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    Does pregabalin affect renal functions and plasma electrolytes?
    (Wiley, 2023) Günay, Ahmet Can; Görmüş, Z. Işık Solak; Günay, Merve Akgül; Koca, Raviye Özen; Özdengül, Faik
    Aim: It is known that the half-life of pregabalin increases with age. This may be related to the decline in kidney function with age. In this study, it was aimed to investigate the neurotoxicity and renal toxicity that pregabalin may cause. Materials and Methods: 100 patients followed up in the Department of Neurology between 2019-2020 were included for the study.It was planned to scan the hospital files of the adult patient group using pregabalin. The data obtained as a result of possible changes in serum electrolyte levels and kidney functions of patients with pregabalin indication were evaluated. Peripheral blood urea, uric acid, creatinine, serum electrolyte levels of the patients were determined and glomerular filtration rate (GFR) was analyzed twice, in six months for possible changes in kidney functions. Results: Arithmetic mean values and changes were examined in patients who were measured twice in a six-month period. The effect of pregabalin use on urea and uric acid values, which are markers of renal function, was found to be statistically significant (p<0.05). There was no statistically significant effect on GFR, creatinine, Na+, Cl–, K+, Ca+2, Mg+2 and P+3 parameters (p>0.05). Conclusion: This study may be useful to investigate the effects of pregabalin on other organs. The data obtained may contribute to the provision of information that may be useful to drug research and development institutions and to increase drug safety.