Preparation of pillar[5]arene functionalized silica gel hybrid material: investigation of biological (antimicrobial, antioxidant and anti-cancer) properties

Basit Öğe Kaydı
dc.authoridBilgiç, Ali/0000-0002-7055-0847
dc.authoridUlusu, Funda/0000-0002-0321-2602
dc.contributor.authorUlusu, Funda
dc.contributor.authorBilgiç, Ali
dc.date.accessioned2025-01-12T17:19:38Z
dc.date.available2025-01-12T17:19:38Z
dc.date.issued2024
dc.departmentKMÜ, Teknik Bilimler Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümü
dc.departmentKMÜ, Teknik Bilimler Meslek Yüksekokulu, Mülkiyeti Koruma ve Güvenlik Bölümü
dc.description.abstractThe current study presents the incorporation of APTMS and pillar[5]arene groups into the molecular structures of silica gel materials whose structures were elucidated by characterization techniques such as SEM, FT-IR, and TGA. Comprehensive biological applications of these derivatives such as antibacterial, antioxidant and anticancer were evaluated for the first time in the study. The data show the effectiveness of the silica gel materials, especially Si-APTMS-pillar[5]arene, in the fight against pathogenic microorganisms with its strong antibacterial properties against both gram-negative and gram-positive bacteria. They also reveal that these materials have significant antioxidant pharmacological potential with their significant DPPH scavenging activities. The results obtained from cytotoxicity studies highlight their potential as anticancer agents, with the synthesized silica gel materials, especially Si-APTMS-pillar[5]arene materials, having a greater inhibitory effect on cancer cell lines compared to healthy cell lines over a 24 h period. This comprehensive research illustrates the promising versatility of the silica gel materials in a variety of biomedical and environmental applications, including cancer therapy, antimicrobial strategies, and free radical neutralization. APTMS and pillar[5]arene groups have been successfully added to the molecular structures of silica gel materials.The surface of Si, Si-APTMS and [5] materials was characterized by various techniques such as FT-IR, TGA, SEM.The comprehensive biological applications of Si, Si-APTMS and [5], including antibacterial, antioxidant and anti-cancer studies, were realised for the first time in this study.Remarkable anti-cancer mechanisms of [5] supramolecule on HT-29 cell line were suggested.Silica gel materials have efficacy in combating pathogenic microorganisms with strong antibacterial properties and pharmacological potential as important antioxidative materials with pronounced DPPH scavenging activities.
dc.description.sponsorshipWe sincerely thank the administrations of Karamanolu Mehmetbey University, Department of Chemistry, Department of Bioengineering, and Vocational School of Technical Sciences, for providing the necessary facilities to produce this product.
dc.identifier.citationUlusu, F., & Bilgic, A. (2024). Preparation of pillar[5]arene functionalized silica gel hybrid material: investigation of biological (antimicrobial, antioxidant and anti-cancer) properties. Journal of Sol-Gel Science and Technology, 1–13. https://doi.org/10.1007/s10971-024-06580-w
dc.identifier.doi10.1007/s10971-024-06580-w
dc.identifier.issn0928-0707
dc.identifier.issn1573-4846
dc.identifier.scopus2-s2.0-85206816632
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10971-024-06580-w
dc.identifier.urihttps://hdl.handle.net/11492/10127
dc.identifier.wosWOS:001334553500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.institutionauthorUlusu, Funda
dc.institutionauthorBilgiç, Ali
dc.institutionauthoridBilgiç, Ali/0000-0002-7055-0847
dc.institutionauthoridUlusu, Funda/0000-0002-0321-2602
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Sol-Gel Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSilica gel
dc.subjectPillar[5]arene
dc.subjectImmobilization
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectAnti-cancer
dc.titlePreparation of pillar[5]arene functionalized silica gel hybrid material: investigation of biological (antimicrobial, antioxidant and anti-cancer) properties
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Bitkisel ve Hayvansal Üretim Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Teknik Bilimler MYO, Mülkiyeti Koruma ve Güvenlik Bölümü,Makale Koleksiyonu