Yazar "Aydin, Duygu" seçeneğine göre listele

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    Nanomolar level colorimetric and On-Off fluorimetric sensing of Cu2+: Theoretical, Smartphone, test kit and food application outcomes
    (Elsevier Science Sa, 2024) Yasar, Ozlem Guctekin; Aydin, Duygu; Elmas, Sukriye Nihan Karuk; Arslan, Fatma Nur
    A novel naphthaldehyde-based colorimetric and fluorogenic molecular sensor PHNAP [(E)-1-(((4-(phenylamino)phenyl)imino)methyl)naphthalen-2-ol] was developed for the recognition of Cu2+ with outstanding selectivity. After treatment with Cu2+, the PHNAP showed remarkable color transforms from yellow to colorless under UV-cabin and yellow to pink under daylight. Under the optimum sensing conditions, Cu2+ was selectively recognized and sensitively determined with a nanomolar detection limit (6.61 nM; 3 sigma/K). The PHNAP showed very fast and Cys-reversible response for Cu2+. The Job's plot and TOF-MS data were gathered to authenticate the mechanism of the binding. The DFT calculations also confirmed the proposed sensing phenomenon. Furthermore, PHNAP-based portable test kits were simply fabricated for the visual recognition of Cu2+. The PHNAP was used in diverse samples for the quantitatively recognition of Cu2+; likewise, the smartphone appliance was successfully performed without the aid of any sophisticated tool and the outstanding visual response of PHNAP.
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    Nanomolar Turn-On Hg2+ detection by a fluorescein based fluorescent probe: DFT calculations, bioimaging and on-site assay kit studies
    (Elsevier Science Sa, 2023) Erdemir, Serkan; Aydin, Duygu; Kocyigit, Ozcan
    Sensitive yet rapid methodologies for efficient recognition of toxic heavy metals, like Hg2+, would avert the poisonous impacts of these elements on the environment and human health. Herein, we present a highly selective fluoresceine-based fluorogenic probe FP for Hg2+ recognition with quick response, an impressive LOD of 67.1 nM, high sensitivity, and a linear emission increment relationship with Hg2+ concentration (0-20.0 mu M). FP could specifically recognize Hg2+ and it exhibited a 250-fold emission enhancement at 515 nm to Hg2+, but no response to other common cations. The mechanism for FP-Hg2+ was completely examined through FTIR, 1H NMR, TOF-MS, and density functional theory (DFT) calculations. To examine naked-eye recognition of Hg2+, the FP-coated silica plates, and cotton swabs were productively manufactured for the sensing of Hg2+. Besides, FP was able to recognize Hg2+ in biological systems with excellent efficiency. Overall, ultra-fast recognition property of FP for Hg2+, high sensitivity, and selectivity of FP against Hg2+ could be conveniently utilized to prevent the toxicity of Hg2+.
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    Phenolphthalein based molecule as a lighting-up fluorescent chemoprobe for the nanomolar recognition of Al3+: DFT study and its applications in test kits, food and water samples
    (Elsevier Science Sa, 2024) Aydin, Duygu; Elmas, Sukriye Nihan Karuk; Arslan, Fatma Nur
    Phenolphthalein-based compound (PHAB) was synthesized, well-characterized and studied as a lighting-up fluorescent chemosensor for Al3+. Fluorescence studies were performed at 25 degrees C in H2O/CH3CN (20/80, v/v) media. Free PHAB was non-fluorescent; but, it depicted a strong fluorescence toward Al3+ at 468 nm over potential competitive cations. The mechanism of C = N isomerisation and blocking PET enhanced its emission with a remarkable color alteration from colorless to blue. The LOD value was found at nano-molar level (51.5 nM), indicating high sensitivity toward Al3+. The validation study also confirmed the sensing performance of PHAB based on different analytical parameters. Job's plot, 1H NMR titration and MALDI TOF-MS studies authenticated the stoichiometry between PHAB and Al3+ (1:2). The binding of PHAB with Al3+ was further verified by the theoretical study. Furthermore, the fluorescence sensing performance of PHAB makes it perfect for practical applications in drinkable water and food samples with satisfactory recovery values (91.42%- 108.8%), as well as in simple test-kit applications.