Salivary levels of supar, hıf-1α and tnf-α in different grades of stage ııı periodontitis

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dc.contributor.authorTaşdemir, İsmail
dc.contributor.authorÖzgören, Özgür
dc.contributor.authorYılmaz, Huriye Erbak
dc.contributor.authorKartal, Emine
dc.contributor.authorAltunyaprak, Şeyma
dc.contributor.authorSağlam, Mehmet
dc.date.accessioned2025-07-31T07:47:28Z
dc.date.available2025-07-31T07:47:28Z
dc.date.issued2025
dc.departmentKMÜ, Ahmet Keleşoğlu Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.departmentKMÜ, Ahmet Keleşoğlu Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.departmentKMÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Dişçilik Hizmetleri Bölümü
dc.description.abstractThe aim of the study is to evaluate saliva levels of Soluble urokinase plasminogen activator receptor (suPAR), Hypoxia-inducible factor-1 alpha (HIF-1α) and tumor necrosis factor-alpha (TNF-α) in stage III grade A, grade B, grade C periodontitis and periodontal health and to understand the roles of these molecules in periodontal inflammation process and also to compare the three biomarkers' discriminative efficacy in periodontal disease. Methods: A total of 80 individuals, 20 with stage III grade A periodontitis (group A), 20 with stage III grade B periodontitis (group B), 20 with stage III grade C periodontitis (group C) and 20 with healthy periodontium (group H) were recruited for this study. Full-mouth clinical periodontal measurements were recorded in periodontal charts. Whole saliva samples were collected to determine the levels of suPAR, HIF-1α and TNF-α in study groups using enzyme-linked immunosorbent assay (ELISA) method. Results: The saliva concentration of suPAR, HIF-1α, and TNF α was significantly higher in group A, group B, and group C compared with group H (p <.05). Additionally, salivary suPAR concentration was significantly higher in group C than in groups A and B (p <.05). Positive statistically significant correlations were observed between three biomarkers and all clinical parameters (p <.05). Conclusions: Increased levels of saliva suPAR, HIF-1α, and TNF α suggest that these molecules may play a role in periodontitis. In addition, the higher salivary suPAR levels in grade C periodontitis compared to other grades suggest that suPAR may be one of the potential molecules that can be used to predict disease progression and periodontal disease classification. Trial registration: Before starting the study, the study plan was uploaded to clinicaltrials.gov.tr ​​and an identification number was obtained (Date: 21.05.2024, İdentification number: NCT06430450).
dc.identifier.doi10.1186/s12903-025-06155-3
dc.identifier.issn14726831
dc.identifier.issue1
dc.identifier.pmid40405145
dc.identifier.pmid40405145
dc.identifier.startpage760
dc.identifier.urihttps://www.doi.org/10.1186/s12903-025-06155-3
dc.identifier.urihttps://hdl.handle.net/11492/10877
dc.identifier.volume25
dc.identifier.wosWOS:001493927700004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTaşdemir, İsmail
dc.institutionauthorÖzgören, Özgür
dc.institutionauthorAltunyaprak, Şeyma
dc.institutionauthoridTaşdemir, İsmail/0000-0003-0110-1412
dc.institutionauthoridÖzgören, Özgür/0009-0008-2175-1790
dc.institutionauthoridAltunyaprak, Şeyma/0000-0003-1373-9034
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.relation.ispartofBMC Oral Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHypoxia-İnducible Factor-1α
dc.subjectPeriodontitis
dc.subjectSaliva
dc.subjectSupar
dc.subjectTumor Necrosis Factor Alpha
dc.titleSalivary levels of supar, hıf-1α and tnf-α in different grades of stage ııı periodontitis
dc.typeArticle

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