Investigation of phenolic composition, antioxidant capacity, and antidiabetic effect of ornithogalum Lanceolatum L.: An in vitro Study
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pamukkale Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Diabetes Mellitus is a global health problem that leads to macro- and microvascular diseases associated with hyperglycemia. Phytotherapy is one of the alternative ways to cope with this type of disease. The genus Ornithogalum is consumed as a wild edible plant and traditionally used for ailments. This study aims to investigate the phenolic composition using High-Performance Liquid Chromatography as well as antioxidant and antidiabetic effects using spectrophotometric method of Ornithogalum lanceolatum L. aerial parts and bulb. In order to determine the antioxidant capacity total phenolic content, total flavonoid content and DPPH and ABTS free radical scavenging activities were analyzed in O. lanceolatum. Moreover, in vitro inhibitory effects of the O. lanceolatum aerial parts and bulb on digestive enzymes were determined by evaluating the α-amylase and α-glucosidase activities. Protocatechuic acid was found to be the main compound in both plant parts. However, the amounts of the total phenolic acids and flavonoids were found higher in the aerial parts than those in bulb as well. Furthermore, O. lanceolatum aerial parts exhibited more radical scavenging activity than bulb. The α-amylase and α-glucosidase IC50 inhibition activities of aerial parts were found more efficient than those for bulb. It can be concluded that O. lanceolatum can enhance the antioxidant status and also can prevent nutraceutically postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase enzymes. These findings reveal the importance of traditional remedies in the ethnopharmacological use of herbs.
Açıklama
Anahtar Kelimeler
ABTS, Antidiabetic, α-glucosidase, DPPH, Ornithogalum Lanceolatum
Kaynak
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
8
Sayı
2
Künye
Temiz, M. A. (2021). Investigation of phenolic composition, antioxidant capacity, and antidiabetic effect of ornithogalum lanceolatum L.: An in vitro study. International Journal of Secondary Metabolite, 8(2), 94-103.
