Resveratrol ameliorates the components of hepatic ınflammation and apoptosis in a rat model of streptozotocin-ınduced diabetes

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dc.authorid0000-0002-6422-1203en_US
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorSadi, Gökhan
dc.contributor.authorKoca, Halit Buğra
dc.contributor.authorYüksel, Yasemin
dc.contributor.authorVurmaz, Ayhan
dc.contributor.authorKoca, Tülay
dc.contributor.authorTosun, Murat
dc.date.accessioned2019-12-06T21:16:30Z
dc.date.available2019-12-06T21:16:30Z
dc.date.issued2016
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000370734000002en_US
dc.descriptionPubMed:26748675en_US
dc.description.abstractTrans-resveratrol has a wide range of biological effects that reflect its antioxidant, anti-inflammatory, anticarcinogenic and cardioprotective properties. This study was conducted to elucidate the potential role of resveratrol on hepatic inflammation and the apoptotic pathway components Bcl-2, Bax and p53 in a streptozotocin (STZ)-induced rat model of diabetes mellitus. Inflammatory and apoptotic biomarkers indicated a reduction in hepatic erythropoietin (1.26-fold) and increased asymmetric dimethylarginine (3.9-fold), visfatin (1.6-fold), inflammatory interleukins and TNF- contents (approximately twofold each) in the diabetic animals. Induction of inducible nitric oxide synthase gene (2.04-fold) and protein expression (1.24-fold) was also observed. Immunohistochemical studies showed enhancement of the apoptotic biomarkers Bax and p53 in diabetic animals. STZ-induced diabetic male Wistar rats were treated with resveratrol (20 mg/kg/day i.p.). Resveratrol succeeded to recover most of these inflammatory and apoptotic elements. Therefore, inflammatory and apoptotic pathways were proved to be affected by STZ-induced diabetes in several aspects and resveratrol might contribute hepatoprotective effects as evidenced from this study. (c) 2016 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T159]en_US
dc.description.sponsorshipFunding was partially provided by Scientific and Technological Research Council of Turkey (TUBITAK) with grant number of 112T159.en_US
dc.identifier.citationPektaş, M. B., Sadi, G., Koca, H. B., Yüksel, Y., Vurmaz, A., Koca, T., & Tosun, M. (2016). Resveratrol ameliorates the components of hepatic ınflammation and apoptosis in a rat model of streptozotocin-ınduced diabetes. Drug Development Research, 77, 1, 12-9.
dc.identifier.doi10.1002/ddr.21287
dc.identifier.endpage19en_US
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299
dc.identifier.issue1en_US
dc.identifier.pmid26748675
dc.identifier.scopus2-s2.0-84958120852
dc.identifier.scopusqualityQ2
dc.identifier.startpage12en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ddr.21287
dc.identifier.urihttps://hdl.handle.net/11492/2915
dc.identifier.volume77en_US
dc.identifier.wosWOS:000370734000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSadi, Gökhan
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.journalDrug Development Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectResveratrol Liveren_US
dc.subjectInflammationen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectp53en_US
dc.titleResveratrol ameliorates the components of hepatic ınflammation and apoptosis in a rat model of streptozotocin-ınduced diabetesen_US
dc.typeArticle

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