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Öğe Beyond expectations: disease duration and psychological burden in psoriatic arthritis(Springer Science and Business Media Deutschland GmbH, 2023) Kılıç, Gamze; Kılıç, Erkan; Tekeoğlu, İbrahim; Sargın, Betül; Cengiz, Gizem; Balta, Nihan Cüzdan; Ecesoy, HilalThis study aims to investigate the relationship between disease duration and psychological burden in PsA and to identify the risk factors associated with psychological distress. Patients with PsA who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism (TLAR)-Network. Patients were categorized into three groups based on disease duration: early stage (< 5 years), middle stage (≥ 5, < 10 years), and late stage (≥ 10 years). All patients underwent clinical and laboratory assessment using standardized protocol and case report forms. The associations between psychological variables and clinical parameters were assessed by a multivariate analysis. Of the 1113 patients with PsA (63.9% female), 564 (%50.7) had high risk for depression and 263 (%23.6) for anxiety. The risk of psychological burden was similar across all PsA groups, and patients with a higher risk of depression and anxiety also experienced greater disease activity, poorer quality of life, and physical disability. Multivariate logistic regression revealed that female gender (OR = 1.52), PsAQoL (OR = 1.13), HAQ (OR = 1.99), FiRST score (OR = 1.14), unemployment/retired (OR = 1.48) and PASI head score (OR = 1.41) were factors that influenced the risk of depression, whereas the current or past enthesitis (OR = 1.45), PsAQoL (OR = 1.19), and FiRST score (OR = 1.26) were factors that influenced the risk of anxiety. PsA patients can experience a comparable level of psychological burden throughout the course of their disease. Several socio-demographic and disease-related factors may contribute to mental disorders in PsA. In the present era of personalized treatment for PsA, evaluating psychiatric distress can guide tailored interventions that improve overall well-being and reduce disease burden.Öğe The clinical, functional, and radiological features of hand osteoarthritis: TLAR-osteoarthritis multi-center cohort study(Turkish League Against Rheumatism, 2022) Duruöz, Mehmet Tuncay; Gürsoy, Didem Erdem; Tuncer, Tiraje; Ecesoy, Hilal; Altan, Lale; Ayhan, FigenObjectives: This study aims to evaluate the clinical, functional, and radiological features of hand osteoarthritis (OA) and to examine their relationships in different geographic samples of the Turkish population. Patients and methods: Between April 2017 and January 2019, a total of 520 patients (49 males, 471 females; mean age: 63.6 +/- 9.8 years) with hand OA were included in the study from 26 centers across Turkey by the Turkish League Against Rheumatism (TLAR). The demographic characteristics, grip strengths with Jamar dynamometer, duration of hand pain (month), the severity of hand pain (Visual Analog Scale [VAS]), and morning stiffness were evaluated. The functional disability was evaluated with Duruoz Hand Index (DHI). The Kellgren-Lawrence (KL) OA scoring system was used to assess the radiological stage of hand OA. Results: The DHI had significant correlations with VAS-pain (r=0.367, p<0.001), duration of pain (r=0.143, p=0.001) and bilateral handgrip strengths (r=-0.228, p=0.001; r=-0.303, p<0.001). Although DHI scores were similar between the groups in terms of the presence of hand deformity (p=0.125) or Heberden's nodes (p=0.640), the mean DHI scores were significantly higher in patients with Bouchard's nodes (p=0.015). The total number of nodes had no significant correlations with the VAS-pain and DHI score (p>0.05). The differences between the groups of radiological hand OA grades in terms of age (p=0.007), VAS-pain (p<0.001), duration of pain (p<0.001), and DHI (p<0.001) were significant. There were no significant differences between radiological hand OA grades according to the duration of the stiffness, grip strength, and BMI (p>0.05 for all). Conclusion: In our population, the patients with hand OA had pain, functional disability, and weak grip strength. The functional impairment was significantly correlated with the severity of the pain, and the functional status was worse in high radiological hand OA grades.Öğe Current compherensive approach to Covid-19(Duvar Kitapevi, 1/06/2022) Koksoy, Hale; Rağbetli, Murat Çetin; Alp, Harun; Ecesoy, Hilal; Basaran, Aynur; Kaya, Aysenur; Sahin, Ali; Bekci, Taha Tahir; Yesildag, Ahmet; Ecesoy, Volkan; Kocabas, Rahim; Karaburgu, Sülbiye; Ay, Mehmet Emre; Dulger, Ozlem; Osmanoglu, Omer Usame; Serin, Aliye Nigar; Ragbetli, Cennet; Kose, Fulya; Atik, Dilek; Kılıc, Nuray; Mustu, Mehmet; Alkan, Gulsum; Arıcı, Hasan; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, HaleThis book, prepared by our Karamanoglu Mehmetbey and other faculty members by adding their current experiences during the pandemic process, is one of the leading scientific publications about the COVID-19 pandemic.Öğe Is procalcitonin elevation always an indicator of bacterial infection?(Turkish League Against Rheumatism (TLAR), 2024) Ecesoy, Volkan; Ecesoy, HilalAdult-onset Still’s disease is a systemic inflammatory disorder with fever, arthritis, and rash.[1] Although the etiology is not known, some viral (rubella, echovirus, Epstein-Barr, cytomegalovirus) and bacterial (Yersinia enterocolitica, Mycoplasma pneumoniae) factors have been accused.[2] It is difficult to diagnose and can be diagnosed by excluding other causes, such as malignancy, collagen tissue disease, and infection. It is very difficult to distinguish from bacterial infections, especially since it is accompanied by fever and rashes, elevated C-reactive protein (CRP), erythrocyte sedimentation rate, and leukocytosis.Öğe Regional Variations İn Psoriatic Arthritis: İnsights From A Nationwide Multicenter Analysis İn Türkiye(Turkish League Against Rheumatism, 2024) Kılıç, Erkan; Kılıç, Gamze; Tekeoğlu, İbrahim; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Ecesoy, HilalObjectives: The study aimed to investigate and compare clinical features, disease activity, and the overall disease burden among psoriatic arthritis (PsA) patients across seven distinct geographic regions in T & uuml;rkiye. Patients and methods: A multicenter cross-sectional study involving 1,134 PsA patients from 25 referral centers across seven regions was conducted. Demographic and clinical characteristics, comorbidities, joint involvement, extra-articular manifestations, and disease activity measures were evaluated across regions. Results: A total of 1134 PsA patients from seven different geographic regions in T & uuml;rkiye participated in this study. The highest number of participants was from the Marmara region (n=409), with subsequent representation from Central Anatolia (n=370), Aegean (n=139), Mediterranean (n=60), Black Sea (n=60), Eastern Anatolia (n=60), and Southeastern Anatolia (n=36) regions. There were significant variations in demographic profile, including age, body mass index, age of disease onset, educational status, comorbidities, and family history of both psoriasis and PsA. Clinical features, such as enthesitis, dactylitis, uveitis, and joint involvement, demonstrated significant variation across regions. Additionally, disease activity measures, including pain, patient and physician global assessments, acute phase reactants, disease activity indices, quality of life, and functional status, displayed considerable regional differences. Conclusion: This nationwide study revealed substantial regional diversity in demographic data, clinical characteristics, disease activity, and quality of life among PsA patients in T & uuml;rkiye. These findings stress the need to customize treatment approaches to address regional needs and to conduct further research to uncover reasons for disparities. It is crucial to enhance region-specific approaches to improve patient care and outcomes for PsA.Öğe The relationship between fibromyalgianess and clinical features, disease activity in patients with systemic lupus erythematosus(Wiley, 2025) Varman, Büşra; Parlak, Selman; Ecesoy, HilalIntroduction: Fibromyalgia (FM) is a chronic syndrome characterised by widespread pain, fatigue, and symptoms such as sleep disturbances, cognitive impairment, and mood disorders. FM prevalence is notably higher among systemic lupus erythematosus (SLE) patients compared with the general population, often leading to diagnostic challenges. Misinterpreting FM as SLE activity can result in overtreatment. This study aimed to evaluate fibromyalgianess and its relationship with the clinical and immunological characteristics of SLE patients using comprehensive scoring methods for better diagnostic accuracy. Materials and Methods: This cross-sectional study included 50 SLE patients meeting the 2019 EULAR/ACR classification criteria. Patients with coexisting autoimmune diseases or severe systemic conditions were excluded. Clinical data, SLEDAI scores, and fibromyalgianess severity were assessed using the Polysymptomatic Distress Scale (PSDS). Patients were categorised into groups based on fibromyalgia diagnostic criteria: widespread pain and SLE-FM. Statistical analysis was performed using SPSS, with p < 0.05 considered significant. Results: Among 50 patients (45 female, 5 male; mean age 42.04 +/- 12.5), 24% had fibromyalgianess, and 18% experienced widespread pain. Female patients exhibited significantly higher PSDS scores (p < 0.05). While NSAID use was associated with increased PSDS scores (p < 0.001), no significant relationship was found between fibromyalgianess and SLEDAI scores or organ involvement. Conclusion: Fibromyalgianess in SLE patients primarily reflects heightened pain sensitivity and symptom severity rather than disease activity. Incorporating fibromyalgianess assessment into routine SLE management may prevent diagnostic and therapeutic pitfalls and improve treatment outcomes. Multidisciplinary approaches, including pharmacological and non-pharmacological strategies, are essential for effective care.
