Synthesis of novel mono and bis-indole conduritol derivatives and their alpha/beta-glycosidase inhibitory effects

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dc.authorid0000-0003-2209-5402en_US
dc.contributor.authorÇavdar, Hüseyin
dc.contributor.authorTalaz, Oktay
dc.contributor.authorEkinci, Deniz
dc.date.accessioned2019-12-06T21:18:04Z
dc.date.available2019-12-06T21:18:04Z
dc.date.issued2012
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Kimya Bölümüen_US
dc.descriptionWOS: 000311425500044en_US
dc.descriptionPubMed: 23137433en_US
dc.description.abstractHere we synthesized four novel indole conduritol derivatives 1-4 for the first time in the literature and probed their biological activities with the alpha and beta-glucosidases. The compounds showed quite effective glucosidase inhibitory action. IC50 values of the compounds were compared with the known glucosidase inhibitor acarbose and it was determined that newly synthesized indole conduritols had more powerful effect against beta-glucosidase in addition to exhibiting moderate influence against alpha-glucosidase. Our molecules thus constitute an important starting point for the design and exploitation of novel glucosidase inhibitors since glucosidase inhibitors have widespread applications in the treatment of diabetes, viral infections, lysosomal storage diseases and cancers. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bmcl.2012.10.038
dc.identifier.endpage7503en_US
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.issue24en_US
dc.identifier.pmid23137433
dc.identifier.scopus2-s2.0-84870237734
dc.identifier.scopusqualityQ2
dc.identifier.startpage7499en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.bmcl.2012.10.038
dc.identifier.urihttps://hdl.handle.net/11492/3237
dc.identifier.volume22en_US
dc.identifier.wosWOS:000311425500044
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTalaz, Oktay
dc.language.isoen
dc.publisherPergamon-Elsevıer Scıence LtdCE LTDen_US
dc.relation.journalBıoorganıc & Medıcınal Chemıstry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConduritolen_US
dc.subjectIndoleen_US
dc.subjectGlucosidaseen_US
dc.subjectInhibitoren_US
dc.titleSynthesis of novel mono and bis-indole conduritol derivatives and their alpha/beta-glycosidase inhibitory effectsen_US
dc.typeArticle

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