The potential histopathological effect of sunset yellow fcf on lungs and hearts of developing mice

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dc.contributor.authorŞensoy, Erhan
dc.date.accessioned2025-03-25T12:49:12Z
dc.date.available2025-03-25T12:49:12Z
dc.date.issued2025
dc.departmentKMÜ, Sağlık Bilimleri Fakültesi, Ebelik Bölümü
dc.description.abstractPurpose: Existing research on the effects of azo dyes on human health is insufficient and often contradictory. Children are more exposed to the negative effects of food dyes than adults because they consume more foods and drinks containing food dyes. The research aimed to address the potential histopathological impacts of Sunset Yellow on the lungs and hearts of developing mice. Design/methodology/approach: About36 adult male Swiss albino mice were separated into six groups (n: 6). The groups were created, including three treatment groups (four, eight and 10 weeks old) and three control groups. Sunset Yellow (a dose level of 30 mg/kg/bw) per week was administered orally for 28 days to the treatment groups, while the control groups were not treated. On the final day of the research, the mice were sacrificed by cervical dislocation, and their lungs and hearts were removed. The tissues were preserved in 10% formaldehyde and processed through a series of alcohol and xylene. Then they were dyed with hematoxylin-eosin and evaluated under light and electron microscopy. Findings: Sunset Yellow caused significant increases in mean body weight (p: 0.013), lung weight (p: 0.011) and heart weight (p: 0.049). Hemorrhage, inflammation and vacuole formation were detected in lung tissue, while severe hemorrhage, vacuoles and degenerated cells were observed in heart muscle tissue. Notably, the histopathological changes in lung and heart tissues were more pronounced during the weaning period. Sunset Yellow induced histopathological and physiological abnormalities in the lungs and hearts of mice, suggesting it may adversely affect lung and heart development during weaning and adolescence. Therefore, restricting the use of Sunset Yellow may be warranted in early life stages. Research limitations/implications: Finally, as all studies have limitations, the research has limitations. The limitation of this study is the SY dose applied. Although the selected dose was determined based on the Acceptable Daily Intake (ADI) value used as a reference, investigating the effects of SY at different doses could be beneficial. Additionally, different analytical methods could be applied, and the results could be compared. In today’s society, challenges include a lack of knowledge about the effects of daily consumption of SY on health, limited and outdated resources on the subject and scarcity of field research. Originality/value: Sunset Yellow may be especially harmful during adolescence and adulthood. Highlights: • Sunset Yellow (SY) affected the lungs and hearts of mice developing.• SY caused a rise in the average bodyweight and relative organ weights.• Degeneration noted in lungs and hearts of all age groups of mice.• SY may be especially harmful during childhood and youth. Graphical abstract: (Figure presented.) © 2025, Emerald Publishing Limited.
dc.identifier.doi10.1108/BFJ-06-2024-0580
dc.identifier.issn0007070X
dc.identifier.urihttps://doi.org/10.1108/BFJ-06-2024-0580
dc.identifier.wosWOS:001443264300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Sceince
dc.institutionauthorŞensoy, Erhan
dc.institutionauthoridŞensoy, Erhan/0000-0003-2989-459X
dc.language.isoen
dc.publisherEmerald
dc.relation.ispartofJournal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSunset Yellow
dc.subjectDeveloping
dc.subjectMice
dc.subjectLung
dc.subjectHeart
dc.titleThe potential histopathological effect of sunset yellow fcf on lungs and hearts of developing mice
dc.typeArticle

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