The potential protective effects of melatonin and omega-3 on the male rat optic nerve exposed to 900?MHz electromagnetic radiation during the prenatal period

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dc.authoridKaya, Ayşenur/0000-0002-3878-0087
dc.authoridAlrafiah, Aziza/0000-0003-0978-5775
dc.contributor.authorTuefekci, Kiymet Kuebra
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorKaya, Aysenur
dc.contributor.authorAlrafiah, Aziza
dc.contributor.authorAltun, Gamze
dc.contributor.authorAktas, Abit
dc.date.accessioned2024-01-22T12:22:18Z
dc.date.available2024-01-22T12:22:18Z
dc.date.issued2023
dc.departmentKMÜen_US
dc.description.abstractBackground: Due to children and adolescents' widespread use of electronic devices, researchers have focused on pre-and early postnatal electromagnetic field (EMF) exposure. However, little is known about the effects of EMF exposure on the optic nerve. The aim of study was to investigate the changes occurring in the optic nerve and the protective effects of melatonin (mel) and omega 3 (?-3) in rats.Methods: Thirty-five pregnant rats were divided into seven groups, Cont, Sham, EMF, EMF + melatonin (EMF + Mel), EMF + ?3, Mel, and ?3. The EMF groups were exposed to 900 megahertz (MHz) EMF daily for two hours during pregnancy. After the experiment, the right optic nerve of each offspring rat was removed and fixed in glutaraldehyde. Thin and semi-thin sections were taken for electron microscopic and stereological analyses. Myelinated axon numbers, myelin sheath thicknesses, and axonal areas were estimated using stereological methods.Results: The groups had no significant differences regarding mean numbers of axons, mean axonal areas, or mean myelin sheath thicknesses (p > 0.05). Histological observations revealed impaired lamellae in the myelin sheath of most axons, and vacuolization was frequently observed between the myelin sheath and axon in the EMF-exposed group. The Mel and ?-3-treated EMF groups exhibited well-preserved myelinated nerve fibers and intact astrocytes and oligodendrocytes.Conclusions: At the ultrastructural level, Mel and ?3 exhibits a neuroprotective effect on the optic nerve exposed to prenatal EMF. The protective effects of these antioxidants on oligodendrocytes, which play an essential role in myelin formation in the central nervous system, now require detailed investigation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Tuerkiye; [119S11]en_US
dc.description.sponsorshipWe would like to thank to Mr. Carl Nino Rossini, who is a native speaker, for language revision of the manuscript. This study was partly supported by a grant from The Scientific and Technological Research Council of Tuerkiye (Sueleyman Kaplan; No. 119S11).en_US
dc.identifier.doi10.1080/00207454.2023.2259078
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid37712630en_US
dc.identifier.pmid37712630
dc.identifier.scopus2-s2.0-85171735700
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/00207454.2023.2259078
dc.identifier.urihttps://hdl.handle.net/11492/7900
dc.identifier.wosWOS:001071071600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzkmusnmz
dc.subjectAxonen_US
dc.subjectmelatoninen_US
dc.subjectomega-3en_US
dc.subjectnucleatoren_US
dc.subjectfractionatoren_US
dc.titleThe potential protective effects of melatonin and omega-3 on the male rat optic nerve exposed to 900?MHz electromagnetic radiation during the prenatal perioden_US
dc.typeArticle

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