The embryotoxic effects of in Ovo administered sunset yellow FCF in chick embryos

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dc.authorid0000-0003-0410-5523en_US
dc.authorid0000-0002-9915-3829en_US
dc.contributor.authorÇolakoğlu, Fatma
dc.contributor.authorSelçuk, Muhammet Lutfi
dc.date.accessioned2021-03-25T07:48:41Z
dc.date.available2021-03-25T07:48:41Z
dc.date.issued2021en_US
dc.departmentKMÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.descriptionWOS:000623303300001 PubMed ID: 33670635en_US
dc.description.abstractSunset yellow (SY) at prescribed concentrations has been approved by regulatory authorities in several countries as an additive dye in the food, beverage, cosmetic, and pharmaceutical industries. However, there are some reports that it may cause several health problems. The aim of this study is to evaluate embryotoxic effects of SY on liver and kidney in chick embryos. Babcock white Leghorn eggs were randomly divided into four groups. Non-treated eggs served as control group. The eggs in groups SY200, SY1000, and SY2000 were treated with a single injection of 200, 1000, and 2000 ng SY into the air sac just before incubation. The developmental stages of embryos were determined on the 10th, 13th, 16th, and 21st days of incubation. Samples of the liver and kidney were taken and routine histological procedures were performed. The highest relative embryo weight was seen in all SY treated groups on the 16th day of incubation. Necrosis of some hepatocytes and cytoplasmic degenerations were observed in all SY groups in the liver. There were degenerated or destructed renal cortex structures and necrosis in the kidney. The cell's nuclear areas and diameters of renal cortex structures were different in all SY groups compared to the control group (p < 0.05). It was concluded that in ovo administered SY has many unfavorable effects on liver and kidney in chick embryos. The results obtained in this study suggest that it may be advisable to re-assess safety levels of SY in many industries.en_US
dc.identifier.citationColakoglu, F.; Selcuk, M.L.(2021). The embryotoxic effects of in Ovo administered sunset yellow FCF in chick embryos. Veterinary Sciences, 8,2.en_US
dc.identifier.doi10.3390/vetsci8020031
dc.identifier.issn2306-7381
dc.identifier.issue2en_US
dc.identifier.pmid33670635
dc.identifier.scopus2-s2.0-85103473490
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/vetsci8020031
dc.identifier.urihttps://hdl.handle.net/11492/4950
dc.identifier.volume8en_US
dc.identifier.wosWOS:000623303300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇolakoğlu, Fatma
dc.language.isoen
dc.publisherMDPIen_US
dc.relation.journalVeterinary Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChicken_US
dc.subjectEmbryotoxic Effecten_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectSunset Yellowen_US
dc.titleThe embryotoxic effects of in Ovo administered sunset yellow FCF in chick embryosen_US
dc.typeArticle

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