A half-natural origin approach for anticancer and antioxidant activities using sporopollenin and pillar[5]arene macroring

Basit Öğe Kaydı
dc.contributor.authorUlusu, Funda
dc.contributor.authorBilgiç, Ali
dc.contributor.authorKursunlu, Ahmed Nuri
dc.date.accessioned2025-03-12T08:28:49Z
dc.date.available2025-03-12T08:28:49Z
dc.date.issued2025
dc.departmentKMÜ, Teknik Bilimler Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümü
dc.departmentKMÜ, Teknik Bilimler Meslek Yüksekokulu, Mülkiyeti Koruma ve Güvenlik Bölümü
dc.description.abstractSporopollenin is a natural biomacromolecule which can be found in the outer wall (exine) of spores or pollens that it can be performed with clever designing in a lot of innovative and scientific areas. In this paper, a novel sporopollenin reformed with a recently synthesized pillar[5]arene molecule were elucidated by FT-IR spectroscopy, TGA and SEM techniques. This study is the first report leading to a comprehensive investigation of the biological applications of a functionalized bio-microcapsule including antioxidant and anticancer properties. Two in vitro assays (DPPH and FRAP) were used to determine the antioxidant activities of sporopollenin and functionalized microcapsules. Furthermore, the anticancer activities of these microcapsules were tested on 2 different cancer cell lines (HT-29 and MCF-7), and a fibroblast cell line (L929) by the Alamar blue assay. Among the samples tested in the antioxidant capacity results, especially Sp-P[5] exhibited higher antioxidant capacity and stood out with IC50: 101.98 f 4.32 mu g/mL in DPPH assay and IC50: 87.97 f 3.14 mu g/mL in FRAP assay. Similar to the antioxidant result, Sp-P[5] bio-microcapsule had greater cell inhibition on HT-29 (IC50: 132.31 f 5.38 mu g/mL), MCF-7 (IC50: 107.30 f 8.28 mu g/mL), and L929 (IC50: 255.80 f 4.91 mu g/mL) cell lines than Sp and Sp-APTMS. The analysis results in the study show promise for the development of sporopollenin-based micro- capsules to deliver and enhance the biological activity of compounds with therapeutic potential.
dc.identifier.citationUlusu, F., Bilgic, A., & Kursunlu, A. N. (2025). A half-natural origin approach for anticancer and antioxidant activities using sporopollenin and pillar[5]arene macroring. International Journal of Biological Macromolecules, 303, 140546. https://doi.org/10.1016/j.ijbiomac.2025.140546
dc.identifier.doi10.1016/j.ijbiomac.2025.140546
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid39894122
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2025.140546
dc.identifier.urihttps://hdl.handle.net/11492/10619
dc.identifier.volume303
dc.identifier.wosWOS:001423205300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorUlusu, Funda
dc.institutionauthorBilgiç, Ali
dc.institutionauthoridBilgiç, Ali/0000-0002-7055-0847
dc.institutionauthoridUlusu, Funda/0000-0002-0321-2602
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal Of Biological Macromolecule
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-cancer
dc.subjectAntioxidant
dc.subjectMicrocapsule
dc.subjectSporopollenin
dc.subjectPillar[5]arene
dc.titleA half-natural origin approach for anticancer and antioxidant activities using sporopollenin and pillar[5]arene macroring
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Bitkisel ve Hayvansal Üretim Bölümü Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Teknik Bilimler MYO, Mülkiyeti Koruma ve Güvenlik Bölümü,Makale Koleksiyonu