Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats

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dc.authorid0000-0002-6422-1203en_US
dc.contributor.authorBabacanoğlu, C.
dc.contributor.authorYıldırım, N.
dc.contributor.authorSadi, Gökhan
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorAkar, Fatma
dc.date.accessioned2019-12-06T21:17:41Z
dc.date.available2019-12-06T21:17:41Z
dc.date.issued2013
dc.departmentKMÜ, Kamil Özdağ Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionWOS:000325231700019en_US
dc.descriptionPubMed:23872130en_US
dc.description.abstractDietary intake of fructose and sucrose can cause development of metabolic and cardiovascular disorders. The consequences of high-fructose corn syrup (HFCS), a commonly consumed form of fructose and glucose, have poorly been examined. Therefore, in this study, we investigated whether HFCS intake (10% and 20% beverages for 12 weeks) impacts vascular reactivity to insulin and endothelin-1 in conjunction with insulin receptor substrate-1(IRS-1), endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) mRNA/proteins levels in aorta of rats. At challenge, we tested the effectiveness of resveratrol (2830 mg/kg body weight/day) on outcomes of HFCS feeding. HFCS (20%) diet feeding increased plasma triglyceride, VLDL, cholesterol, insulin and glucose levels, but not body weights of rats. Impaired nitric oxide-mediated relaxation to insulin (10(-9) to 3 x 10(-6) M), and enhanced contraction to endothelin-1 (10(-11) to 10(-8) M) were associated with decreased expression of IRS-1 and eNOS mRNA and protein, but increased expression of iNOS, in aortas of rats fed with HFCS. Resveratrol supplementation restored many features of HFCS-induced disturbances, probably by regulating eNOS and iNOS production. In conclusion, dietary HFCS causes vascular insulin resistance and endothelial dysfunction through attenuating IRS-1 and eNOS expressions as well as increasing iNOS in rats. Resveratrol has capability to recover HFCS-induced disturbances. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipGazi UniversityGazi University [BAP 02/2010-26, 02/2012-48]en_US
dc.description.sponsorshipThis study was supported by Grants from Gazi University Research Fund (BAP 02/2010-26 and 02/2012-48).en_US
dc.identifier.citationBabacanoğlu, C., Yıldırım, N., Sadi, G., Pektaş, M. B., Akar, F. (2013). Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats. Food and Chemical Toxicology, Volume 60, October 2013, Pages 160-167.
dc.identifier.doi10.1016/j.fct.2013.07.026
dc.identifier.endpage167en_US
dc.identifier.issn0278-6915
dc.identifier.pmid23872130
dc.identifier.scopus2-s2.0-84882574019
dc.identifier.scopusqualityQ1
dc.identifier.startpage160en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2013.07.026
dc.identifier.urihttps://hdl.handle.net/11492/3169
dc.identifier.volume60en_US
dc.identifier.wosWOS:000325231700019
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSadi, Gökhan
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.journalFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-Fructose Corn Syrupen_US
dc.subjectResveratrolen_US
dc.subjectVascular Insulin Resistanceen_US
dc.subjectEndothelinen_US
dc.subjectIRS-1en_US
dc.subjecteNOSen_US
dc.titleResveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in ratsen_US
dc.typeArticle

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