The Effect of Dexmedetomidine on Oxidative Balance in Lung, Liver and Heart: Rat Sepsis Model

Basit Öğe Kaydı
dc.contributor.authorUlukaya, Sinan Oğuzhan
dc.contributor.authorKocabas, Rahim
dc.contributor.authorCihan, Eyüp Fatih
dc.contributor.authorYosunklaya, Alper
dc.date.accessioned2024-01-22T12:23:11Z
dc.date.available2024-01-22T12:23:11Z
dc.date.issued2023
dc.departmentKMÜen_US
dc.description.abstractAim: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Early intervention in sepsis is vital and research on the subject continues. Having sedative, analgesic, and anxiolytic properties, Dexmedetomidine (DEX) is a potent lipophilic ?2 adrenoceptor agonist with imidazole structure. In recent years, there has been an increasing number of studies on the organ protective effects of DEX. Unlike other studies, in this project proposal, it was aimed to investigate the effect of DEX applied in different periods of sepsis on the oxidative stress index in the lungs, liver and heart. Material and methods: The study was approved by the Necmettin Erbakan University Experimental Animals Ethics Committee (2020 – 017). In the study, 50 female wistar albino rats were used as experimental animals. Animals were divided into five groups: 1st group: SHAM (n:10), 2nd group: SEPSIS (n:10), 3rd group: DEX (PreDEX, n:10) applied 30 minutes before cecal ligation puncture (CLP) procedure, group 4: DEX administered 12 hours after CLP (Post12DEX, n:10), group 5: DEX administered 24 hours after CLP (Post24DEX, n:10). Results: In liver and heart tissues, the decrease in total antioxidant status (TAS) levels in the SEPSIS group was statistically significant compared to the Post12DEX (pen_US
dc.identifier.doi10.54005/geneltip.1224337
dc.identifier.endpage99en_US
dc.identifier.issn2602-3741
dc.identifier.issue1en_US
dc.identifier.startpage95en_US
dc.identifier.trdizinid1162282
dc.identifier.urihttps://doi.org/10.54005/geneltip.1224337
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1162282
dc.identifier.urihttps://hdl.handle.net/11492/8305
dc.identifier.volume33en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofGenel Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzkmusnmz
dc.titleThe Effect of Dexmedetomidine on Oxidative Balance in Lung, Liver and Heart: Rat Sepsis Modelen_US
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu