Prognostic Implications and Predictors of Mitral Regurgitancy Reduction After Transcatheter Aortic Valve Implantation

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dc.contributor.authorGüney, Murat Can
dc.contributor.authorSüygün, Hakan
dc.contributor.authorPolat, Melike
dc.contributor.authorAyhan, Hüseyin
dc.contributor.authorKeleş, Telat
dc.contributor.authorBozkurt, Engin
dc.date.accessioned2025-01-12T17:09:37Z
dc.date.available2025-01-12T17:09:37Z
dc.date.issued2024
dc.departmentKMÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Mitral regurgitation (MR) is a common condition observed in patients undergoing transcatheter aortic valve implantation (TAVI) for the treatment of aortic stenosis (AS). However, the impact of TAVI on MR outcomes and the factors predicting MR improvement remains uncertain. Understanding these predictors can enhance patient management and guide clinical decisions. Methods: This retrospective cohort study included 156 patients with moderate to severe MR undergoing TAVI. MR severity was assessed via echocardiography at baseline, as well as 6 months and 1 year after TAVI. Patients were divided into groups based on MR reduction: no improvement or worsening, one-degree improvement, and at least two-degree improvement. Clinical, echocardiographic, and procedural characteristics were evaluated as predictive factors for MR improvement after TAVI. Results: MR reduction occurred in 68% of patients at 6 months and 81% at 1 year. Factors predicting a reduction of two grades or more in MR severity included lower baseline LVEDD (OR = 1.345, 95% CI: 1.112–1.628, p = 0.002) lower baseline LA (OR = 1.121, 95% CI: 1.015–1.237, p = 0.024), lower baseline LVMI (OR = 1.109, 95% CI: 1.020–1.207, p = 0.024), and higher baseline EF levels (OR = 1.701, 95% CI: 1.007–2.871, p = 0.047). No significant association was found between MR reduction at 6 months and one-year mortality. (p = 0.65). Conclusions: Baseline echocardiographic parameters are valuable in predicting MR improvement post-TAVI, with LVMI emerging as a novel predictor. However, MR reduction did not independently predict survival, underscoring the need for further research to optimize patient selection and management strategies in TAVI candidates. © 2024 by the authors.
dc.identifier.citationMurat Can Güney, Hakan Süygün, Melike Polat, Hüseyin Ayhan, Telat Keleş, Zeynep Şeyma Turinay Ertop, & Engin Bozkurt. (2024).Prognostic implications and predictors of mitral regurgitancy reduction after transcatheter aortic valve implantation. Medicina, 60(12), 2077. https://doi.org/10.3390/medicina60122077
dc.identifier.doi10.3390/medicina60122077
dc.identifier.issn1010-660X
dc.identifier.issue12
dc.identifier.pmid39768956
dc.identifier.scopus2-s2.0-85213472623
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11492/9315
dc.identifier.urihttps://10.3390/medicina60122077
dc.identifier.volume60
dc.identifier.wosWOS:001384661000001
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakPubMed
dc.institutionauthorSüygün, Hakan
dc.institutionauthoridSüygün, Hakan/0000-0001-8997-9240
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofMedicina (Lithuania)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmitral regurgitancy reduction
dc.subjectmortality
dc.subjectTAVI
dc.titlePrognostic Implications and Predictors of Mitral Regurgitancy Reduction After Transcatheter Aortic Valve Implantation
dc.typeArticle

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