Resveratrol ameliorates the components of hepatic ınflammation and apoptosis in a rat model of streptozotocin-ınduced diabetes
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Trans-resveratrol has a wide range of biological effects that reflect its antioxidant, anti-inflammatory, anticarcinogenic and cardioprotective properties. This study was conducted to elucidate the potential role of resveratrol on hepatic inflammation and the apoptotic pathway components Bcl-2, Bax and p53 in a streptozotocin (STZ)-induced rat model of diabetes mellitus. Inflammatory and apoptotic biomarkers indicated a reduction in hepatic erythropoietin (1.26-fold) and increased asymmetric dimethylarginine (3.9-fold), visfatin (1.6-fold), inflammatory interleukins and TNF- contents (approximately twofold each) in the diabetic animals. Induction of inducible nitric oxide synthase gene (2.04-fold) and protein expression (1.24-fold) was also observed. Immunohistochemical studies showed enhancement of the apoptotic biomarkers Bax and p53 in diabetic animals. STZ-induced diabetic male Wistar rats were treated with resveratrol (20 mg/kg/day i.p.). Resveratrol succeeded to recover most of these inflammatory and apoptotic elements. Therefore, inflammatory and apoptotic pathways were proved to be affected by STZ-induced diabetes in several aspects and resveratrol might contribute hepatoprotective effects as evidenced from this study. (c) 2016 Wiley Periodicals, Inc.
Açıklama
WOS:000370734000002
PubMed:26748675
PubMed:26748675
Anahtar Kelimeler
Diabetes, Resveratrol Liver, Inflammation, Bax, Bcl-2, p53
Kaynak
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
77
Sayı
1
Künye
Pektaş, M. B., Sadi, G., Koca, H. B., Yüksel, Y., Vurmaz, A., Koca, T., & Tosun, M. (2016). Resveratrol ameliorates the components of hepatic ınflammation and apoptosis in a rat model of streptozotocin-ınduced diabetes. Drug Development Research, 77, 1, 12-9.
