The effect of preoperative carbohydrate-containing fluid consumption on maternal oxidative stress markers during elective cesarean delivery

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dc.contributor.authorDülger, Özlem
dc.contributor.authorBaşaran, Betül
dc.contributor.authorKorkusuz, Muhammet
dc.contributor.authorErel, Özcan
dc.contributor.authorNeşelioğlu, Salim
dc.contributor.authorOsmanoğlu, Usame Ömer
dc.contributor.authorSerin, Aliye Nigar
dc.date.accessioned2025-01-12T17:08:54Z
dc.date.available2025-01-12T17:08:54Z
dc.date.issued2024
dc.departmentKMÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentKMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose: The purpose of this study was to evaluate the effect of carbohydrate loading prior to the cesarean surgery under spinal anesthesia on thiols and ischemia-modified albumin (IMA) levels. Design: Prospective, randomized placebo-controlled study. Methods: Seventy-nine pregnant women planned for cesarean sections under spinal anesthesia at Karaman Training and Research Hospital were randomized into a control group (group C) (n = 42), and an oral carbohydrate preloading group (group OCH) (n = 37). OCH loading requires consuming 400 mL the night before surgery and 200 mL up to 2 hours before anesthesia. Group OCH consumed an oral carbohydrate-rich beverage (Nutricia-Fantomalt), and group C consumed an equal volume of water. This study investigated thiol-disulfide homeostasis after preoperative carbohydrate consumption. Preoperative gastric fluid, volume, antral cross-sectional area, hypotension following the birth, and fetal blood gas parameters were compared across groups. Findings: Thiols and IMA levels did not differ across groups before and after surgery (P > .05). Gastric ultrasonography showed similar antral cross-sectional area and stomach volume between groups (P = .172, P = .128, respectively). When surgery caused hypotension, group OCH received more ephedrine for surgery-induced hypotension, although this difference is not statistically significant (P = .704). A clustered error bar (95% confidence interval) plot with an interpolation line was used for a time-based comparison of mean differences in heart rate and mean arterial pressure between the groups. Conclusions: This study supports that mothers' thiols and IMA levels were unaffected by preoperative OCH loading before cesarean surgery. We did not examine thiol and its derivatives in umbilical cord blood; hence, we can not comment on thiol/disulfide homeostasis levels in neonates. © 2024 The American Society of PeriAnesthesia Nurses
dc.identifier.citationDülger, O., Başaran, B., Korkusuz, M., Erel, O., Neşelioğlu, S., Osmanoğlu, U. O., Serin, A. N., Kocabaş, R., Ecesoy, V., & Gören, M. A. (2025). The effect of preoperative carbohydrate-containing fluid consumption on maternal oxidative stress markers during elective cesarean delivery. Journal of PeriAnesthesia Nursing, 40(1), 22–29. https://doi.org/10.1016/j.jopan.2024.02.007
dc.identifier.doi10.1016/j.jopan.2024.02.007
dc.identifier.issn1089-9472
dc.identifier.pmid38878033
dc.identifier.scopus2-s2.0-85195639468
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11492/9092
dc.identifier.urihttps://doi.org/10.1016/j.jopan.2024.02.007
dc.identifier.wosWOS:001423118700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorDülger, Özlem
dc.institutionauthorBaşaran, Betül
dc.institutionauthorKorkusuz, Muhammet
dc.institutionauthorOsmanoğlu, Usame Ömer
dc.institutionauthorSerin, Aliye Nigar
dc.institutionauthoridBaşaran, Betül/0000-0001-5994-3861
dc.institutionauthoridOsmanoğlu, Usame Ömer/0000-0002-1198-2447
dc.institutionauthoridSerin, Aliye Nigar/0000-0003-0544-1115
dc.language.isoen
dc.publisherW.B. Saunders
dc.relation.ispartofJournal of Perianesthesia Nursing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIschemia-modified albümin
dc.subjectOxidative stress parameters
dc.subjectPregnant women
dc.subjectSpinal anesthesia
dc.titleThe effect of preoperative carbohydrate-containing fluid consumption on maternal oxidative stress markers during elective cesarean delivery
dc.typeArticle

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