Apoptosis of hippocampus and cerebellum induced with brain ischemia reperfusion prevented by 3',4'-dihydroxyflavonol (DiOHF)

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dc.contributor.authorDaşdelen, Derviş
dc.contributor.authorSolmaz, Merve
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorErdoğan, Ender
dc.date.accessioned2025-01-12T17:19:50Z
dc.date.available2025-01-12T17:19:50Z
dc.date.issued2024
dc.departmentKMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractThe present study aimed to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on apoptosis in the cerebellum and hippocampus in rats with ischemia-reperfusion. A total of 38 Wistar albino male rats were used. Experimental groups were designed as Group 1-Sham; Group 2-Ischemia-reperfusion (IR), in which animals were anesthetized and carotid arteries ligated for 30 minutes (ischemia) and reperfused 30 minutes; Group 3- IR + DiOHF (10 mg/kg); Group 4- Ischemia + DiOHF (10 mg/kg) + reperfusion; Group 5-DiOHF + IR. DiOHF was supplemented as 10 mg/kg by intraperitoneal injection 30 minutes before IR. Following application, the animals were sacrificed under general anesthetic by cervical dislocation, and the cerebellum and hippocampus tissues were analyzed for apoptosis. IR significantly increased hippocampus and cerebellum apoptosis activity, confirmed by Hematoxylin-Eosin, TUNEL labeling, and Caspase-8 activity. However, these values were significantly suppressed by the administration of DiOHF, especially when used before the ischemia and reperfusion. The results of the study show that increased apoptosis in the cerebellum and hippocampus tissue was inhibited by intraperitoneal DiOHF supplementation.
dc.description.sponsorshipSelcuk University Scientific Research Coordinatorship [18401105]
dc.description.sponsorshipThis research has been supported by Selcuk University Scientific Research Coordinatorship (Project number is 18401105)
dc.identifier.citationDaşdelen, D., Solmaz, M., Moğulkoç, R., Baltacı, A. K., & Erdoğan, E. (2024). Apoptosis of hippocampus and cerebellum induced with brain ischemia reperfusion prevented by 3′,4′-dihydroxyflavonol (DiOHF). Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission, 99(5), 225–237. https://doi.org/10.1080/10520295.2024.2360496
dc.identifier.doi10.1080/10520295.2024.2360496
dc.identifier.endpage237
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5
dc.identifier.pmid38940209
dc.identifier.startpage225
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2360496
dc.identifier.urihttps://hdl.handle.net/11492/10234
dc.identifier.volume99
dc.identifier.wosWOS:001258524500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakPubMed
dc.institutionauthorDaşdelen, Derviş
dc.institutionauthoridDaşdelen, Derviş/0000-0002-2378-8780
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3',4'-dihydroxyflavonol
dc.subjectBrain IR
dc.subjectCaspase-8
dc.subjectCerebellum
dc.subjectHippocampus
dc.subjectRat
dc.subjectTUNEL
dc.titleApoptosis of hippocampus and cerebellum induced with brain ischemia reperfusion prevented by 3',4'-dihydroxyflavonol (DiOHF)
dc.typeArticle

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