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Öğe Relationship between epicardial adipose tissue thickness and sedentary time, physical activity level, and physical performance in patients with hypertension(SpringerNature, 2025) Süygün, Emine Tunç; Yağlı, Naciye Vardar; Süygün, HakanEpicardial adipose tissue is associated with the development of cardiovascular disease and its increase is positively correlated with blood pressure elevation in hypertensive individuals. In the literature, being physically active has been shown to be effective in the treatment of hypertension and reduction of epicardial adipose tissue thickness. The aim of this study was to evaluate the relationship between epicardial adipose tissue thickness and sedentary time, physical activity level and physical performance in patients with hypertension. The physical and demographic characteristics of the 40 patients with hypertension were collected with sociodemographic form. Waist/hip circumference was measured with tape measure and epicardial adipose tissue thickness with echocardiography device. Physical activity levels and sedentary time were recorded via IPAQ-7. Physical performance was determined using the 30-s sit-and-stand test. There was a moderate negative correlation between epicardial adipose tissue thickness and IPAQ-7 score (rho: -0.568 p < 0.001) and a high negative correlation between epicardial adipose tissue thickness and sit-and-stand test score (rho: -0.794 p < 0.001). There was no relationship between epicardial adipose tissue thickness and daily sitting time, BMI, or hip circumference. There was moderate positive correlation between epicardial adipose tissue thickness and age (rho: 0.504 p: 0.001) and low positive correlation between waist circumference (rho: 0.322 p < 0.05).This study demonstrated that the epicardial adipose tissue thickness was negatively associated with activity and performance in hypertensive patients, but not with daily sitting time. These results underscore the importance of physical activity in the management and prevention of chronic diseases.Öğe Predictive factors of cardiac function recovery and mortality in patients with reduced ejection fraction undergoing transcatheter aortic valve implantation(MDPI, 2025) Güney, Murat Can; Süygün, Hakan; Polat, Melike; Ayhan, Hüseyin; Keleş, Telat; Ertop, Zeynep Şeyma TurinayBackground and Objectives: Patients with reduced left ventricular ejection fraction (LVEF) are reported to have unfavorable outcomes following transcatheter aortic valve implantation (TAVI). This study aims to evaluate outcomes and identify predictive factors for LVEF recovery following TAVI in patients with reduced LVEF. Materials and Methods: This retrospective study analyzed 114 patients with symptomatic severe aortic stenosis (AS) with LVEF < 40% who underwent TAVI between 2011 and 2023 at two centers. Echocardiographic parameters, including LVEF, ventricular dimensions, and relative wall thickness (RWT), were assessed at baseline and during follow-up. The outcomes and predictors of substantial LVEF improvement and mortality were analyzed using univariate and multivariate logistic regression methods. Results: Anemia (OR = 4.345, 95% CI: 1.208-15.626, p = 0.024), RWT (OR = 1.224, 95% CI: 1.064-1.407, p = 0.005), and early post-procedural changes in left ventricular end-systolic dimension (LVESD) (OR = 1.297, 95% CI: 1.037-1.622, p = 0.023) and left ventricular end-diastolic dimension (LVEDD) (OR = 1.346, 95% CI: 1.034-1.753, p = 0.027) at one-month follow-up were identified as significant factors associated with LVEF recovery at one year. Regarding factors related to mortality, higher baseline AVMG levels were associated with a lower probability of death after one year (OR = 0.926, 95% CI: 0.875-0.979, p = 0.007). Conversely, a more limited increase in LVEF from baseline to the final follow-up was linked to poor prognosis and higher mortality at one year (95% CI: 1.045-1.594, p = 0.018). Conclusions: This study demonstrated that TAVI in patients with AS and reduced LVEF can be performed with high procedural success, low mortality, and significant improvement in cardiac function during follow-up. Additionally, anemia, baseline RWT, and early post-procedural changes in LVESD and LVEDD were identified as factors associated with LVEF recovery. Baseline AVMG and changes in LVEF at the final follow-up were found to be significant predictors of total mortality.Öğe A comparative evaluation of radiographic and computed tomography results in patients with lower respiratory tract infections with positive and negative sputum cultures: a retrospective observational study(Wiley, 2025) Kaya, Murat; İncekara, Yaşar; Aslan, Selda; Kaya, Fatima Merve; Şahin, AhmetBackground and aim There is limited data on the correlation between findings of lower respiratory tract infections detected by chest computed tomography but not by chest radiography and sputum culture results. The aim of this study is to evaluate the relationship among sputum culture results, chest radiographic findings and computed tomography outcomes in patients diagnosed with lower respiratory tract infections. Materials and Methods Between January 2021 and September 2023, the clinical and radiological findings of patients diagnosed with lower respiratory tract infections, both those with and without positive sputum cultures, were retrospectively evaluated. Results In the studied cohort, 65.4% (n = 172) of the patients were male and 34.6% (n = 91) were female, with an overall mean age of 67.18 +/- 13.77 years. On chest computed tomography, consolidation was observed in 39.53% (n = 34) of patients with positive sputum cultures, compared to 23.72% (n = 42) of patients with negative cultures (p = 0,005). Furthermore, necrotising pneumonia findings were noted in 5.81% (n = 5) of culture-positive patients and 1.13% (n = 2) of culture-negative patients (p = 0.034). Infiltrative changes were detected in 81.4% (n = 70) of patients with positive cultures and 66.6% (n = 118) of patients with negative cultures on chest radiography (chi(2) = 20,492; p < 0.001). Conclusion The identification of findings on chest radiography is notably challenging in patients diagnosed with lower respiratory tract infections due to the presence of non-consolidative infiltrates and their respective anatomical locations. Moreover, the probability of detecting radiological findings on chest radiographs is enhanced in patients exhibiting positive sputum cultures.Öğe The relationship between fibromyalgianess and clinical features, disease activity in patients with systemic lupus erythematosus(Wiley, 2025) Varman, Büşra; Parlak, Selman; Ecesoy, HilalIntroduction: Fibromyalgia (FM) is a chronic syndrome characterised by widespread pain, fatigue, and symptoms such as sleep disturbances, cognitive impairment, and mood disorders. FM prevalence is notably higher among systemic lupus erythematosus (SLE) patients compared with the general population, often leading to diagnostic challenges. Misinterpreting FM as SLE activity can result in overtreatment. This study aimed to evaluate fibromyalgianess and its relationship with the clinical and immunological characteristics of SLE patients using comprehensive scoring methods for better diagnostic accuracy. Materials and Methods: This cross-sectional study included 50 SLE patients meeting the 2019 EULAR/ACR classification criteria. Patients with coexisting autoimmune diseases or severe systemic conditions were excluded. Clinical data, SLEDAI scores, and fibromyalgianess severity were assessed using the Polysymptomatic Distress Scale (PSDS). Patients were categorised into groups based on fibromyalgia diagnostic criteria: widespread pain and SLE-FM. Statistical analysis was performed using SPSS, with p < 0.05 considered significant. Results: Among 50 patients (45 female, 5 male; mean age 42.04 +/- 12.5), 24% had fibromyalgianess, and 18% experienced widespread pain. Female patients exhibited significantly higher PSDS scores (p < 0.05). While NSAID use was associated with increased PSDS scores (p < 0.001), no significant relationship was found between fibromyalgianess and SLEDAI scores or organ involvement. Conclusion: Fibromyalgianess in SLE patients primarily reflects heightened pain sensitivity and symptom severity rather than disease activity. Incorporating fibromyalgianess assessment into routine SLE management may prevent diagnostic and therapeutic pitfalls and improve treatment outcomes. Multidisciplinary approaches, including pharmacological and non-pharmacological strategies, are essential for effective care.Öğe Periaortic fat thickness and cardiovascular risk factors in children with congenital adrenal hyperplasia(Cambridge Univ Press, 2025) Akyürek, Nesibe; Eklioğlu, Beray Selver; Atabek, Mehmet Emre; Alp, Hayrullah; Gün, Halil İbrahimObjective: Children with congenital adrenal hyperplasia are considered to be at an elevated risk for cardiovascular morbidity and mortality. The objective of this study was to evaluate the association between periaortic fat thickness and the cardiometabolic profile in children diagnosed with congenital adrenal hyperplasia.Method: A total of 20 children and adolescents with congenital adrenal hyperplasia and 20 healthy control subjects were enrolled in the study. We investigated metabolic and anthropometric parameters, comparing these values to those of the control group. Periaortic fat thickness was assessed using an echocardiographic method that has not previously been applied to paediatric patients with congenital adrenal hyperplasia.Results: The subjects in the congenital adrenal hyperplasia group were significantly shorter than the control subjects (p = 0.021) and exhibited a higher body mass index (p = 0.044) and diastolic blood pressure (p = 0.046). No significant differences were observed between the congenital adrenal hyperplasia group and control subjects concerning age, weight, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels. Additionally, dyslipidemia was identified in 5% (N = 1) of the congenital adrenal hyperplasia group. The mean fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and fasting glucose-to-fasting insulin ratio were similar between the congenital adrenal hyperplasia group and the control subjects. However, 15% (n = 3) of the congenital adrenal hyperplasia group had insulin resistance. Two children with congenital adrenal hyperplasia (10%) were diagnosed with hypertension. Periaortic fat thickness was significantly greater in the congenital adrenal hyperplasia group compared to the control group (p = 0.000), with measurements of 0.2039 +/- 0.045 mm in the congenital adrenal hyperplasia group and 0.1304 +/- 0.022 mm in the control group. In children with congenital adrenal hyperplasia, periaortic fat thickness exhibited a negative correlation with high-density lipoprotein cholesterol (r = -0.549, p = 0.034) and a positive correlation with the dose of hydrocortisone (r = 0.688, p = 0.001).Results: The subjects in the congenital adrenal hyperplasia group were significantly shorter than the control subjects (p = 0.021) and exhibited a higher body mass index (p = 0.044) and diastolic blood pressure (p = 0.046). No significant differences were observed between the congenital adrenal hyperplasia group and control subjects concerning age, weight, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels. Additionally, dyslipidemia was identified in 5% (N = 1) of the congenital adrenal hyperplasia group. The mean fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and fasting glucose-to-fasting insulin ratio were similar between the congenital adrenal hyperplasia group and the control subjects. However, 15% (n = 3) of the congenital adrenal hyperplasia group had insulin resistance. Two children with congenital adrenal hyperplasia (10%) were diagnosed with hypertension. Periaortic fat thickness was significantly greater in the congenital adrenal hyperplasia group compared to the control group (p = 0.000), with measurements of 0.2039 +/- 0.045 mm in the congenital adrenal hyperplasia group and 0.1304 +/- 0.022 mm in the control group. In children with congenital adrenal hyperplasia, periaortic fat thickness exhibited a negative correlation with high-density lipoprotein cholesterol (r = -0.549, p = 0.034) and a positive correlation with the dose of hydrocortisone (r = 0.688, p = 0.001).Conclusion: Our results provide further evidence of subclinical cardiovascular disease in children with congenital adrenal hyperplasia. It is crucial to regularly assess cardiometabolic risk in children with congenital adrenal hyperplasia. The measurement of periaortic fat thickness in this population may serve as a valuable tool for identifying individuals at high risk for developing early atherosclerosis.Öğe Does pregabalin affect renal functions and plasma electrolytes?(Wiley, 2023) Günay, Ahmet Can; Görmüş, Z. Işık Solak; Günay, Merve Akgül; Koca, Raviye Özen; Özdengül, FaikAim: It is known that the half-life of pregabalin increases with age. This may be related to the decline in kidney function with age. In this study, it was aimed to investigate the neurotoxicity and renal toxicity that pregabalin may cause. Materials and Methods: 100 patients followed up in the Department of Neurology between 2019-2020 were included for the study.It was planned to scan the hospital files of the adult patient group using pregabalin. The data obtained as a result of possible changes in serum electrolyte levels and kidney functions of patients with pregabalin indication were evaluated. Peripheral blood urea, uric acid, creatinine, serum electrolyte levels of the patients were determined and glomerular filtration rate (GFR) was analyzed twice, in six months for possible changes in kidney functions. Results: Arithmetic mean values and changes were examined in patients who were measured twice in a six-month period. The effect of pregabalin use on urea and uric acid values, which are markers of renal function, was found to be statistically significant (p<0.05). There was no statistically significant effect on GFR, creatinine, Na+, Cl–, K+, Ca+2, Mg+2 and P+3 parameters (p>0.05). Conclusion: This study may be useful to investigate the effects of pregabalin on other organs. The data obtained may contribute to the provision of information that may be useful to drug research and development institutions and to increase drug safety.Öğe Effect of hypothalamic adrenal axis and thyroid function alterations on prognosis of critically Ill COVID-19 Patients(Galenos Publ House, 2024) Korkusuz, Muhammet; Karaburgu, Sulbiye; Et ,Tayfun; Yarımoğlu, Rafet; Kumru, NuhAim: The aim of this study was to evaluate the effect of changes in adrenal, and thyroid functions on the prognosis of Coronavirus disease-2019 (COVID-19) patients admitted to the intensive care unit (ICU). Materials and Methods: This was a retrospective evaluation that included COVID-19 patients requiring ICU admission. Serum cortisol, adrenocorticotrophic hormone (ACTH), thyroid-stimulating hormone (TSH), free thyroxine (fT4) and triiodothyronine (fT3) levels were measured on admission and two more times during the hospitalization. Routine biochemistry, hemogram, C-reactive protein, procalcitonin, fibrinogen and D-dimer levels were also measured, along with hormones. All-cause mortality during ICU stay, inotropic drug and mechanical ventilation needs, and duration of hospitalization were recorded for each patient. Euthyroid sick syndrome (ESS) and hypocortisolism rates were determined. Deceased and surviving patients were compared in terms of hormone values, and logistic regression to determine independent associates of mortality was performed. Results: Overall, 124 patients (58% male, mean age 70.7 +/- 11.3 years) were included. During the ICU stay, both fT3 and fT4, but not TSH, showed a statistically significant decrease compared to admission values. Serum cortisol and ACTH values increased compared to admission values, but this increase was not significant. ESS was present in 89.5% of the patients. Two-thirds of the patients died in ICU. Serum fT3 values were significantly lower among decedents compared to survivors. Hypocortisolism was detected in 20.1% of the patients. Only the fT3 level could independently and significantly predict all-cause mortality. Conclusion: ESS was almost universal among critically ill COVID-19 patients. Serum fT3, but not other thyroid or adrenal hormones, could significantly predict all-cause mortality.Öğe Can the neutrophil/lymphocyte*platelet ratio predict acute appendicitis? an analytical study(Galenos Publ House, 2024) Özkan, Abuzer; Özdemir, Serdar; Akça, Hatice Şeyma; Akça, Muhammed TahirAim: Our primary aim is to determine whether the neutrophil/lymphocyte*platelet ratio (NLPR) has the ability to predict acute appendicitis. Our secondary aim is to show whether the NLPR is effective in differentiating complicated and non -complicated acute appendicitis. Materials and Methods: Our study was planned retrospectively, and patients over 18 years of age who were diagnosed with acute appendicitis and admitted to the Health Sciences University Turkey, & Uuml;mraniye Training and Research Hospital between 01.04.2022 and 01.04.2023, were included in the study. Results: A total of 492 patients were included in our study, and 242 (49.18%) of them were diagnosed with acute appendicitis. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and NLPR were statistically significantly higher in patients with acute appendicitis compared to the control group (p<0.001, p<0.001, p<0.001, respectively) (the area under the curve was 0.96, 0.70, 0.94, respectively). Conclusion: NLR, PLR and NLPR can be used as predictors for the diagnosis of acute appendicitis, but according to our study, NLR, PLR and NLPR should not be used as prognostic indicators of acute appendicitis.Öğe Diagnostic role of serum testican and ubiquitin levels with head trauma(Mre Press, 2024) Yazıcı, Ramiz; Kalafat, Utku Murat; Atik, Dilek; Cander, BazarWe aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury (TBI).In this study, we conducted an observational and prospective study in the Emergency Department (ED) of a tertiary care hospital. The department admitted an average of 25,000 patients per month between October 2020 and March 2021. We focused on patients over 18 years old with moderate traumatic brain injury (Glasgow coma score (GCS): 9-13). We compared the prognostic values of blood testican and ubiquitin levels with Receiver Operating Characteristic (ROC) analysis for intracranial pathologies resulting from head trauma. Additionally, we used logistic regression analysis to compare the effectiveness of these markers in diagnosing intraparenchymal injury. The study included a total of 89 patients, with 45 in the case group (moderate TBI) and 44 in the healthy control group. It was found that levels of ubiquitin and testican levels were significantly higher in patients with intraparenchymal pathology (p p = 0.048, p = 0.046, respectively). The cut-off point for detecting intraparenchymal pathology was 161.3 pg/mL for testican (Area under curve (AUC): 0.810; min: 0.654; max: 0.965, p = 0.002) and 44.42 ng/mL for Ubiquitin (AUC: 0.863; min: 0.727; max: 1.000, p < 0.001). High testican-1 and ubiquitin levels were independent markers for intraparenchymal pathology in moderate head trauma.Öğe Topical 5% Dapsone Applied Twice Daily for Facial Acne Vulgaris: More Effective on Inflammatory Lesions and Quicker in Female Patients(2024) Özkoca, Defne; Caf, Nazlı; Özdil, Ayşenur; İmren, Işıl Göğem; Temiz, Selami Aykut; Metin, Mahmut Sami; Durmaz, KorayObjective: Topical 5% dapsone is an effective alternative in the treatment of facial acne vulgaris. The aim of this study is to determine the impact of gender and age of the patient on the treatment efficacy of dapsone gel, as well as its efficacy on types of lesions. Methods: Patients with mild-to-moderate facial acne vulgaris lesions, aged between 12 and 40 years of age were included in this multicenter study. Patients received 5% dapsone gel twice daily treatment for 8 weeks. Follow-up consultations were in weeks 2 and 8. The number of inflammatory and non-inflammatory lesions and the Global Evaluation of Acne Scale (GEAS) score of the patients were noted in each visit. Results: A negative correlation was found between age and the treatment response of inflammatory lesions in week 2 (rs = ?0.201; P = .008). Inflammatory lesions responded to treatment more compared to non-inflammatory lesions both on week 2 and week 8 (P-values both <.001). Female patients had a greater decline in both the number of inflammatory lesions and the total number of lesions on week 2 (P < .001 and P = .039 respectively). An at least 1 grade decline in the GEAS score was observed significantly more in the female patients on week 2 compared to male patients (P = .033). Conclusion: Topical dapsone is more effective in the treatment of inflammatory lesions than of the non-inflammatory lesions, and female patients have a quicker response.Öğe Prognostic Implications and Predictors of Mitral Regurgitancy Reduction After Transcatheter Aortic Valve Implantation(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Güney, Murat Can; Süygün, Hakan; Polat, Melike; Ayhan, Hüseyin; Keleş, Telat; Bozkurt, EnginBackground: Mitral regurgitation (MR) is a common condition observed in patients undergoing transcatheter aortic valve implantation (TAVI) for the treatment of aortic stenosis (AS). However, the impact of TAVI on MR outcomes and the factors predicting MR improvement remains uncertain. Understanding these predictors can enhance patient management and guide clinical decisions. Methods: This retrospective cohort study included 156 patients with moderate to severe MR undergoing TAVI. MR severity was assessed via echocardiography at baseline, as well as 6 months and 1 year after TAVI. Patients were divided into groups based on MR reduction: no improvement or worsening, one-degree improvement, and at least two-degree improvement. Clinical, echocardiographic, and procedural characteristics were evaluated as predictive factors for MR improvement after TAVI. Results: MR reduction occurred in 68% of patients at 6 months and 81% at 1 year. Factors predicting a reduction of two grades or more in MR severity included lower baseline LVEDD (OR = 1.345, 95% CI: 1.112–1.628, p = 0.002) lower baseline LA (OR = 1.121, 95% CI: 1.015–1.237, p = 0.024), lower baseline LVMI (OR = 1.109, 95% CI: 1.020–1.207, p = 0.024), and higher baseline EF levels (OR = 1.701, 95% CI: 1.007–2.871, p = 0.047). No significant association was found between MR reduction at 6 months and one-year mortality. (p = 0.65). Conclusions: Baseline echocardiographic parameters are valuable in predicting MR improvement post-TAVI, with LVMI emerging as a novel predictor. However, MR reduction did not independently predict survival, underscoring the need for further research to optimize patient selection and management strategies in TAVI candidates. © 2024 by the authors.Öğe Pediatric kidney care experience after the 2023 Türkiye earthquake(Oxford Univ Press Inc., 2024) Bakkaloglu, Sevcan A.; Delibaş, Ali; Döven, Serra Sürmeli; Taner, Sevgin; Yavuz, Sevgi; Erfidan, Gökçen; Elmacı, Ahmet MidhatBackground. Two earthquakes on 6 February 2023 destroyed 10 cities in Turkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. Method. Web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were recorded. Results. A total of 903 injured children (median age 11.62 years) were evaluated. Mean TUR was 13 h (interquartile range 32.5, max 240 h). Thirty-one of 32 patients with a TUR of >120 h survived. The patient who was rescued after 10 days survived. Two-thirds of the patients were given 50 mEq/L sodium bicarbonate in 0.45% sodium chloride solution on admission day. Fifty-eight percent of patients were given intravenous fluid (IVF) at a volume of 2000-3000 mL/m(2) body surface area (BSA), 40% at 3000-4000 mL/m(2) BSA and only 2% at >4000 mL/m(2) BSA. A total of 425 patients had surgeries, and 48 suffered from major bleeding. Amputations were recorded in 96 patients. Eighty-two and 66 patients required ventilator and inotropic support, respectively. Crush-AKI developed in 314 patients (36% of all patients). In all, 189 patients were dialyzed. Age >15 years, creatine phosphokinase (CK) >= 20 950 U/L, TUR >= 10 h and the first-day IVF volume <3000-4000 mL/m2 BSA were associated with Crush-AKI development. Twenty-two deaths were recorded, 20 of 22 occurring in patients with Crush-AKI and within the first 4 days of admission. All patients admitted after 7 days survived. Conclusions. These are the most extensive pediatric kidney disaster data obtained after an earthquake. Serum CK level was significantly associated with Crush-AKI at the levels of >20 950 U/L, but not with death. Adolescent age and initial IVF of less than 3000-4000 mL/m(2) BSA were also associated with Crush-AKI. Given that mildly injured victims can survive longer periods in the disaster field, we suggest uninterrupted rescue activity for at least 10 days.Öğe Intersecting pathways: evaluating inflammatory markers and metabolism in chronic spontaneous urticaria with a multi-marker approach(Wiley, 2024) Metin, Zuhal; Akça, Hanife Merve; Tur, Kaan; Akoğul, SerkanBackgroundChronic spontaneous urticaria (CSU) is an inflammatory skin disease with intricate mechanisms. This study comprehensively assessed markers from diverse metabolic pathways, including novel inflammatory indicators, to evaluate their potential for diagnosing and monitoring CSU.Materials and methodsIn the study involving 90 CSU patients and 90 healthy controls, the levels of albumin, high-density lipoprotein (HDL), fibrinogen, uric acid, D-dimer, C-reactive protein (CRP), and white blood cells (WBC) values were analyzed. The D-dimer/albumin ratio (DAR), fibrinogen/albumin ratio (FAR), and uric acid/HDL ratio (UHR), considered novel inflammatory markers, were calculated. The Urticaria Activity Score 7 (UAS7) was also calculated. Pearson chi-squared test, Mann-Whitney U test, Spearman correlation coefficient, and univariate logistic regression analysis were employed for data analysis.ResultsIn the patient group, significant elevations were observed in DAR, FAR, fibrinogen, CRP, D-dimer, and UHR values. Additionally, albumin, HDL, and uric acid values exhibited significant decreases. HDL and albumin provided the most accurate results in the univariate logistic regression analysis. CRP had less accuracy, FAR exhibited greater accuracy than fibrinogen, and DAR demonstrated higher accuracy than D-dimer. There was no statistically significant correlation between the UAS7 and parameters. The considerable correlation of CRP with other parameters, except D-dimer, was also remarkable.ConclusionsIndicators from diverse metabolic pathways, including albumin, HDL, uric acid, fibrinogen, D-dimer, and CRP, can be valuable in assessing CSU. In particular, FAR and DAR are emerging as potential markers to consider in the assessment of CSU.Öğe The prevalence, sociodemographic, and comorbidity characteristics of turkish children with cognitive disengagement syndrome(Istanbul Universitesi, 2024) Tahıllıoğlu, Akın; Bilaç, Öznur; Kardaş, Burcu; Kardaş, Ömer; Bolat, Gül Ünsel; Taşdemir, Ayşe IrmakObjective: Cognitive disengagement syndrome, formerly known as sluggish cognitive tempo, is defined as mental fogginess, daydreaming, and sluggishness. This study aimed to determine the prevalence and sociodemographic characteristics of children with cognitive disengagement syndrome and to examine the relationship between cognitive disengagement syndrome and psychiatric disorders. Methods: About 268 randomly chosen Turkish primary school children aged 7-11 years from 4 different cities were included in this study. Both teachers and parents completed the cognitive disengagement syndrome scanning scale of the Child Behavior Checklist and the Barkley Child Attention Survey. Psychiatric diagnoses in children were assessed using a semi-structured clinical interview. Four separate cognitive disengagement syndrome measurements were performed, matching informants with scales. Results: The prevalence of cognitive disengagement syndrome was estimated with a range of 4.9%-10.9%, depending on the way of measurement. Logistic regression analyses revealed that paternal psychopathology (odds ratio = 6.7) and low maternal education (odds ratio = 3.1) increased while advanced maternal age (odds ratio = 0.7) decreased the risk of cognitive disengagement syndrome. Although cognitive disengagement syndrome was found to be more prevalent in children with chronic diseases, this association no longer remained in the full logistic regression model. Attention-defic it/hyperactivity disorder was the most observed disorder and accompanied 42.9%-75% of the cases with higher cognitive disengagement syndrome. However, there was no strong support in favor of associations between cognitive disengagement syndrome and depression and anxiety as a whole. Conclusion: This study provides the first estimates regarding the prevalence and the sociodemographic characteristics of Turkish children with cognitive disengagement syndrome. Cognitive disengagement syndrome seems to be relatively more prevalent in Turkey than in Western cultures. Children whose fathers had a psychiatric disorder, whose mothers had low education, and who were at younger ages should be scrutinized for cognitive disengagement syndrome. © Author(s)-Available online at neuropsychiatricinvestigation.org.Öğe Lack of association of acne severity with depression, anxiety, stress, and eating attitudes: A cross-sectional study(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Karaağaç, Mustafa; Akça, Hanife Merve; Acat, ÖmerBackground: this study aimed to investigate the relationship between acne severity and depression, anxiety, stress, and negative eating attitudes in patients with acne vulgaris. Method: This study was conducted with 81 patients with acne vulgaris who applied to the dermatology outpatient clinic of Karaman Training and Research Hospital. The patients were asked to complete a sociodemographic data form, the three-factor nutrition questionnaire (TFEQ-21), and the depression anxiety stress scale (DASS-21). Acne severity was assessed using the global acne grading system (GAGS) by an expert dermatologist. Results: Of the 81 patients, 74.1% were female and the average age of the cohort was 22.86 years. The average body mass index of the patients was 21.78 and the GAGS average score was 24.25. Correlation tests revealed the lack of any relationship between the GAGS score and the DASS-21 and TFEQ-21 scale scores (and their subscales). The DASS-21 depression subscale was correlated with the TFEQ-21 total score, and TFEQ-21 emotional eating and TFEQ-21 uncontrolled eating scores. Additionally, a relationship was identified between the DASS21-stress subscale score and TFEQ-21 uncontrolled Eating and TFEQ-21 total score, as well as between the DASS21-anxiety scale and the TFEQ-21 total score and TFEQ-21 uncontrolled eating subscale score. Conclusions: Although no relationship was found between acne severity and depression, anxiety, or eating disorders, these conditions can increase the risk of eating disorders among acne patients. Therefore, it is critical to take the necessary precautions for the treatment of depression and anxiety disorders in this patient population.Öğe Validity and reliability of the Turkish version of the sleep condition indicator: a clinical screening instrument based on the dsm-5 criteria for insomnia(Dove Medical Press Ltd., 2024) Uygur, Hilal; Ahmed, Oli; Uygur, Omer Faruk; Miller, Christopher B.; Hurşitoğlu, Onur; Bahar, Aynur; Demiröz, DuduPurpose: We aimed to adapt the Turkish Sleep Condition Indicator (SCI) version and examine its psychometric properties among the general population. Methods: This study was a cross-sectional study. The item-total correlation, standard error of measurement, Cronbach’s α, and McDonald’s ω were used for internal consistency. We ran confirmatory factor analysis (CFA) and network analysis to confirm the factor structure. Multigroup CFA was run to assess the measurement invariance across gender, whether clinical insomnia or not, and poor sleep quality. We correlated SCI scores with Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI) scores to evaluate construct validity. A receiver operating characteristic (ROC) curve analysis was conducted to calculate the cut-off score of the SCI. The temporal stability was examined with the intraclass correlation coefficient. Results: Eight hundred thirty-four participants attended. Over half of the participants were women (63.2% n = 527); the mean age was 36.15 ± 9.64. Confirmatory factor and network analysis results show that the two-factor correlated model had a good model fit for the SCI. The SCI had scalar level invariance across gender, having clinical insomnia and poor sleep quality in the Multigroup CFA. ROC curve analysis shows that the SCI has good sensitivity (90.3%) and specificity (91.8%) for cut-off ≤ 15. The intraclass correlation coefficient computed between the first and second SCI total scores was significant (r=0.80 with a 95% confidence interval from 0.78 to 0.87; p < 0.001). Conclusion: The Turkish SCI is a practical self-reported insomnia scale with good psychometric properties that can be used to screen for insomnia disorder.Öğe Association Between the Success of Bariatric Surgery and Personality Traits(2023) İmre, Okan; Toprak, Şükrü SalihObjective: Acceptable preoperative psychosocial indicators of weight loss after obesity surgery in morbidly obese(MO) patients are still unknown. In this study, the association between personality traits, multidimensional perceived social support, and the percentage of excess weight loss (EWL) following obesity surgery was researched in MO patients. Methods: Participants in this prospective study were recruited from MO patients who applied to the hospital’s obesity unit between July 2021 and June 2022. The study comprised 84 MO individuals. The Temperament and Personality Inventory (TCI) was used to evaluate the personality traits of the MO. Perceived social support was measured using the multidimensional perceived social support scale. The percentage of weight loss after obesity surgery was compared with personality traits and perceived social support scores. Results: The mean age of the patients who were MO was 36.7 ±8.7 years. There were 22 men (25.3%) and 62 women (74.7%). The mean preoperative BMI was 46.2 ±63. The perceived social support score was 68.0±16.4. A univariate analysis found a positive relationship between 6 months and one year’s EWL and Self-Transcendence, a TCI subcategory (p=0.011,p=0.023). Conclusion: Obesity treatment is a complex situation that requires a multidisciplinary approach. Given the potential physiological and psychological consequences of obesity surgery, it is critical to uncover psychological predictive factors such as personality traits that boost the success of obesity surgery and are connected with weight loss. As a result, knowing the individuals who selftranscendence before obesity surgery may be useful in predicting the success of obesity surgery and planning treatment. This requires large-scale research.Öğe Bipolar bozuklukta ortalama trombosit hacmi, trombosit dağılım genişliği ve kırmızı hücre dağılım genişliği(2023) İmre, OkanBipolar bozukluk(BB), mani ve depresyon dönemleriyle karakterize arada düzelmelerin olduğu kronik bir bozukluktur. Son zamanlarda Bipolar bozukluğun(BB) patofizyolojisinde inflamatuar sistem üz erinde durulmaktadır. Ortalama trombosit hacmi(MPV), trombosit da ğılım genişliği(PDW) ve eritrosit dağılım genişliği(RDW) inflamasyon düzeyini ölçmek için önerilen, oldukça ucuz hematolojik biyobelirteçlerdir. Psikiyatri dışı hastalıklarda bu belirteçlerle ilgili çok sayıda çalışma yapıldığı halde, psikiyatrik hastalıklarda sınırlı sayıda araştırma vardır. Bu çalışmada BB farkl ı dönemlerindeki MPV, PDW, RDW değerleri araştırıldı. Gereç ve Yöntem: Retrospektif olan bu çalışmaya Karamanoğlu Mehmetbey Üniversitesi Tıp Fakültesi psikiyatri kliniğinde 01.01.2017-01.01.2022 tarihleri arasında BB nedeniyle yatırılan ve dahil edilme kriterlerini karşılayan 108(76 manik, 32 depresif) hasta al ındı. Ayn ı hastaların taburculuk sonrası ötimik dönemdeki verileri kaydedildi. BB’nin farklı evrelerinde MPV, PDW, RDW değerleri, sağlıklı kontrol grubu ile kıyaslandı. Bulgular: Tedavi öncesi mani ve depresif dönemdeki BB’ de PDW de ğerleri sağlıklı kontrol grubundan daha dü şük bulundu(medyan; 15.30, 15.50, 16.20). Aynı hasta gruplarının tedavi sonrası ötimik dönemlerindeki PDW de ğerleri de, sağlıklı kontrol grubundan daha dü şük bulundu(medyan; 15.65, 15.40, 16.20). BB manik dönem, tedavi sonrası ötimik döneme girdiğinde PDW değerlerinde yükselme görüldü(z= -2,107). BB depresif dönem, tedavi sonras ı ötimik döneme girdi ğinde RDW değerlerinde yükselme görüldü(z= -2,294). Sonuç: BB tüm dönemlerinde PDW dü şüklüğü, PDW’ nin bir özellik biyobelirteci olabileceğini düşündürmektedir. BB manik dönemden tedavi sonras ı ötimik döneme girdi ğinde PDW değerlerinde yükselme görülmesi, PDW yüksekliğinin, ötimik dönem için bir durum belirteci olabileceğini düşündürmektedir. BB depresif dönemin tedavisinden sonra PDW düşüklüğünün devam etmesi ve RDW de ğerinin yükselmesi, depresyon düzeldikten sonra devam eden baz ı eşik altı şikayetlerle ilişkili olabilir.Öğe Assessment of cardiac functions and subclinical cardiovascular risk in children with urolithiasis: A pilot study(2023) Alp, Hayrullah; Elmacı, Ahmet Midhat; Dönmez, Muhammet İrfanObjective: Information on cardiovascular problems related to childhood urinary stone disease is limited. The aim of this study was to assess the ventricular functions and subclinical cardiovascular risk in children with urolithiasis using echocardiographic measurements. Materials and Methods: Children diagnosed with urolithiasis were prospectively enrolled in the study as well as children with no urinary stone disease were confirmed via urinary ultrasonography. Body mass index and blood pressures were noted, as well as basic serum parameters. Carotid intima media thickness (cIMT), epicardial fat tissue (EFT) thickness and periaortic fat tissue (PFT) thickness were measured via transthoracic echocardiography in addition to pulsed and tissue Doppler imaging. Myocardial performance indexes were also calculated and correlation analyses were conducted. Results: A total of 17 patients (10 boys) with a mean age of 8.57±2.62 years were included in this study. There were 17 children (12 boys) in the control group and their mean age was 9.53±1.72 years. There was no statistically significant difference between the two groups in terms of demographic and laboratory variables. Tissue Doppler echocardiography revealed that Tei indexes of the left ventricle, right ventricle and septum were significantly higher in the study group than in the controls (p<0.001 for all). The cIMT (0.041±0.012 vs. 0.025±0.002), EFT (0.432±0.083 vs. 0.325±0.032) and PFT thicknesses (0.138±0.029 vs. 0.113±0.008) of the study group was statistically higher than the control group (p<0.001, p<0.001 and p=0.002, respectively) indicating a higher CVD risk. Conclusion: Children with urolithiasis had not only biventricular early systolic and diastolic dysfunction but also subclinical atherosclerosis at early ages. Cardiovascular complications should be considered in the follow-up and treatment of children with urolithiasis.Öğe Frontal QRS-T angle in predicting short-term mortality in patients with SARS-CoV 2 infection in emergency service: An analytical study(2023) Özdemir, Serdar; Gürlevik, Ercan; Altunok, İbrahim; Özkan, Abuzer; Akça, Hatice Şeyma; İşat, GökhanAim: Current study sought to examine relationship of frontal QRS-T angle with mortality and its ability to predict mortality. Material and Methods: This retrospective study was made in an education hospital with SARS-CoV 2 infected patients admitted to emergency service between 01/01/2021 and 07/01/2021. Patients were grouped as survivor and died according to 30-day all-cause mortality data. Groups were matched in footings of comorbidities, demographics, laboratory parameters and ECG findings. Receiver operating characteristic examination was used for evaluation of the ability of frontal QRS-T angle to predict short- term mortality. Results: The frontal QRS-T angle was greater in died group compared to the survivors (53 (25.5- 115.5) vs 28 (13-52) p<0.001). According to the receiver operating characteristic analysis, the cut-off and area under the curve were determined as 41.5 (sensitivity: 62.2%, specificity: 64.7%) and 0.659 (95% confidence interval: 0.606-0.713), respectively for frontal QRS-T angle for 30-day mortality. The odds ratio of frontal QRS-T angle (?41.5) was determined as 3.03 (95% confidence interval: 2.08-4.42). Conclusion: Frontal QRS-T angle is a predictor with high specificity for short-term mortality in the emergency department in with patients SARS-CoV 2 infection.
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