Evaluation of anticancer activities of novel facile synthesized calix[n]arene sulfonamide analogs

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dc.authorid0000-0002-6315-3018en_US
dc.authorid0000-0002-8049-7867en_US
dc.authorid0000-0002-0416-2870en_US
dc.contributor.authorYılmaz, Bahar
dc.contributor.authorBayraç, Abdullah Tahir
dc.contributor.authorBayrakcı, Mevlüt
dc.date.accessioned2019-12-26T08:31:55Z
dc.date.available2019-12-26T08:31:55Z
dc.date.issued2019en_US
dc.departmentKMÜ, Mühendislik Fakültesi, Biyomühendislik Bölümüen_US
dc.descriptionWOS:000499232500005en_US
dc.description.abstractHere, new calixarene sulfonamide analogs were synthesized from the reaction of chlorosulfonated calix[n]arene (n: 4, 6, and 8) with N,N′-dimethylethylenediamine or ethylenediamine for the first time and an excellent calixarene sulfonamide analog showing potent and selective cytotoxic activity on some cancer cell lines were discovered. Cytotoxicity of the prepared calix[n]arene sulfonamide analogs towards both cancer and healthy cell lines was assessed by performing cell growth inhibition assays. In cytotoxicity assay results, it was observed that while sulfonamide analog based calix[4]arene (9) was not affecting the growth of epithelial cell lines (HEK), and it was especially effective on inhibiting the growth of some human cancer cell lines (MCF-7 and MIA PaCa-2). These results highlight that sulfonamide analog–based calix [4] arene (9) can be further studied as a potential anticancer agent.en_US
dc.identifier.citationYilmaz, B., Bayrac, A. T., & Bayrakci, M. (November 28, 2019). Evaluation of Anticancer Activities of Novel Facile Synthesized Calix[n]arene Sulfonamide Analogs. Applied Biochemistry and Biotechnology. 1-14.en_US
dc.identifier.doi10.1007/s12010-019-03184-x
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.pmid31782087
dc.identifier.scopus2-s2.0-85075856008
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s12010-019-03184-x
dc.identifier.urihttps://hdl.handle.net/11492/3245
dc.identifier.wosWOS:000499232500005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Bahar
dc.institutionauthorBayraç, Abdullah Tahir
dc.institutionauthorBayrakcı, Mevlüt
dc.language.isoen
dc.publisherSpringer (part of Springer Nature)en_US
dc.relation.journalApplied Biochemistry and Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitak116Z979
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalixareneen_US
dc.subjectSulfonamideen_US
dc.subjectAnticanceren_US
dc.subjectBreast Canceren_US
dc.subjectPancreatic Canceren_US
dc.titleEvaluation of anticancer activities of novel facile synthesized calix[n]arene sulfonamide analogsen_US
dc.typeArticle

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