Detector design for surgical guidance
[ X ]
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CRC Press-Taylor & Francis Group
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Occult, non-palpable tumor localization has always been a challenge for surgeons due to the difficulty of identifying the margins of the tumor, is indistinguishable from normal tissue, leading to situations requiring a re-excision. The conventional localization techniques rely heavily on preoperative imaging. The large size and long acquisition time associated with preoperative-imaging devices make them infeasible for intraoperative use. Registering preoperative imaging information with the anatomy of the patient real time in the operating room often is difficult and inaccurate. To provide a real-time guidance and let the surgeon track tumor and anatomy of the patient simultaneously requires a radiotracer taken up by the tumor and a hand-held or robotic-arm supported detection device. The radiotracer could be a material such as 123I-labeled CLR1404 that deposits in most tumors but not in normal tissues, and 99mTc-labeled nanoparticles injected to locate Sentinel Lymph Nodes (SLNs). This detector needs characteristics such as: a high energy resolution to distinguish the gamma emissions from the tumor-seeking agent (159 keV) from that from the SLNs (140 keV); a fine spatial resolution to resolve deeply seated nodes from each other and identify the margins of the tumor; a sufficient sensitivity to image the structures live-time in the OR; and a light weight to be handled easily. Hence, the detector selection, in terms of both its components (detector type, collimation type, and front-end electronics) and its characteristics (detector thickness, width, energy resolution, detection efficiency, sensitivity, and decay time), is very important. If the selected crystal is a scintillator, selection of the photon multiplication device is another important component as part of a compact and efficient photomultiplier device. The collimation of the detector affects most aspects of the detector and requires careful optimization. This chapter discusses design characteristics and development of an inorganic scintillator-based lanthanum bromide (LaBr3) detector unit based on the performance characteristics needed to accomplish the goal of radio-guided surgery.
Açıklama
WOS:000880289400007
Anahtar Kelimeler
Energy-Resolution Scintillator
Kaynak
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
Sayı
Künye
Bedir, M. E., Thomadsen, B. R. (2022). Detector Design for Surgical Guidance. Radiation Detection Systems, 141-161.
