Effect of MIND diet on oxidative stress markers in multiple sclerosis

The aim of this dietary intervention study is to evaluate the effect of the MIND diet on oxidative stress markers and nutritional status in patients with Multiple sclerosis (MS). Methods: The study was conducted on 30 participants aged of 20–45 who were diagnosed with Relapsing-remitting MS. After the initial evaluation, healthy nutrition recommendations were given to the participants through a MIND diet sample menu list for 8 weeks. At the end of the study, all measurements were repeated. Results: The mean score of MIND diet adherence questionnaire and serum total antioxidant status level increased significantly at the end of the eighth week (p < 0.001 and p < 0.05). Although the results were not significant, serum superoxide dismutase, catalase and glutathione peroxidase levels tended to increase. In females, there was a significant decrease in body weight, body mass index, waist circumference and total body bone-free lean mass at the end of the study (p < 0.05). In addition, mean daily protein intake and protein intake per kg increased significantly in males (p = 0.028 for both variables) and dietary fiber intake increased significantly (p = 0.047) in all participants. Conclusion: This study showed that the MIND diet may has positive effects on increasing the defense system against inflammation and oxidative stress.