Evaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cells

Basit Öğe Kaydı
dc.authorid0000-0002-9636-2596en_US
dc.authorid0000-0002-6422-1203en_US
dc.authorid0000-0002-6855-0645en_US
dc.authorid0000-0002-1420-6259en_US
dc.contributor.authorEmsen, Buğrahan
dc.contributor.authorSadi, Gökhan
dc.contributor.authorBostancı, Aykut
dc.contributor.authorGürsoy, Nuray
dc.contributor.authorEmsen, Ayça
dc.contributor.authorAslan, Ali
dc.date.accessioned2021-02-25T11:16:14Z
dc.date.available2021-02-25T11:16:14Z
dc.date.issued2021en_US
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000617843200001en_US
dc.description.abstractMany lichen secondary metabolites contributed to the field of pharmacology as an active ingredient of different drugs for years. In the present study, we aimed to test the anticancer activity of olivetoric acid (OA), which we isolated from Pseudevernia furfuracea (L.) Zopf in human hepatocellular carcinoma cells (HepG2). In addition, we used non-tumoral human liver cells (THLE2) to test the level of side effects of OA in vitro. For this purpose, cytotoxic (apoptotic and necrotic), oxidant, genotoxic activities and expression levels of apoptotic genes caused by different concentrations (12.5-400 mg/L) of OA were tested on both cells. Flow cytometric and cytotoxicity tests (MTT and LDH) revealed that OA (100-400 mg/L) had a higher rate of apoptotic effects on HepG2 cells compared to THLE2. Total oxidative stress and oxidative DNA damage levels caused by all concentrations of OA on HepG2 cells was significantly (p < 0.05) higher compared to negative control. Trials with concentrations of 100-400 mg/L significantly (p < 0.05) increased total antioxidant capacity on THLE2 cells compared to the control group. As a result, based on human hepatocellular carcinoma, it is hoped that OA may contribute to the combined or alternative treatment process.en_US
dc.identifier.citationEmsen, B., Sadi, G., Bostancı, A. et al.(2021). Evaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cells. Rendiconti Lincei-Scıenze Fısıche E Naturali.doi:10.1007/s12210-021-00976-4en_US
dc.identifier.doi10.1007/s12210-021-00976-4
dc.identifier.issn2037-4631
dc.identifier.issn1720-0776
dc.identifier.scopus2-s2.0-85100863943
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s12210-021-00976-4
dc.identifier.urihttps://hdl.handle.net/11492/4916
dc.identifier.wosWOS:000617843200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.institutionauthorEmsen, Buğrahan
dc.institutionauthorSadi, Gökhan
dc.institutionauthorBostancı, Aykut
dc.institutionauthorGürsoy, Nuray
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.journalRendiconti Lincei-Scıenze Fısıche E Naturalien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitak117Z632
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject8-OH-dGen_US
dc.subjectActive Ingredienten_US
dc.subjectApoptosisen_US
dc.subjectLactate Dehydrogenaseen_US
dc.subjectNecrosisen_US
dc.subjectqRT-PCRen_US
dc.titleEvaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cellsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Emsen, Bugrahan.pdf
Boyut:
3.01 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Kamil Özdağ Fen Fakültesi, Biyoloji Bölümü, Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu