Determination of the effects of ankaferd wound dressing on the wound healing process in rats

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dc.contributor.authorŞensoy, Erhan
dc.contributor.authorGüneş, Eda
dc.contributor.authorErdal, Mehmet Okan
dc.date.accessioned2025-01-12T17:20:27Z
dc.date.available2025-01-12T17:20:27Z
dc.date.issued2024
dc.departmentKMÜ, Sağlık Bilimleri Fakültesi, Ebelik Bölümü
dc.description.abstractObjectives: The effects of a composite nanofiber wound dressing material consisting of a polyvinylidene alcohol and polyvinylidene pyrrolidone polymer mixture with a hemostatic agent doped with Ankaferd Blood Stopper (ABS) on the healing of experimentally induced dermal wounds in rats were examined. Materials and Methods: Rats were divided into 4 groups (n= 6). Histological material was examined on tissues taken from the wound site, whereas total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) analyses were performed on blood samples taken from the cardia. The material that was produced had hydrophilic properties, and both the ABS-doped and-undoped forms of the material positively affected wound healing. Results: In the histopathological examinations, macroscopic evaluations revealed a statistically significant difference between the groups in terms of wound diameter, reepithelialization, and inflammation formation ( p = 0.019). In parallel with wound healing and histological outcomes, TAS values increased in the ABS-doped groups, and TOS and OSI values decreased in the wound dressing groups ( p < 0.05). Conclusion: It was concluded that the ABS-dopped dressing did not have a negative effect on wound healing, it accelerated healing, and it could be used effectively and safely to treat skin injuries. However, further studies are needed to evaluate the clinical and histopathological benefits and potential adverse effects of wound dressings produced using ABS-doped polymers on wound healing.
dc.description.sponsorshipScientific Research Projects Commission of Karamanoglu Mehmetbey University [03-M-21]
dc.description.sponsorshipThis research was supported within the scope of the project numbered 03-M-21, which was accepted by the Scientific Research Projects Commission of Karamanoglu Mehmetbey University.
dc.identifier.citationŞensoy, E., Güneş, E., & Erdal, M. O. (2024). Determination of the effects of ankaferd wound dressing on the wound healing process in rats. Turkish Journal of Pharmaceutical Sciences, 21(2), 95–103. https://doi.org/10.4274/tjps.galenos.2023.03746
dc.identifier.doi10.4274/tjps.galenos.2023.03746
dc.identifier.endpage103
dc.identifier.issn1304-530X
dc.identifier.issn2148-6247
dc.identifier.issue2
dc.identifier.pmid38742756
dc.identifier.scopus2-s2.0-85195109162
dc.identifier.scopusqualityQ2
dc.identifier.startpage95
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2023.03746
dc.identifier.volume21
dc.identifier.wosWOS:001229186800007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞensoy, Erhan
dc.institutionauthoridŞensoy, Erhan/0000-0003-2989-459X
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnkaferd
dc.subjectNanofiber
dc.subjectWound
dc.subjectRat
dc.subjectOxidative stress index
dc.titleDetermination of the effects of ankaferd wound dressing on the wound healing process in rats
dc.typeArticle

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