Calcium Metabolism Markers and Their Effects on Mortality in COVID-19 Patients Admitted to Intensive Care Unit

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dc.authorscopusid57381849000
dc.authorscopusid56845899500
dc.authorscopusid55354431600
dc.contributor.authorKorkusuz M.
dc.contributor.authorKaraburgu S.
dc.contributor.authorEt T.
dc.date.accessioned2024-01-22T12:22:48Z
dc.date.available2024-01-22T12:22:48Z
dc.date.issued2023
dc.departmentKMÜen_US
dc.description.abstractTo evaluate the status of serum calcium, parathyroid hormone (PTH), and 25 (OH) vitamin D and their effects on mortality in patients with COVID-19 who were admitted to the intensive care unit (ICU). This was a retrospective chart review. Laboratory data at ICU admission included serum creatinine, corrected calcium, phosphorus, albumin, magnesium, among others. Same laboratory measurements were repeated two more times during hospitalization. The length of ICU stay, mortality, and need for mechanical ventilation were also recorded. Hypocalcemia, hypomagnesemia, and hypovitaminosis D rates were examined along with independent predictors of in-hospital mortality. A total of 100 patients were included. The median length of ICU stay was 11.0 days. Mortality rate was 52%. Rates of vitamin D insufficiency and deficiency were 29% and 52%, respectively. Thirty percent of patients had serum calcium levels less than normal. On admission, 11% of the patients had hypomagnesemia. Patients with hypomagnesemia had lower serum calcium levels compared to normomagnesemic patients (8.7±0.6 vs. 9.2±0.7 mg/dL, p=0.031). Serum PTH levels were significantly different between hypomagnesemic and normomagnesemic patients. In contrast, 25(OH)vitamin D levels were comparable in both hypomagnesemic and normomagnesemic patients. In multivariate analysis, only the need for mechanical ventilation remained as a significant predictor of in-hospital mortality. Hypocalcemia was less common compared to the literature, whereas Vitamin D deficiency was widespread. Serum magnesium level appeared as an important modifier of serum calcium levels in these patients. Hypocalcemia was not associated with COVID-19 disease severity or mortality. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.en_US
dc.identifier.doi10.5505/ejm.2023.24571
dc.identifier.endpage643en_US
dc.identifier.issn13010883
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85174045224
dc.identifier.scopusqualityQ4
dc.identifier.startpage632en_US
dc.identifier.trdizinid1263498
dc.identifier.urihttps://doi.org/10.5505/ejm.2023.24571
dc.identifier.urihttps://hdl.handle.net/11492/8146
dc.identifier.volume28en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesien_US
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzkmusnmz
dc.subjectCalciumen_US
dc.subjectCOVID-19en_US
dc.subjectMagnesiumen_US
dc.subjectParathyroid hormoneen_US
dc.subjectVitamin Den_US
dc.subject25 hydroxyvitamin Den_US
dc.subjectalbuminen_US
dc.subjectcalciumen_US
dc.subjectcreatinineen_US
dc.subjectmagnesiumen_US
dc.subjectparathyroid hormoneen_US
dc.subjectphosphorusen_US
dc.subjectprednisoneen_US
dc.subjectprocalcitoninen_US
dc.subjecttroponinen_US
dc.subjecttroponin Ien_US
dc.subjectvitamin Den_US
dc.subjectacute kidney failureen_US
dc.subjectageden_US
dc.subjectAlzheimer diseaseen_US
dc.subjectAPACHEen_US
dc.subjectArticleen_US
dc.subjectartificial ventilationen_US
dc.subjectcalcium metabolismen_US
dc.subjectchemiluminescence immunoassayen_US
dc.subjectchronic kidney failureen_US
dc.subjectchronic obstructive lung diseaseen_US
dc.subjectcohort analysisen_US
dc.subjectcongestive heart failureen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectepilepsyen_US
dc.subjectestimated glomerular filtration rateen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjecthypermagnesemiaen_US
dc.subjecthypertensionen_US
dc.subjecthypocalcemiaen_US
dc.subjecthypomagnesemiaen_US
dc.subjectin-hospital mortalityen_US
dc.subjectintensive care uniten_US
dc.subjectkidney functionen_US
dc.subjectmagnesium blood levelen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmortalityen_US
dc.subjectoutcome assessmenten_US
dc.titleCalcium Metabolism Markers and Their Effects on Mortality in COVID-19 Patients Admitted to Intensive Care Uniten_US
dc.typeArticle

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