A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions

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dc.authoridÜlger, Taha Gökmen/0000-0002-7751-9789
dc.authoridAdıgüzel, Emre/0000-0002-9041-8990
dc.contributor.authorAdıgüzel, Emre
dc.contributor.authorÜlger, Taha Gökmen
dc.date.accessioned2025-01-12T17:19:42Z
dc.date.available2025-01-12T17:19:42Z
dc.date.issued2024
dc.departmentKMÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractAstaxanthin is a potent lipid -soluble carotenoid produced by several different freshwater and marine microorganisms, including microalgae, bacteria, fungi, and yeast. The proven therapeutic effects of astaxanthin against different diseases have made this carotenoid popular in the nutraceutical market and among consumers. Recently, astaxanthin is also receiving attention for its effects in the co -adjuvant treatment or prevention of neurological pathologies. In this systematic review, studies evaluating the efficacy of astaxanthin against different neurodegenerative diseases such as Alzheimer 's disease, Parkinson 's disease, multiple sclerosis, cerebrovascular diseases, and spinal cord injury are analyzed. Based on the current literature, astaxanthin shows potential biological activity in both in vitro and in vivo models. In addition, its preventive and therapeutic activities against the above -mentioned diseases have been emphasized in studies with different experimental designs. In contrast, none of the 59 studies reviewed reported any safety concerns or adverse health effects as a result of astaxanthin supplementation. The preventive or therapeutic role of astaxanthin may vary depending on the dosage and route of administration. Although there is a consensus in the literature regarding its effectiveness against the specified diseases, it is important to determine the safe intake levels of synthetic and natural forms and to determine the most effective forms for oral intake.
dc.identifier.citationAdıgüzel, E., & Ülger, T. G. (2024). A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions. European Journal of Pharmacology, 977. https://doi.org/10.1016/j.ejphar.2024.176706
dc.identifier.doi10.1016/j.ejphar.2024.176706
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid38843946
dc.identifier.scopus2-s2.0-85195216944
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2024.176706
dc.identifier.urihttps://hdl.handle.net/11492/10166
dc.identifier.volume977
dc.identifier.wosWOS:001263817500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAdıgüzel, Emre
dc.institutionauthoridAdıgüzel, Emre/0000-0002-9041-8990
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20250111
dc.subjectAstaxanthin
dc.subjectAlzheimer's disease
dc.subjectParkinson's disease
dc.subjectCerebral ischemia-reperfusion
dc.subjectSubarachnoid hemorrhage
dc.subjectSpinal cord injury
dc.titleA marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions
dc.typeReview Article

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