Paramagnetic characterization and dosimetric properties of Airfix drug and its ingredients (Montelukast sodium, Sorbitol): An EPR and DFT study
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, radiation effect on an asthma drug Airfix and its ingredients (Montelukast sodium, Sorbitol) were analyzed by using EPR spectroscopy in the dose range of 10 Gy–30 kGy. The dependence of radiation-induced radicals on irradiation dose, temperature and time was investigated in detail. It has been determined that the radical observed predominantly in the Airfix structure originates from Sorbitol, and the characteristic features of this alkyl-type radical have been clearly defined using both experimental EPR and theoretical DFT methods. Dosimetric properties were investigated for all samples and it was suggested that Airfix drug and Sorbitol could be used as an EPR dosimeter through this radical agent which was determined to be very stable and sensitive to radiation. Moreover, it has been emphasized that other drugs containing Sorbitol excipient can also be used for dosimetric purposes in the dose range studied and even irradiation doses can be detected in case of radiation sterilization.
Açıklama
WOS:000792904100001
Anahtar Kelimeler
Alkyl Radical, Density Functional Theory (Dft), Epr Dosimetry, Montelukast Sodium, Sorbitol, Irradiation
Kaynak
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
195
Sayı
Künye
Ece, E., Taşdemir, H. U., Bıyık, R., Özmen, A., & Sayın, U. (2022). Paramagnetic characterization and dosimetric properties of airfix drug and its ingredients (montelukast sodium, sorbitol): An EPR and DFT study. Radiation Physics and Chemistry, 195 doi:10.1016/j.radphyschem.2022.110082
