Topical 5% Dapsone Applied Twice Daily for Facial Acne Vulgaris: More Effective on Inflammatory Lesions and Quicker in Female Patients

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dc.contributor.authorÖzkoca, Defne
dc.contributor.authorCaf, Nazlı
dc.contributor.authorÖzdil, Ayşenur
dc.contributor.authorİmren, Işıl Göğem
dc.contributor.authorTemiz, Selami Aykut
dc.contributor.authorMetin, Mahmut Sami
dc.contributor.authorDurmaz, Koray
dc.date.accessioned2025-01-12T17:14:58Z
dc.date.available2025-01-12T17:14:58Z
dc.date.issued2024
dc.departmentKMÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: Topical 5% dapsone is an effective alternative in the treatment of facial acne vulgaris. The aim of this study is to determine the impact of gender and age of the patient on the treatment efficacy of dapsone gel, as well as its efficacy on types of lesions. Methods: Patients with mild-to-moderate facial acne vulgaris lesions, aged between 12 and 40 years of age were included in this multicenter study. Patients received 5% dapsone gel twice daily treatment for 8 weeks. Follow-up consultations were in weeks 2 and 8. The number of inflammatory and non-inflammatory lesions and the Global Evaluation of Acne Scale (GEAS) score of the patients were noted in each visit. Results: A negative correlation was found between age and the treatment response of inflammatory lesions in week 2 (rs = ?0.201; P = .008). Inflammatory lesions responded to treatment more compared to non-inflammatory lesions both on week 2 and week 8 (P-values both <.001). Female patients had a greater decline in both the number of inflammatory lesions and the total number of lesions on week 2 (P < .001 and P = .039 respectively). An at least 1 grade decline in the GEAS score was observed significantly more in the female patients on week 2 compared to male patients (P = .033). Conclusion: Topical dapsone is more effective in the treatment of inflammatory lesions than of the non-inflammatory lesions, and female patients have a quicker response.
dc.identifier.citationDefne Özkoca, Nazlı Caf, Zuhal Metin, Ayşenur Özdil, Işıl Göğem İmren, Selami Aykut Temiz, Mahmut Sami Metin, Koray Durmaz, Hanife Merve Akça, Tuğba Kevser Uzunçakmak, & Zekayi Kutlubay. (2024). Topical 5% Dapsone Applied Twice Daily for Facial Acne Vulgaris: More Effective on Inflammatory Lesions and Quicker in Female Patients. Cerrahpaşa Medical Journal, 48(1), 46–49. https://doi.org/10.5152/cjm.2024.23010
dc.identifier.doi10.5152/cjm.2024.23010
dc.identifier.endpage49
dc.identifier.issn2687-1904
dc.identifier.issue1
dc.identifier.startpage46
dc.identifier.trdizinid1274035
dc.identifier.urihttps://doi.org/10.5152/cjm.2024.23010
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1274035
dc.identifier.urihttps://hdl.handle.net/11492/10022
dc.identifier.volume48
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAkça, Hanife Merve
dc.institutionauthoridAkça, Hanife Merve/0000-0001-8280-7470
dc.language.isoen
dc.relation.ispartofCerrahpaşa Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleTopical 5% Dapsone Applied Twice Daily for Facial Acne Vulgaris: More Effective on Inflammatory Lesions and Quicker in Female Patients
dc.typeArticle

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