Responses of Helper T Cell Subsets at Diagnosis and After Discharge in Patients with Non-Severe COVID-19: A Prospective Observational Study

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dc.contributor.authorKaraselek, Mehmet Ali
dc.contributor.authorDuran, Tuğce
dc.contributor.authorKüççüktürk, Serkan
dc.contributor.authorVatansev, Hülya
dc.date.accessioned2025-01-12T17:20:08Z
dc.date.available2025-01-12T17:20:08Z
dc.date.issued2024
dc.departmentKMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus Disease 2019 (COVID-19), elicits a strong immune response similar to that seen in other viral infections. The predominant cell type in this immune response also influences the disease prognosis. This study, conducted between 2022 and May 2023, aimed to evaluate the transcription factors and cytokine expressions of Th (helper T) cell subsets at the time of diagnosis and after discharge in patients with nonsevere COVID-19. Materials and Methods: Forty-eight patients with non -severe COVID-19 were included in the study. Transcription factor and cytokine expressions of Th cell subsets were evaluated using the quantitative polymerase chain reaction (qPCR) method, and the results were compared at the time of diagnosis and after discharge. Results: It was determined that the cytokines and transcription factors of T helper 1 (Th1) cells (T -box expressed in T cells [T -bet], 2.71 -fold, p<0.001; Interferon -gamma [IFN-gamma], 1.42fold, p=0.010) and T helper 17 (Th17) cells (RAR-related orphan receptor gamma [ROR gamma t], 1.06 -fold, p=0.946; Interleukin-22 [IL -22], 1.01 -fold, p=0.599) decreased, whereas the expression of T helper 2 (Th2) cells (GATA binding protein 3 [GATA3], 2.56 -fold, p<0.001; Interleukin-4 [IL -4], 1.34 -fold, p=0.012; Interleukin-5 [IL -5], 1.02 -fold, p=0.649; Interleukin-13 [IL -13], 2.06 -fold, p=0.0119) and regulatory T (Treg) cells (Forkhead box P3 [FoxP3], 3.56 -fold, p<0.001; Transforming growth factor -beta [TGF-beta], 1.03 -fold, p=0.670; Interleukin-10 [IL -10], 1.40 -fold, p=0.010) increased. Conclusion: Our study in non -severe COVID-19 patients demonstrated significant changes in the transcription factor and cytokine expressions of Th cell subsets at the time of diagnosis compared to discharge. We think that even if the patients do not exhibit severe clinical and laboratory findings, Th cell immune responses may be strong, warranting careful consideration.
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Unit [201218010]
dc.description.sponsorshipThe study was supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit with project number 201218010.
dc.identifier.citationKaraselek, M. A. (2024). Responses of Helper T Cell Subsets at Diagnosis and After Discharge in Patients with Non-Severe COVID-19: A Prospective Observational Study. Journal of Clinical Practice and Research. https://doi.org/10.14744/cpr.2024.14622
dc.identifier.doi10.14744/cpr.2024.14622
dc.identifier.endpage75
dc.identifier.issn2980-2156
dc.identifier.issue1
dc.identifier.startpage67
dc.identifier.trdizinid1281035
dc.identifier.urihttps://doi.org/10.14744/cpr.2024.14622
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1281035
dc.identifier.urihttps://hdl.handle.net/11492/10328
dc.identifier.volume46
dc.identifier.wosWOS:001164483700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKüççüktürk, Serkan
dc.institutionauthoridKüççüktürk, Serkan/0000-0001-8445-666X
dc.language.isoen
dc.publisherErciyes Univ Sch Medicine
dc.relation.ispartofJournal of Clinical Practice and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectTh1
dc.subjectTh2
dc.subjectTh17
dc.subjectTreg
dc.titleResponses of Helper T Cell Subsets at Diagnosis and After Discharge in Patients with Non-Severe COVID-19: A Prospective Observational Study
dc.typeArticle

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