Regulation of chaperone proteins in the retinoid pathway in human malignancies

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dc.authorscopusid57190064231
dc.contributor.authorKaraosmanoğlu O.
dc.date.accessioned2024-01-22T12:22:33Z
dc.date.available2024-01-22T12:22:33Z
dc.date.issued2023
dc.departmentKMÜen_US
dc.description.abstractNature is an abundant source of biologically active compounds. Carotenoids are natural products that exhibit provitamin A activity in the human body. Retinoids are chemicals that are related to vitamin A. Chaperone proteins in the retinoid pathway carry lipophilic retinoids and solubilize them in the aqueous environment of the cell. Dietary absorption, protection from oxidation, storage, metabolism, and the functions of retinoids are highly dependent on these chaperone proteins. This chapter first describes the relation of retinoids to carotenoids, continues by introducing the retinoid pathway, and finalizes with the expression, structure, and function of chaperone proteins that are involved in the retinoid pathway. The regulation of chaperone proteins in the retinoid pathway in cancer is particularly emphasized. Further translational studies that report the consequences of targeting chaperone proteins in the retinoid pathway for the treatment of cancer patients can reveal the potential of these proteins. © 2023 Elsevier B.V.en_US
dc.description.sponsorshipThe author is grateful to Prof. Dr. Sreeparna Banerjee (METU, Ankara, Turkey) for language editing of the chapter.en_US
dc.identifier.doi10.1016/B978-0-443-18961-6.00013-5
dc.identifier.endpage37en_US
dc.identifier.issn15725995
dc.identifier.scopus2-s2.0-85173130957
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-443-18961-6.00013-5
dc.identifier.urihttps://hdl.handle.net/11492/8044
dc.identifier.volume79en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofStudies in Natural Products Chemistryen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzkmusnmz
dc.subjectCanceren_US
dc.subjectCarotenoidsen_US
dc.subjectCellular retinoic acid binding proteinsen_US
dc.subjectCellular retinol-binding proteinsen_US
dc.subjectHuman malignanciesen_US
dc.subjectInterphotoreceptor retinol-binding proteinen_US
dc.subjectRetinoid pathwayen_US
dc.subjectRetinoidsen_US
dc.subjectRetinol-binding proteinsen_US
dc.titleRegulation of chaperone proteins in the retinoid pathway in human malignanciesen_US
dc.typeBook Part

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