The effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injury

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dc.contributor.authorAktaş, Abit
dc.contributor.authorYiğit, Funda
dc.contributor.authorDelibaş, Burcu
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorHamour, Hala Mahgoub
dc.contributor.authorKaya, Ayşenur
dc.date.accessioned2024-03-21T06:56:01Z
dc.date.available2024-03-21T06:56:01Z
dc.date.issued2024en_US
dc.departmentKMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionPMID: 38320670en_US
dc.descriptionWOS:001184048100001en_US
dc.description.abstractObjective: To test the protective effects of Garcinia kola and curcumin on the ganglion tissues of diabetic rats following the use of autologous vein graft in peripheral nerve transection injury. Methods: The sciatic nerve on the right side was transected, and anastomosis was performed between the proximal and distal ends using an autologous vein graft. Curcumin and Garcinia kola seed extract were administered daily by oral gavage. The ganglion tissues were harvested after a 90-day waiting period. Sensory neurons in the dorsal root ganglion at the L4 and L5 levels were used for stereological evaluations. Mean sensory neuron numbers were analyzed using a stereological technique. The size of the light and dark neurons was also estimated, and ultrastructural and immunohistochemical evaluations were performed. Results: A statistically significant difference in sensory neuron numbers was observed between the groups with and without Garcinia kola and curcumin applications. The immunohistochemical results showed that the s-100 protein is expressed selectively between cell types. Conclusion: The results of this study show that curcumin and Garicinia kola prevented sensory neuron loss in diabetic rats following transection injury to the sciatic nerve.en_US
dc.identifier.citationAktaş, A., Yiğit, F., Delibaş, B., Kaplan, A. A., Hamour, H. M., Marangoz, A. H., Kaya, A., Altun, G., & Kaplan, S. (2024). The effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injury. Journal of chemical neuroanatomy, 136, 102395. https://doi.org/10.1016/j.jchemneu.2024.102395en_US
dc.identifier.doi10.1016/j.jchemneu.2024.102395
dc.identifier.issn0891-0618
dc.identifier.pmid38320670
dc.identifier.scopus2-s2.0-85184612559
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2024.102395
dc.identifier.urihttps://hdl.handle.net/11492/8393
dc.identifier.volume136en_US
dc.identifier.wosWOS:001184048100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaya, Ayşenur
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.journalJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic Neuropathyen_US
dc.subjectDorsal Root Ganglionen_US
dc.subjectPhysical Disectoren_US
dc.subjectSciatic Nerve Transection Injuryen_US
dc.subjectStereologyen_US
dc.titleThe effects of Garcinia kola and curcumin on the dorsal root ganglion of the diabetic rat after peripheral nerve transection injuryen_US
dc.typeArticle

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