Investigation of the relationship between fatigue with vitamin D, disease stage, anxiety and physical activity level in patients with Parkinson's disease

Aims: The aim of this study was to investigate the relationship between fatigue severity with vitamin D level, disease stage, anxiety and, physical activity level in patients with Parkinson’s disease (PD). Methods: This study included 66 (male=38, female=28) individuals diagnosed with PD. Fatigue severity was evaluated by the fatique severity scale, vitamin D level by blood test results, anxiety by the Beck Anxiety Inventory (BAI), disease stage by Hoehn- Yahr (HY) staging, and physical activity level by the International Physical Activity Questionnaire (IPAQ-short form). Results: The study included 66 (male=38, female=28) individuals diagnosed with PD. Fatigue severity was assessed by the fatique severity scale, vitamin D level by blood test results, anxiety by the BAI, disease stage by HY staging, and physical activity level by the IPAQ-short form. In addition, a significant correlation was found between fatigue severity with vitamin D level, anxiety, disease stage, and physical activity level in men, women, and all patients (p<0.05). Conclusion: In Parkinson’s patients, fatigue may be related to disease stage, anxiety, physical activity level, and vitamin D level. We suggest that these results should be taken into consideration in fatigue coping strategies for patients with PD.