Antioxidant and genotoxic effects of aqueous and methanol extracts from two edible mushrooms from turkey in human peripheral lymphocytes

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dc.authorid0000-0002-9636-2596en_US
dc.authorid0000-0002-6423-6085en_US
dc.contributor.authorEmsen, Buğrahan
dc.contributor.authorGüven, Büşranur
dc.contributor.authorUzun, Yasin
dc.contributor.authorKaya, Abdullah
dc.date.accessioned2020-06-04T08:07:10Z
dc.date.available2020-06-04T08:07:10Z
dc.date.issued2020en_US
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000520021000006 PubMed ID: 32479004en_US
dc.description.abstractThis study reported the genetic and oxidative effects of aqueous and methanol extracts from two edible mushrooms, Lepista nuda (Bull.) Cooke and Pleurotus ostreatus (Jacq.) P. Kummer, in cultured human lymphocytes. Chromosome aberration (CA) and micronucleus (MN) assays were used for genotoxic influences estimation. In addition, the changes of total antioxidant capacity (TAC) and total oxidative stress (TOS) in the cells were monitored. The fungal extracts at all applied concentrations did not indicate significant differences (p > 0.05) in CA and MN analyses. Furthermore, while the treatments with maximum concentration of aqueous extract of L. nuda statistically (p < 0.05) increased TAC especially, TOS levels in the cells were reduced by them in comparison with negative control. Based on TAC analysis, low IC50 values belonging to aqueous (5.43 mg/L) and methanol (10.88 mg/L) extracts of L. nuda were remarkable. Our data demonstrated that the extracts obtained from P. ostreatus and especially L. nuda can be a new resource for therapeutics with their nonmutagenic and antioxidant features.en_US
dc.identifier.citationEmsen, B., Guven, B., Uzun, Y., & Kaya, A. (2020). Antioxidant and Genotoxic Effects of Aqueous and Methanol Extracts from Two Edible Mushrooms from Turkey in Human Peripheral Lymphocytes. International Journal of Medicinal Mushrooms, 22, 2, 161-170.en_US
dc.identifier.doi10.1615/IntJMedMushrooms.2020033845
dc.identifier.endpage170en_US
dc.identifier.issn1521-9437
dc.identifier.issn1940-4344
dc.identifier.issue2en_US
dc.identifier.pmid32479004
dc.identifier.scopus2-s2.0-85082082866
dc.identifier.scopusqualityQ3
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1615/IntJMedMushrooms.2020033845
dc.identifier.urihttps://hdl.handle.net/11492/3494
dc.identifier.volume22en_US
dc.identifier.wosWOS:000520021000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEmsen, Buğrahan
dc.institutionauthorUzun, Yasin
dc.language.isoen
dc.publisherBegell House Incen_US
dc.relation.journalInternational Journal of Medicinal Mushroomsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLepista Nudaen_US
dc.subjectPleurotus Ostreatusen_US
dc.subjectAntioxidativeen_US
dc.subjectChromosome Aberrationen_US
dc.subjectGenotoxicityen_US
dc.subjectMicronucleusen_US
dc.subjectMedicinal Mushroomsen_US
dc.titleAntioxidant and genotoxic effects of aqueous and methanol extracts from two edible mushrooms from turkey in human peripheral lymphocytesen_US
dc.typeArticle

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