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  • Küçük Resim
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    Current compherensive approach to Covid-19
    (Duvar Kitapevi, 1/06/2022) Koksoy, Hale; Rağbetli, Murat Çetin; Alp, Harun; Ecesoy, Hilal; Basaran, Aynur; Kaya, Aysenur; Sahin, Ali; Bekci, Taha Tahir; Yesildag, Ahmet; Ecesoy, Volkan; Kocabas, Rahim; Karaburgu, Sülbiye; Ay, Mehmet Emre; Dulger, Ozlem; Osmanoglu, Omer Usame; Serin, Aliye Nigar; Ragbetli, Cennet; Kose, Fulya; Atik, Dilek; Kılıc, Nuray; Mustu, Mehmet; Alkan, Gulsum; Arıcı, Hasan; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, Hale
    This book, prepared by our Karamanoglu Mehmetbey and other faculty members by adding their current experiences during the pandemic process, is one of the leading scientific publications about the COVID-19 pandemic.
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    Current perspective on diabetes mellitus in clinical sciences
    (Nobel Tıp Bookstores, 30/09/2023) Alp, Harun; Sahin, Ali; Karabaglı, Pınar; Karaburgu, Sulbiye; Yılmaz Sanal, Burcu; Yuksel, Emine Berrin; et al.; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, Hale
    Diabetes Mellitus (DM) receives significant attention from most scientists due to being a major global public health threat. Diabetes is considered one of the leading causes of death due to its micro and macrovascular complications. This insidious killer is estimated to reach a staggering number of 578 million (700 million by 2045) cases by 2030. In this book, utilizing the disciplines of clinical sciences, various contemporary topics related to diabetes are extensively discussed. These include the classification of diabetes, underlying causes, epidemiology, pathogenesis, impact on sexual functions, association with cancer, clinical manifestations, diagnostic methods, complications, and treatment options. Furthermore, intriguing and current subjects such as "antidiabetic phytotherapy" and "the relationship between oral health and diabetes" are also covered. By doing so, readers will acquire comprehensive and detailed knowledge about the clinical management of diabetes. Thus, this book not only serves those who seek to understand the scientific aspects of diabetes but also proves to be a valuable resource for healthcare professionals, researchers, and students in a clinical setting. We believe that this book will contribute to understanding the complexity of diabetes and provide beneficial solutions while shedding light on future studies.
  • Küçük Resim
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    Investigating of effects of metformin on melanoma skin cancer
    (2021) Alp, Harun; Tutun, Hidayet; Altıntaş, Levent; Kaplan, Halil Mahir; Şingirik, Ergin; Kahraman, İbrahim
    Apoptotic pathways are important for resistance to chemotherapeutics drugs and cancer development. Metformin is a safe, inexpensive and effective drug used to treat type 2 diabetes. Furthermore, although there is evidence of anticancer effects, the mechanisms by which metformin exerts the effects are unclear. Therefore, it was aimed to investigate Bcl-2, kaspaz-3, bax, wee-1, AIF, grp78 and gadd153 levels in metformin treated skin cancer cells. Materials and Methods: The skin cancer cells (B16F10) were treated with metformin and kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF levels were analyzed by using ELISA. Result: Treatment of metformin increased of proapoptotic proteins (kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF) and decreased antiapoptotic protein (bcl2). Conclusion: In conclusion, this study showed that metformin has apoptotic effect on melanoma skin cancer.