Comparison of renal tubular damage with kidney ınjury molecule-1 in open and laparoscopic colorectal cancer surgery

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dc.contributor.authorDuyan, Abdullah Gürhan
dc.contributor.authorVatansev, Celalettin
dc.contributor.authorKocabaş, Rahim
dc.contributor.authorKoç, Melek Yalçın
dc.contributor.authorAkbulut, Muhammed Ai
dc.date.accessioned2025-03-17T10:40:18Z
dc.date.available2025-03-17T10:40:18Z
dc.date.issued2024
dc.departmentKMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground and Objectives: Colorectal cancer is the third most common type of cancer in men and women. With advancements in technology, minimally invasive treatment options have become increasingly prominent in colorectal cancer surgery. This study aimed to compare the increased intra-abdominal pressure in laparoscopic colon and rectal surgery with open procedures using kidney injury molecule-1 (KIM-1) secreted from renal tubules. Materials and Methods: We enrolled 46 patients diagnosed with colon cancer who underwent laparoscopic and open surgical procedures at our clinic. The patients were prospectively randomized into five groups: 10 laparoscopic right hemicolectomies (Group 1), 8 open right hemicolectomies (Group 2), 8 laparoscopic anterior resections (LARs) (Group 3), 11 open anterior resections (Group 4), and 9 laparoscopic low anterior resections (Group 5). Urine samples were collected from the patients preoperatively, postoperatively at the 4th hour, and postoperatively on the 14th day, and the urine KIM-1 levels and urine creatinine (Cr) values were measured. The urine KIM-1/Cr ratios were subsequently calculated. Results: The urinary KIM-1/Cr levels increased at the 4th postoperative hour after the open and laparoscopic procedures. On postoperative day 14, the urinary KIM-1/Cr levels were lower than those in the preoperative period in all groups, except the LAR group. Conclusions: Our study shown that the average pressure in laparoscopic colon and rectal surgery did not have a long-term impact on kidney injury in comparison to open colon and rectal surgery.
dc.identifier.citationDuyan AG., Vatansev C., Kocabaş R., Yalçın Koç M., Akbulut MA.. Comparison of Renal Tubular Damage with Kidney Injury Molecule-1 in Open and Laparoscopic Colorectal Cancer Surgery. Medicina (Kaunas). doi: 10.3390/medicina61010042. PMID: 39859024; PMCID: PMC11766636.
dc.identifier.doi10.3390/medicina61010042
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issn1010-660X
dc.identifier.issue1
dc.identifier.pmid39859024
dc.identifier.urihttps://doi.org/10.3390/medicina61010042
dc.identifier.urihttps://hdl.handle.net/11492/10647
dc.identifier.volume61
dc.identifier.wosWOS:001404419000001
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb Of Science
dc.institutionauthorKocabaş, Rahim
dc.institutionauthoridKocabaş, Rahim/0000-0001-8006-284X
dc.language.isoen
dc.publisherKaunas : Lietuvos gydytojų sąjunga
dc.relation.ispartofMedicina (Kaunas, Lithuania)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectkidney injury molecule-1
dc.subjectlaparoscopic colon and rectal surgery
dc.subjectrenal tubular damage
dc.titleComparison of renal tubular damage with kidney ınjury molecule-1 in open and laparoscopic colorectal cancer surgery
dc.typeArticle

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