Biological activities and biocompatibility properties of Eu(OH)3 and Tb(OH)3 nanorods: Evaluation for wound healing applications

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dc.authorid0000-0002-4813-7941en_US
dc.contributor.authorAvar Çınar, Eda
dc.contributor.authorTürkmen, Kübra Erkan
dc.contributor.authorErdal, Ebru
dc.contributor.authorLoğoğlu, Elif
dc.contributor.authorKatırcıoğlu, Hikmet
dc.date.accessioned2022-05-12T08:47:24Z
dc.date.available2022-05-12T08:47:24Z
dc.date.issued2022en_US
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000789745600002en_US
dc.description.abstractRare earth elements have shown promising results in both bio-imaging and therapy applications due to their superior magnetic, catalytic, and optical properties. In recent years, since lanthanide-based nanomaterials have effective results in wound healing, it has become necessary to investigate the different properties of these nanoparticles. The aim of this study is to investigate the antimicrobial, antibiofilm, and biocompability of Eu(OH)3 and Tb(OH)3 nanorods, which have a high potential by triggering angiogenesis and providing ROS activity, especially in wound healing. For this purpose, nanorods were obtained by the microwave-assisted synthesis method. Structural characterizations of Eu(OH)3 and Tb(OH)3 nanorods were performed by FT-IR, XRD, and TG–DTA methods, and morphological characterizations were performed by SEM–EDX. Microorganisms that are likely to be present in the wound environment were selected for the antimicrobial activities of the nanorods. The highest efficiency of nanorods with the disc diffusion method was shown against Pseudomonas aeruginosa ATCC 27,853 and Candida albicans ATCC 10,231 microorganisms. One of the problems frequently encountered in an infected wound environment is the formation of bacterial biofilm. Eu(OH)3 nanorods inhibited 77.5 ± 0.43% and Tb(OH)3 nanorods 76.16 ± 0.60% of Pseudomonas aeruginosa ATCC 27,853 biofilms. These results show promise for the development of biomaterials with superior properties by adding these nanorods to wound dressings that will be developed especially for wounds with microbial infection. Eu(OH)3 nanorods are more toxic than Tb(OH)3 nanorods on NCTC L929 cells. At concentrations of 500 µg/ml and above, both nanorods are toxic to cells.en_US
dc.identifier.citationÇinar Avar, E., Türkmen, K.E., Erdal, E. et al. Biological Activities and Biocompatibility Properties of Eu(OH)3 and Tb(OH)3 Nanorods: Evaluation for Wound Healing Applications. Biol Trace Elem Res (2022). https://doi.org/10.1007/s12011-022-03264-wen_US
dc.identifier.doi10.1007/s12011-022-03264-w
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid35501662
dc.identifier.scopus2-s2.0-85129303421
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03264-w
dc.identifier.urihttps://hdl.handle.net/11492/6311
dc.identifier.volume33en_US
dc.identifier.wosWOS:000789745600002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTürkmen, Kübra Erkan
dc.language.isoen
dc.publisherHumana Press Incen_US
dc.relation.journalBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEuropium Hydroxideen_US
dc.subjectTerbium Hydroxideen_US
dc.subjectNanoroden_US
dc.subjectWound Healingen_US
dc.subjectAntimicrobialen_US
dc.subjectAntibioflmen_US
dc.titleBiological activities and biocompatibility properties of Eu(OH)3 and Tb(OH)3 nanorods: Evaluation for wound healing applicationsen_US
dc.typeArticle

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