Yazar "Kocabas, Rahim" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Current compherensive approach to Covid-19
    (Duvar Kitapevi, 1/06/2022) Koksoy, Hale; Rağbetli, Murat Çetin; Alp, Harun; Ecesoy, Hilal; Basaran, Aynur; Kaya, Aysenur; Sahin, Ali; Bekci, Taha Tahir; Yesildag, Ahmet; Ecesoy, Volkan; Kocabas, Rahim; Karaburgu, Sülbiye; Ay, Mehmet Emre; Dulger, Ozlem; Osmanoglu, Omer Usame; Serin, Aliye Nigar; Ragbetli, Cennet; Kose, Fulya; Atik, Dilek; Kılıc, Nuray; Mustu, Mehmet; Alkan, Gulsum; Arıcı, Hasan; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, Hale
    This book, prepared by our Karamanoglu Mehmetbey and other faculty members by adding their current experiences during the pandemic process, is one of the leading scientific publications about the COVID-19 pandemic.
  • Küçük Resim
    Öğe
    Current multidisciplinary approach to diabetes mellitus occurrence mechanism
    (Nobel Tıp Bookstores, 30/09/2023) Rağbetli, Murat Çetin; Kaya, Aysenur; Keskin, Seda; Kıran, Tugba Raika; Karabulut Bay, Aysun; Unal, Mustafa; Uguz, A. Cihangir; Kocaman, Süheyla; Dasdelen, Dervis; Koksoy, Hale; Kocabas, Rahim; Ecesoy, Volkan; Arıcı, Hasan; Osmanoglu, Omer Usame; Irgat İncedal, Serap; Gumus, Hale Hatice; Alp, Harun; Rağbetli, Murat Çetin; Koksoy, Hale
    This book aims to provide a current and comprehensive perspective on Diabetes mellitus, a valuable subject in the field of basic sciences. Diabetes mellitus is a chronic disease that affects millions of people worldwide and has become an increasingly serious health problem. This book examines the underlying mechanisms and causes of diabetes using the disciplines of basic sciences. The content of the book begins with fundamental information such as the definition, classification, histopathological mechanisms, and epidemiology of diabetes. It also includes interesting sections on current technologies and the use of artificial intelligence in the field of diabetes. Additionally, the book extensively discusses how genetic predisposition, environmental factors, and lifestyle choices affect the risk of diabetes. This comprehensive evaluation of diabetes from the perspective of basic sciences provides important insights into the development and progression of the disease.
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    Öğe
    The Effect of Dexmedetomidine on Oxidative Balance in Lung, Liver and Heart: Rat Sepsis Model
    (2023) Ulukaya, Sinan Oğuzhan; Kocabas, Rahim; Cihan, Eyüp Fatih; Yosunklaya, Alper
    Aim: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Early intervention in sepsis is vital and research on the subject continues. Having sedative, analgesic, and anxiolytic properties, Dexmedetomidine (DEX) is a potent lipophilic ?2 adrenoceptor agonist with imidazole structure. In recent years, there has been an increasing number of studies on the organ protective effects of DEX. Unlike other studies, in this project proposal, it was aimed to investigate the effect of DEX applied in different periods of sepsis on the oxidative stress index in the lungs, liver and heart. Material and methods: The study was approved by the Necmettin Erbakan University Experimental Animals Ethics Committee (2020 – 017). In the study, 50 female wistar albino rats were used as experimental animals. Animals were divided into five groups: 1st group: SHAM (n:10), 2nd group: SEPSIS (n:10), 3rd group: DEX (PreDEX, n:10) applied 30 minutes before cecal ligation puncture (CLP) procedure, group 4: DEX administered 12 hours after CLP (Post12DEX, n:10), group 5: DEX administered 24 hours after CLP (Post24DEX, n:10). Results: In liver and heart tissues, the decrease in total antioxidant status (TAS) levels in the SEPSIS group was statistically significant compared to the Post12DEX (p
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    Öğe
    Effect of Vitamin D on YKL-40: Rat Hypercholesterolemia Model
    (Korean Soc Cardiology, 2023) Kocabas, Rahim
    Background and Objectives: YKL-40 is considered to be associated with cardiovascular disease (CVD). In this study, the effect of serum 25(OH) vitamin D [25(OH)VitD] differences between groups on YKL-40 was evaluated on a hypercholesterolemia rat model.Methods: Thirty-two male rats (wistar albino) were equally divided into 4 groups. The first group was the control group; the second group was high-cholesterol (H-CH) adequate vitamin D (VitD) group (H-AdeVD). The third group was the H-CH deficient VitD group (H-DefVD), and the last group was designed with the H-CH supplement VitD (H-SupVD). The feeding process consisted of 2 stages. At the first stage (5 months), the H-DefVD group was fed on VitD deficient chow, while the other groups (control, H-AdeVD, H-SupVD) were fed on standard chow. At the second stage (3 months), the H-AdeVD and the H-SupVD groups were fed on the H-CH chow, whereas the H-DefVD group was fed on the H-CH-VitD deficient chow. Moreover, the H-SupVD group was given 100 IU/kg/day VitD along with the H-CH chow. Results: Compared with the control group, interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and YKL-40 values in the H-DefVD groups increased significantly (p<0.001, p<0.001, p=0.009, p=0.005; sequentially).Conclusion: It can be concluded that VitD can suppress the YKL-40, thus, it will prevent CVD development in rat. Therefore, further clinical studies related with human will reveal the effect of VitD and YKL-40 on CVD development.
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    Öğe
    PLAZMA APELİN DÜZEYİ VE PRE-EKLAMPSİ VAKALARI ARASINDAKİ BAĞLANTININ ARAŞTIRILMASI
    (2023) Karabulut, Ercan; Akoz, Mehmet; Bayman, Melike Geyik; Kocabas, Rahim; Zeytin, Fatih
    Amaç Gebelikte gelişen ve multi-sistemik bir hastalık olan pre-eklampsi, yılda en az 42.000 anne ölümüne sebep olan bir patolojidir. Pre-eklampsi patofizyolojisine ilişkin teoriler, temel olarak yüzeysel plasentasyon ile ilişkili olduğu düşünülen maternal-fetal immün malperfüzyona dayanmakta ve pre-eklampsinin nedeni ise henüz tam olarak aydınlatılamamıştır. Apelin, kan basıncı regülasyonu ve vasküler fonksiyonları etkileyen, ayrıca çeşitli fizyolojik görevleri olan bir peptittir. Bu çalışmada, pre-eklampsi gelişiminde apelin-13’ün rolünün olup olmadığını değerlendirmek amacıyla normal ve erken başlangıçlı pre-eklampsili gebelerde, plazma apelin-13 seviyeleri çalışıldı. Gereç ve Yöntem Bu vaka kontrol prospektif çalışma, Kadın Hastalıkları ve Doğum Servisine başvuran gebelerin içerisinde toplam 60 gebe çalışmaya dahil edildi. Projedeki gruplar sağlıklı gebe kontrol (n:30) ve erken başlangıçlı pre-eklampsi gebe (n:30) olarak dizayn edildi. Erken başlangıçlı pre-eklampsi grubu 30. haftada pre-eklampsi tanısı konan erken başlangıçlı pre-eklampsi gebelerden oluşmakta idi. Katılımcılardan 30. hafta alınan kan örneklerinden trombosit, serum albümin, ALT, AST, üre, kreatinin ve plazma apelin-13 değerleri ölçüldü. Bulgular Sağlıklı gebe kontrollere göre, erken başlangıçlı pre-eklampsi gebelerdeki trombosit, serum albümin, seviyelerindeki azalma ve ALT, AST, üre ve kreatinin parametrelerindeki artma, istatiksel değerlendirme açısından anlamlı bulundu (p=0,011; p=0,001; p=0,006; p=0,05; p=0,001; p=0,003; sırasıyla). Plazma apelin-13 değeri sağlıklı ve erken başlangıçlı pre-eklampsi gebeler arasında karşılaştırıldığında anlamlı bir fark bulunmadı. Sonuç 30. haftadan sonra gelişen erken başlangıçlı pre-eklampsinin teşhisinde Apelin-13’ün tanısal değeri bulunmamaktadır.
  • Küçük Resim
    Öğe
    Stem cell, experimental animals and cell culture studies in diabetes
    (Nobel Tıp Bookstores, 30/09/2023) Koksoy, Hale; Kocabas, Rahim; Alp, Harun; Koksoy, Hale; Rağbetli, Murat Çetin
    This book aims to provide a current and comprehensive perspective on Diabetes mellitus, a valuable subject in the field of basic sciences. Diabetes mellitus is a chronic disease that affects millions of people worldwide and has become an increasingly serious health problem. This book examines the underlying mechanisms and causes of diabetes using the disciplines of basic sciences. The content of the book begins with fundamental information such as the definition, classification, histopathological mechanisms, and epidemiology of diabetes. It also includes interesting sections on current technologies and the use of artificial intelligence in the field of diabetes. Additionally, the book extensively discusses how genetic predisposition, environmental factors, and lifestyle choices affect the risk of diabetes. This comprehensive evaluation of diabetes from the perspective of basic sciences provides important insights into the development and progression of the disease.