashing-based IR method named bilateral cross hashing based on principal component analysis (BCHP). Bilateral cross hashing based on principal component analysis-image retrieval (BCHP-IR) employs the feature extraction capabilities of residual network-50 (ResNet-50) and the dimensionality reduction and information preservation properties of principal component analysis (PCA). The method extracts high-level features from query images using ResNet-50 and then compresses both features and class labels using PCA. The compressed data undergoes quantization to generate binary codes. These "bilateral" hash codes are combined to capture deep features and compared with image codes in the database. The BCHP-IR's effectiveness is demonstrated through extensive comparative analysis against reported methods, achieving superior performance metrics. On the MS-COCO dataset, BCHP-IR achieves mAP scores that are higher than the average of other benchmark algorithms by 6.3, 6.4, 6.2 and 5.0 at hash lengths of 16, 32, 48 and 64, respectively. These enhancements at those hash lengths are 4.6, 4.7, 4.8 and 4.3 for the NUS-WIDE dataset and 3.9, 2.9, 2.5 and 2.1 for the ImageNet dataset. Therefore, the proposed BCHP-IR method harnesses the power of ResNet-50 and PCA and offers a promising solution for efficient and effective image retrieval.Öğe Cardiovascular disease markers in schizophrenia during negative symptoms and remission periods(Mdpi, 2025) İmre, Okan; Imre, Gurkan; Muştu, Mehmet; Acat, Ömer; Kocabaş, RahimObjectives: This study aims to investigate cardiovascular disease markers in patients with schizophrenia and to contribute to the early indication of asymptomatic cardiovascular diseases in these patients. In our study, there are three groups: schizophrenia with negative symptoms (SCH-N), schizophrenia in remission (SCH-R), and a healthy control group (HC). In these groups, there were compared parameters such as lipid panel, Atherogenic Index (AIP), Triglyceride-glucose (TyG) index, Castelli Risk Index-1 (CRI-I), Castelli Risk Index-2 (CRI-II), and Atherogenic Coefficient (AC), which are associated with the risk of cardiovascular disease. Methods: The participants of the study were from the HC group and schizophrenia patients aged between 18 and 65 who were followed up at the Psychiatry Clinic of Karaman Hospital. This cross-sectional case-control study consists of the SCH-N (n:20), the SCH-R (n:23), and the HC (n:21) groups. Those with cardiovascular, endocrine, and inflammatory diseases, those with alcohol and substance addiction, those using drugs other than psychiatric drugs, and those lacking informed consent were excluded from the study. Patients in active psychotic episodes were also excluded from the study due to communication difficulties. All data were analyzed using SPSS 25.0 package program in a computer environment. The conformity of continuous data to normal distribution was evaluated with normality test value, q-q plot, skewness, and kurtosis. For significant results in the ANOVA test, pairwise comparisons were conducted using the post hoc Bonferroni correction when variances were homogeneously distributed. Similarly, for significant results in the Kruskal-Wallis Test, pairwise comparisons were performed using the Dunn-Bonferroni test. In this study, values less than p < 0.05 were considered statistically significant. Results: When all groups were compared, the increase in the TGs, TyG index, AIP, CRI-I, CRI-II, and AC values in the SCH-R group compared to the HC group was found to be statistically significant (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.015, p < 0.001; sequentially). Conclusions: This study revealed that cardiovascular risk markers in schizophrenia patients showed significant differences. In particular, the elevation in parameters such as TGs, TyG index, AIP, CRI-I, CRI-II, and AC indicates that schizophrenia patients have an increased risk for cardiovascular diseases. Therefore, it is recommended that schizophrenia patients be closely monitored for cardiovascular risk factors and to intervene early.Öğe Kinect-based anthropometric measurements: a comparative analysis of traditional methods in youth female weightlifters(Bmc, 2025) Örücü, Serkan; Işık, Bülent; Erdağı, Kenan; Osmanoğlu, Usame Ömer; Özbay, ErkanBackgroundThe importance of anthropometric measurements for monitoring the physical development of athletes and optimizing training programs is well known. Considering the limitations of traditional methods in terms of accuracy and consistency, the aim of this study is to investigate the potential of Kinect V2 as an alternative.MethodsThis study wasperformed on 12 youth female weightlifters who won medals in the Youth European Weightlifting Championship. Humerus length, forearm length, hand length, trochanter-tibiale laterale length, tibial length and shoulder width measurements were performed with both Kinect V2 and manual methods. Statistical differences between groups were evaluated using the Mann-Whitney U test. The consistencies of the measurement methods were analyzed with Bland-Altman plots, correlations were determined with Pearson correlation coefficients, and reliability were evaluated with Intraclass Correlation Coefficient (ICC) values.ResultsKinect V2 provided accuracy and consistency comparable to manual methods in measurements of humerus (ICC = 0.532), forearm (ICC = 0.600), and hand length (ICC = 0.760). While medium-level concordance was observed in trochanter-tibiale lateral length measurements (ICC = 0.749), high-level concordance and reliability were found in tibial length (ICC = 0.914) and shoulder width (ICC = 0.869) measurements.ConclusionsThere were significant differences between the results of humerus length, forearm length and trochanter-tibiale laterale length obtained with both measurement methods. Therefore, measurements of these parameters require significant care. Findings of this study suggest that Kinect V2 can be a reliable tool for rapid and practical anthropometric assessments in sports settings, but highlight the importance of careful calibration and adjustments for specific measurements. Future studies should examine the use of this device more comprehensively across different sports and populations.Öğe Childhood psychological maltreatment, psychological flexibility, family conflict, and subjective happiness in university students: a serial mediation model(Springer, 2025) Akat, Muhammed; Okur, Sinan; Akbulut, Ömer Faruk; Satıcı Seydi Ahmet; Hamarta, ErdalChildhood psychological maltreatment has psychological, behavioral, and emotional repercussions on individuals in adulthood. These reflections play a role in both the internal distress of individuals and the deterioration of their interpersonal relationships. The aim of this study was to examine the serial mediating role of psychological flexibility and family conflict in the relationship between childhood psychological maltreatment and subjective happiness. The study was conducted with 493 university students (61.7% female, 38.3% male), with ages ranging from 18 to 53 years (M-age = 24.02, SD = 6.342). The data of this research was analyzed using structural equation modeling. The findings of the study indicate that psychological flexibility and family conflict have a serial mediating role in the relationship between childhood psychological maltreatment and subjective happiness. The results demonstrated that to improve the subjective happiness of people who have been psychologically abused as children, it is necessary to make them more psychologically flexible and teach them how to deal with family conflict. Overall, these findings emphasize the importance of fostering psychological flexibility and conflict resolution skills as key intervention targets to mitigate the long-term negative effects of childhood psychological maltreatment on subjective happiness. The findings of the study were discussed and interpreted in detail in the light of the relevant literature.Öğe Quality changes in chicken meat marinated with antioxidant-rich fruit and vegetable juices(Wiley, 2025) Çelik, İlkay; Alagöz, Eda; Şen Arslan, Hülya; Sarıçoban, CemalettinThis study investigated the effects of marination with antioxidant-rich fruit juices-pomegranate, black carrot, and red beet-on the textural, physicochemical, technological, and sensory properties of chicken breast meat. Key parameters, including color, pH, water-holding capacity (WHC), marinade absorption, cooking loss (CL), textural properties, TBARS (thiobarbituric acid reactive substances), and sensory attributes, were evaluated. Among the tested juices, pomegranate had the highest acidity. Black carrot contained the highest total phenolic content (TPC) but showed the lowest ABTS and DPPH radical scavenging activity (p < 0.05). Marination resulted in a reduction in pH, with the lowest values observed in pomegranate-marinated samples. Although marination influenced WHC, the changes were not statistically significant (p > 0.05). CL values were significantly reduced in marinated samples (p < 0.05). Marination also affected color, with red beet increasing the b* value and black carrot decreasing it (p < 0.05). Textural properties, such as hardness, significantly increased with pomegranate and red beet juices (p < 0.05), while other textural attributes remained unaffected (p > 0.05). Sensory evaluation revealed no significant differences in flavor and texture, although color was notably influenced by the marination process (p < 0.05). Control and RB gave the highest values in terms of general acceptability. These findings suggest that marination with pomegranate, black carrot, and red beet juices may contribute to improving antioxidative properties and improve the textural quality of chicken breast meat.Öğe Effects of ıntermittent versus continuous small-sided games on athletic performance in male youth soccer players: a pilot study(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Pancar, Zarife; Akay, Mehmet Kaan; İlhan, Muhammet Taha; Karaday, Emre; Karaca, Burak; Ulema, Mustafa Sencer; Taşdoğan, Ali Muhittin; Makaracı, Yücel; González-Fernández, Francisco TomásAdjusting the design of small-sided games and selecting the appropriate format can significantly enhance training outcomes and player development in soccer. The aim of the study was to compare the effects of intermittent small-sided games (ISSG) and continuous small-sided games (CSSG) on athletic performance metrics in male soccer players. This pilot study was conducted using a parallel group pre-test and post-test design, with 16 male youth soccer players randomly assigned to two groups: the ISSG group (n = 8, Mean age = 16.50 ± 0.53 years) and the CSSG group (n = 8, Mean age = 16.63 ± 0.52 years), ensuring a balance in pre-test performance and playing positions. The ISSG protocol began with 4 min sets in week one, progressively increasing to 7 min by week four, with 2 min rest intervals. The CSSG protocol involved continuous play, starting at 16 min and progressing to 28 min over the same period. Players underwent pre- and post-tests, with a 4-week training period. Performance metrics assessed included body composition, a 30 m sprint test, agility, horizontal jump, aerobic and anaerobic capacity, and static balance. Training intensity was monitored using the CR-10 Borg Rating of Perceived Exertion scale throughout the training period. Both groups exhibited improvements in horizontal jump, agility, aerobic and anaerobic power, and static balance, with no significant between-group differences. Sprint performance did not significantly improve in either group. The CSSG group reported higher RPE values and experienced a reduction in body mass index. Our findings demonstrate that both ISSG and CSSG resulted in similar improvements in athletic performance metrics in male youth soccer players. Coaches and practitioners can choose the most appropriate training method based on specific objectives, session duration, and player fatigue levels, thereby optimizing training outcomes. © 2025 by the authors.Öğe Effects of a nurse-led play-based internet addiction prevention program in early adolescents: a randomized controlled study(W.B. Saunders, 2025) Yumru Menteş, Hatice; Koç, ŞerifeObjective: This study aimed to investigate the effectiveness of a play-based program on internet addiction severity, daily internet usage, and game-playing duration among early adolescents. Methods: The study employed a pretest-posttest randomized controlled design. Data were collected using the Adolescent Information Form, Internet Addiction Test, and Follow-up Form. The intervention group received a nurse-led play-based program, while the control group did not receive any intervention. Results: Before the program, the IAT scores, daily internet usage, and daily digital game playing time of the groups were similar. After the program, early adolescents' IAT scores, daily internet use, and daily digital game playing time were found to be significantly lower than the pre-program and control groups. Conclusion: A nurse-led play-based program can be used for school-based prevention of internet addiction. However, further studies are needed to evaluate the long-term effects of these interventions on early adolescents at different stages. © 2025 Elsevier Inc.Öğe 3d modelling and x-ray depth analysis map of the pulp with computer software via digital periapical radiography and cone beam computed tomography(2025) Felek, Turgut; Şatır, Samed; Özel, Şelale; Çelik, H. KürşatObjective: Periapical radiographs (PAR) offer information about the pulp and periodontal health of teeth. However, intraoral radiographs are insufficient for diagnosing buccolingual anomalies and variations such as bifid canals due to their two-dimensional nature. Cone beam computed tomography (CBCT) is the gold standard for 3D imaging in the clinic but requires additional radiation. The aim of this study was to create a software (XPAR) which obtains x-ray depth analysis and 3D modelling of the pulps of single-rooted teeth by converting the grey values in the original radiographs into numerical data. Materials and methods: Two single-rooted teeth were included in the experimental part of the study. Chicken fibula bone was preferred for alveolar bone simulation because it could simulate cortical and trabecular structures due to similarity. A total of four images (60kVp & 70kVp; single alveolar bone & double alveolar bone) were obtained. The aim of this experimental part is to test the repeatability and realism of the algorithm to be created for pulp modelling. Retrospectively, 31 single-rooted teeth with both periapical radiography and cone-beam computed tomography imaging were included in the retrospective part of the study. According to XPAR, depth increase areas were interpreted as root resorption and accessory canal. Depth decrease areas were evaluated as the transformation of the pulp from an elliptical to an oval form, pulp stone, bifid canal formation and the presence of thick alveolar bone. The diagnostic accuracy of XPAR application on pathological and morphological changes was evaluated by comparing the obtained results with CBCT. Results: 80% of the analyses diagnosed as bifurcation by XPAR application were supported by CBCT. This rate decreased to 27% in the diagnosis of transitions from elliptical to oval form. A total of 5 and 19 linear formations observed in the form of depth decrease and increase, respectively, were accepted as image errors in XPAR. Conclusion: Buccolingual bifid canal formations and pulp obliterations can be diagnosed with a rate of nearly 50% with the depth decrease finding obtained in XPAR application. Imaging errors caused by deformed detectors are typically observed as linear formations. © The Author(s) 2025.Öğe Chronic lymphocytic leukemia: investigation of survival and prognostic factors with drug-related remission(Dıagnostics, 2025) Pektaş, Gökhan; Gönül, Ercan; Öncü, Şeyma; Kızılkaya, Merve Becit; Sadi, Goekhan; Pektaş, Mehmet BilgehanBackground/Objectives: Understanding the pathogenesis of chronic lymphocytic leukemia (CLL) has led to the development of new prognostic and diagnostic tools, and efforts are underway to extend survival with new prognostic markers and treatment agents. This study aims to evaluate the factors affecting the prognosis and survival of patients with CLL via a retrospective study. Methods: Accordingly, the demographic features of, clinical and laboratory findings for, and hematological parameters and treatment responses of 178 CLL patients who were followed between 1 January 2015 and 31 December 2024 were analyzed before and after treatment protocols were carried out. Results: During the follow-up period, 40.8% of the patients received medical therapy, with 42.5% achieving complete remission, 49.3% experiencing partial remission, and 8.2% demonstrating no response to the treatments. The results demonstrated that an advanced Binet stage, the presence of splenomegaly, a positive direct Coombs test, the presence of a 17p deletion, thrombocytopenia, and elevated creatinine, leukocyte, and lymphocyte counts were associated with increased mortality. Elevated Binet and Rai stages, the existence of 17p deletion, and reduced hemoglobin levels were identified as statistically significant factors. Conclusions: Given the unfavorable prognosis of CLL patients exhibiting a positive direct Coombs test and compromised renal function, further investigations are required to validate the necessity of more rigorous monitoring and, possibly, early intervention. These findings underscore the importance of identifying high-risk factors in CLL to optimize patient management and improve long-term outcomes.Öğe Sensory properties, textural analysis, and some physical analysis of enriched extruded products produced from different grain products(Dordrecht, 2025) Hayriye Genç; Nizam Mustafa NizamlıoğluA functional product has been produced from a mixture of whole wheat flour and corn semolina, which can be consumed as a healthy snack compared to oily and additive-laden chip products. Extruded products were obtained at various output die temperatures (130, 150, and 170 °C) in a twin-screw extruder from mixtures prepared with different raw material humidity (12, 14, and 16%) from the mixtures of whole wheat flour, corn semolina, and D-glucose. The water binding capacity increased with increasing raw material humidity and output die temperature. Expansion index value was founded corn semolina had the highest value (3.11 ± 0.22), whereas whole wheat flour with D-glucose added had the lowest value (2.10 ± 0.34). Through sensory investigation, the most popular product groupings were determined to be whole wheat flour and corn semolina-extruded products. It is expected that this study will be able to produce extruded products from whole wheat flour and corn semolina and will set an example for the development of new functional products.Öğe Midazolam premedication facilitates mask ventilation in children during propofol induction of anesthesia: a randomized clinical trial(London, 2025) Rafet Yarımoğlu; Betül Başaran; Tayfun Et; Ayşegül Bilge; Muhammet KorkusuzPurpose Mask ventilation is the most widely used method to provide ventilation during anesthesia induction. Appropriate head and neck positions, exaggerated jaw lifts, two-hand and two-person ventilation, and the use of oral or nasal airways can facilitate mask ventilation. Neuromuscular blockers and premedication drugs such as midazolam and dexmedetomidine have also been proposed to facilitate mask ventilation. The hypothesis of this study was that midazolam premedication would facilitate mask ventilation in children. Methods Children aged 2–10 years were randomized into two groups. The midazolam group (Group M) received an intravenous dose of midazolam premedication (0.1 mg/kg, maximum dose 3 mg), and the control group received an intravenous dose of saline of the same volume (Group C). The primary outcome of the study was to examine the effect of midazolam premedication on mask ventilation in children, using the Han mask grading scale. Results The data of 120 children were analyzed (n=60 in Group M, n=60 in Group C). According to the Han mask grading scale, the scores of the patients in the midazolam group were significantly lower than those of the control group. The distribution of Han scores was significantly different between the groups (p<0.001). In the midazolam group, 93.3% of the children had a Han score of 1 and 6.7% had 2, and in the control group, 60% had a score of 1, and 40% had 2. In the subgroup analysis of overweight children, a Han score of 1 was determined in 91.7% of the midazolam group and 61.1% of the control group (p=0.03). Conclusion In conclusion, the results of this clinical research demonstrated that midazolam premedication improves mask ventilation in children during general anesthesia induction. The findings also showed that the effect of midazolam in facilitating mask ventilation was similar in overweight children. Clinical trial registration The study was registered in clinicaltrials.gov (trial ID: NCT05368441 on 10/05/2022).Öğe A case-control study on sh2b1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway(London, 2025) Serkan Küççüktürk; Şebnem Yosunkaya; Mehmet Ali Karaselek; Şennur Demirel; Hasibe VuralBackground: Obstructive sleep apnea (OSA) is a common sleep disorder, frequently observed in obese individuals, with shared mechanisms involving leptin and its receptor, which regulate appetite and energy expenditure. SH2B1 is a key enhancer of signaling in the leptin receptor pathway. This study aimed to investigate the association between SH2B1 variants and OSA. Research design and methods: This case-control study included 160 male patients with OSA and 76 healthy controls, stratified into subgroups based on BMI (≤25 kg/m2 and ≥ 30 kg/m2). Polysomnography and anthropometric measurements were performed, and genotyping of three SH2B1 variants (rs7498665, rs4788102, and rs7359397) was conducted. Results: Mutant genotypes of all three SH2B1 variants were significantly associated with higher BMI. Additionally, normal genotypes of rs4788102 and rs7359397 were associated with higher apnea-hypopnea index (AHI) values, indicating a potential risk for OSA. Conclusion: The findings suggest that while SH2B1 variants are strongly associated with BMI, specific normal genotypes may independently contribute to OSA risk by increasing AHI values.Öğe Assessing spatiotemporal characteristics of meteorological droughts in the Marmara Basin using HadGEM2-ES global climate model data(Springer, 2025) Duvan, Akın; Aktürk, Gaye; Yıldız, OsmanIn this study, spatial and temporal characteristics of meteorological droughts in the Marmara Basin, which is located in the semi-arid climate region with the highest population density in Turkey, were determined using HadGEM2-ES global climate model data. Here, precipitation projection data using both RCP 4.5 and RCP 8.5 scenarios were employed. The Standardized Precipitation Index (SPI) was employed to calculate drought intensities, and areal distributions of drought were determined using the inverse distance weighting (IDW) interpolation method. Drought intensity-area-frequency (DIAF) curves for the basin were created by converting point drought intensity data into areal drought data. The DIAF curves provided analysis of the temporal and spatial characteristics of droughts in the basin and revealed that drought intensities are projected to be higher under the RCP 8.5 scenario.Öğe Characterization of silver nanoparticles synthesized using hypericum perforatum L. and their effects on staphylococcus aureus(Wiley, 2025) Şaşmaz, Canan Sevinç; Erci, Fatih; Torlak, Emrah; Yöntem, MustafaThis study investigates the synthesis of silver nanoparticles (AgNPs) using Hypericum perforatum L. and evaluates their antibacterial and antibiofilm activities against Staphylococcus aureus. The synthesized AgNPs were characterized by UV-Vis spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). UV-Vis spectroscopy showed a maximum absorption peak at 448 nm, which indicates that nanoparticles have been formed successfully. TEM analysis showed that the AgNPs were spherical, with an average size of 35 ± 2.7 nm. FTIR confirmed the presence of functional groups on the surface of AgNP that may be contributing to its biological activity. The AgNPs exhibited significant antibacterial activity, with a minimum inhibitory concentration (MIC) of 75 μg/mL and an inhibition zone of 13 ± 0.13 mm at this concentration. They were also highly effective in inhibiting biofilm formation even at a concentration of 25 μg/mL, reducing biofilm formation by 47.25% ± 3.51%. At increased concentrations, nanoparticles have been shown to compromise bacterial membranes, leading to significant membrane disruption. This disruption subsequently results in a reduction of cellular respiration, with observed decreases of approximately twofold when compared to controls. Additionally, nanoparticles facilitate the production of superoxide anions, which can rise by about threefold, consequently enhancing the overall effectiveness of bacterial inactivation. Field emission scanning electron microscopy (FE-SEM) revealed structural damage to bacterial cells treated with AgNPs, supporting their antimicrobial effects. These findings suggest that AgNPs synthesized from H. perforatum could serve as effective antimicrobial agents against S. aureus. Their ability to disrupt bacterial cell membranes, inhibit respiration, and induce oxidative stress makes them promising candidates for antimicrobial and antibiofilm applications, particularly given the increasing concern over bacterial resistance to conventional antibiotics.
