Protective effect of celtis tournefortii against copper-induced toxicity in rat liver

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dc.authorid0000-0002-4680-3023en_US
dc.contributor.authorTemiz, Mehmet Ali
dc.contributor.authorTemur, Atilla
dc.contributor.authorAkgeyik, Yusuf
dc.contributor.authorUyar, Ahmet
dc.date.accessioned2021-05-10T13:01:24Z
dc.date.available2021-05-10T13:01:24Z
dc.date.issued2021en_US
dc.departmentKMÜ, Teknik Bilimler Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümüen_US
dc.descriptionWOS:000654628800012en_US
dc.description.abstractThis study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), Copper + C. tournefortii (Cu+Ct), and C. tournefortii (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, glutathione (GSH) concentration, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) were analysed in the liver tissues. Liver histopathology was also evaluated. Alanine aminotransferase and lactate dehydrogenase significantly decreased in the Cu+Ct group compared with the Cu group. Oxidative stress parameters MDA and TOS significantly increased with copper administration, whereas they decreased with C. tournefortii co-treatment compared to Cu group. GSH concentration and TAS showed significant decreases with copper administration. Celtis tournefortii co-supplementation with copper significantly enhanced antioxidant parameters such as TAS, SOD, and GPx. Celtis tournefortii remarkably attenuated degenerative and necrotic changes caused by the oral exposure of copper in the liver tissue of rats. Celtis tournefortii may provide amelioration of the antioxidant status and moderation of severity of liver damage against copper toxicity. The therapeutic use of C. tournefortii may exhibit protective effects in liver injury treatment.en_US
dc.description.sponsorshipThis research was supported by the Van Yuzuncu Yil University Scientific Research Projects Foundation (grant number FYL-2016-5479).en_US
dc.identifier.citationTemiz, M. A., Temur, A., Akgeyik, Y., & Uyar, A. (2021). Protective effect of celtis tournefortii against copper-induced toxicity in rat liver. Acta Veterinaria Brno, 90(1), 91-98. doi:10.2754/avb202190010091en_US
dc.identifier.doi10.2754/avb202190010091
dc.identifier.endpage98en_US
dc.identifier.issn00017213
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85104707334
dc.identifier.scopusqualityQ3
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.2754/avb202190010091
dc.identifier.urihttps://hdl.handle.net/11492/4999
dc.identifier.volume90en_US
dc.identifier.wosWOS:000654628800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.institutionauthorTemiz, Mehmet Ali
dc.language.isoen
dc.publisherUniversity of Veterinary and Pharmaceutical Sciencesen_US
dc.relation.journalActa Veterinaria Brnoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectHepatoprotectiveen_US
dc.subjectOriental Hackberryen_US
dc.subjectPhytochemicalsen_US
dc.subjectTASen_US
dc.subjectTOSen_US
dc.titleProtective effect of celtis tournefortii against copper-induced toxicity in rat liveren_US
dc.typeArticle

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