Cytogenetic and Oxidative Status of Cultured Lymphocytes after Exposure to Extracts from Rhizopogon Mushrooms (Agaricomycetes) In Vitro

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dc.contributor.authorEmsen, Bugrahan
dc.contributor.authorTurel, Asuman
dc.contributor.authorKaya, Abdullah
dc.contributor.authorAslan, Ali
dc.contributor.authorEngin, Tubanur
dc.date.accessioned2025-01-12T17:20:40Z
dc.date.available2025-01-12T17:20:40Z
dc.date.issued2021
dc.departmentKaramanoğlu Mehmetbey Üniversitesi
dc.description.abstractIn this study, acetone and water extracts obtained from edible mushrooms, Rhizopogon luteolus Fr. and Rh. roseolus (Corda) Th. Fr., containing important bioactive components were used. Total antioxidant capacity (TAC) and total oxidative stress (TOS) levels were examined on human peripheral lymphocyte culture treated with the respective extracts. Levels of genetic damage and cytotoxic effects of the respective extracts on lymphocytes were also tested. In general, when TAC levels of the extracts on cells were examined, a concentration-dependent increase was observed; a negative correlation was found between TOS data and concentration. Genotoxicity tests (chromosome aberration and micronucleus analysis) revealed that the concentrations of the extract applications did not significantly (P > 0.05) change genotoxicity on human peripheral lymphocyte culture compared to the negative control. Considering all of the results obtained, it was determined that applications of Rh. luteolus and Rh. roseolus extracts, especially at concentrations of 50 and 100 mg/L, increased the TAC value of lymphocytes, which play an important role in the human inunune system, without causing genetic or oxidative stress.
dc.description.sponsorshipKaramanoglu Mehmetbey University Scientific Research Projects Commission [06-YL-19]
dc.description.sponsorshipThis work was supported by the Karamanoglu Mehmetbey University Scientific Research Projects Commission (Project No. 06-YL-19).
dc.identifier.issn1521-9437
dc.identifier.issn1940-4344
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/11492/10462
dc.identifier.volume23
dc.identifier.wosWOS:000637192500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Sceince
dc.language.isoen
dc.publisherBegell House Inc
dc.relation.ispartofInternational Journal of Medicinal Mushrooms
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20250111
dc.subjectRhizopogon mushrooms
dc.subjectantioxidant
dc.subjectgenotoxicity
dc.subjectfungus
dc.subjectoxidative stress
dc.subjectcytotoxicity
dc.subjectmedicinal mushrooms
dc.titleCytogenetic and Oxidative Status of Cultured Lymphocytes after Exposure to Extracts from Rhizopogon Mushrooms (Agaricomycetes) In Vitro
dc.typeArticle

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