A rapid responsive coumarin-naphthalene derivative for the detection of cyanide ions in cell culture

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dc.authorid0000-0001-8074-9510en_US
dc.authorid0000-0002-6315-3018en_US
dc.authorid0000-0002-0416-2870en_US
dc.contributor.authorAydın, Ziya
dc.contributor.authorKeskinateş, Mukaddes
dc.contributor.authorYılmaz, Bahar
dc.contributor.authorDurmaz, Mustafa
dc.contributor.authorBayrakçı, Mevlüt
dc.date.accessioned2022-08-08T06:27:25Z
dc.date.available2022-08-08T06:27:25Z
dc.date.issued2022en_US
dc.departmentKMÜ, Teknik Bilimler Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümüen_US
dc.descriptionWOS:000841161600003
dc.descriptionPubMed ID:35779572
dc.description.abstractCyanide ion (CN−) is widely used in many industrial processes; however, it causes several diseases in humans. Therefore, rapid and accurate detection of CN− is very important and urgent. In this study, a CN− sensor (MH-2) which was capable of detecting CN− ions in living cell was developed. MH-2 gives a rapid color change, absorbance and fluorescence response to CN− in the presence of the anions tested in the working system. The binding ratio between the sensor and CN− was demonstrated by some spectrophotometric methods and the sensing mechanism was investigated by NMR titration experiments, suggesting that MH-2 gives response to CN− via the nucleophilic addition reaction. The fluorescence detection limit and the absorbance detection limit were calculated as 0.056 μM and 0.11 μM, respectively. Both of these detection limits are below the tolerable limit recommended by WHO for CN− in the drinking water (1.9 μM). MH-2 was also applied to living cells for bio-imaging and the results showed that the sensor penetrates the cells and can detect cyanide ions in living cells.en_US
dc.identifier.citationAydın, Z., Keskinateş, M., Yılmaz, B., Durmaz, M., & Bayrakçı, M. (2022). A rapid responsive coumarin-naphthalene derivative for the detection of cyanide ions in cell culture. Analytical Biochemistry, 654 doi:10.1016/j.ab.2022.114798en_US
dc.identifier.doi10.1016/j.ab.2022.114798
dc.identifier.issn0003-2697
dc.identifier.pmid35779572
dc.identifier.scopus2-s2.0-85133430138
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ab.2022.114798
dc.identifier.urihttps://hdl.handle.net/11492/6490
dc.identifier.volume654en_US
dc.identifier.wosWOS:000841161600003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Ziya
dc.institutionauthorKeskinateş, Mukaddes
dc.institutionauthorBayrakçı, Mevlüt
dc.language.isoen
dc.publisherAcademic Press Inc.en_US
dc.relation.journalAnalytical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioimagingen_US
dc.subjectColorimetric Sensoren_US
dc.subjectCyanide Sensingen_US
dc.subjectFluorescent Sensoren_US
dc.titleA rapid responsive coumarin-naphthalene derivative for the detection of cyanide ions in cell cultureen_US
dc.typeArticle

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