Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo

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dc.authorid0000-0002-6422-1203en_US
dc.contributor.authorPektaş, Gökhan
dc.contributor.authorPektaş, Suzan Demir
dc.contributor.authorÖztekin, Aynure
dc.contributor.authorÖztekin, Coşkun
dc.contributor.authorNeşelioğlu, Salim
dc.contributor.authorErel, Özcan
dc.contributor.authorSadi, Gökhan
dc.date.accessioned2019-12-06T21:15:20Z
dc.date.available2019-12-06T21:15:20Z
dc.date.issued2019
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000463592100007en_US
dc.description.abstractVitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological parameters, were determined. Results demonstrated that native and total thiol contents, and their ratios, were significantly lower in vitiligo patients. Disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the patient group. Progressivity of the disease strongly regulated the thiol/disulfide homeostasis in such a way that active vitiligo patients had reduced native and total thiol levels but increased disulfide/native thiol and disulfide/total thiol ratios. Moreover, there was a statistically significant negative correlation between both duration of the vitiligo and native and total thiol contents. As these results clearly demonstrated that thiol/disulfide homeostasis was shifted toward disulfide formation in patients with generalized vitiligo, determining the dynamic nature of thiol/disulfide homeostasis can be used to monitor disease progression.en_US
dc.description.sponsorshipHitit University and Yildirim Beyazit Universityen_US
dc.description.sponsorshipThis study was supported partially by Hitit University and Yildirim Beyazit University which kindly provided laboratory reagents and equipment.en_US
dc.identifier.citationPektaş, G., Pektaş S. D., Öztekin A., Öztekin C., Neşelioğlu S., Sadi G. (2019). Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo. Archives of Biological Sciences, 71, 1, 55-62.
dc.identifier.doi10.2298/ABS181003047P
dc.identifier.endpage62en_US
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85065495508
dc.identifier.scopusqualityQ3
dc.identifier.startpage55en_US
dc.identifier.urihttps://dx.doi.org/10.2298/ABS181003047P
dc.identifier.urihttps://hdl.handle.net/11492/2544
dc.identifier.volume71en_US
dc.identifier.wosWOS:000463592100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.institutionauthorSadi, Gökhan
dc.language.isoen
dc.publisherInst Bioloska Istrazivanja Sinisa Stankovicen_US
dc.relation.journalArchives of Biological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneralized Vitiligoen_US
dc.subjectNative Thiolen_US
dc.subjectDisulfideen_US
dc.subjectTotal Thiolen_US
dc.subjectHomeostasisen_US
dc.titleDynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligoen_US
dc.typeArticle

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