Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model

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dc.contributor.authorÖztürk, Osman
dc.contributor.authorDikici, Yusuf
dc.contributor.authorGür, Öznur
dc.contributor.authorOcak, Mert
dc.contributor.authorDoğanyiğit, Züleyha
dc.contributor.authorOkan, Aslı
dc.contributor.authorSöylemez, Evrim Suna Arıkan
dc.date.accessioned2025-01-12T17:19:35Z
dc.date.available2025-01-12T17:19:35Z
dc.date.issued2024
dc.departmentKMÜ, Mühendislik Fakültesi, Makine Mühendisliği Bölümü
dc.departmentKMÜ, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractTartrazine, an azo dye prevalent in pharmaceuticals and food items, was investigated for its impact on fetal development, specifically examining visceral and skeletal abnormalities in rat offspring exposed to daily oral doses throughout pregnancy. Fourteen pregnant rats were randomly assigned to control and tartrazine groups (seven animals each), with tartrazine administered via oral gavage at 7.5 mg/kg throughout gestation. Offspring were categorized by gender for histopathological and genetic analysis of visceral structures. Bone quality and fracture resistance assessments involved micro-CT, Raman spectroscopy, and biomechanical testing. Results highlighted distinct internal organ tissue differences in the tartrazine group, notably increased hemorrhagic and inflammatory cell infiltration, degeneration, and vacuolization compared to controls. Gender-specific alterations in mRNA levels of IL-6, IL-1 beta, TNF-alpha, and TRPM2 genes (p < .001) were also noted. Moreover, tartrazine-exposed groups exhibited reduced trabecular thickness, bone volume, and significant alterations in bone matrix composition and quality alongside significant decreases in fracture resistance (p < 0.05). This study concludes that intrauterine exposure to tartrazine can result in adverse impacts on organ and bone development in rat offspring.
dc.identifier.citationÖztürk, O., Dikici, Y., Gür, Ö., Ocak, M., Doğanyiğit, Z., Okan, A., Arıkan Söylemez, E. S., Ateş, Ş., Uçar, S., Unal, M., & Yılmaz, S. (2024). Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model. Food Science & Nutrition, 12(11), 9162–9174. https://doi.org/10.1002/fsn3.4485
dc.identifier.doi10.1002/fsn3.4485
dc.identifier.endpage9174
dc.identifier.issn2048-7177
dc.identifier.issue11
dc.identifier.pmid39619970
dc.identifier.scopus2-s2.0-85205254961
dc.identifier.scopusqualityQ1
dc.identifier.startpage9162
dc.identifier.urihttps://doi.org/10.1002/fsn3.4485
dc.identifier.urihttps://hdl.handle.net/11492/10093
dc.identifier.volume12
dc.identifier.wosWOS:001320251700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Sceince
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGür, Öznur
dc.institutionauthorÜnal, Mustafa
dc.institutionauthoridGür, Öznur/0000-0003-0175-9433
dc.institutionauthoridÜnal, Mustafa/0000-0002-9518-8952
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAzo dye
dc.subjectBone microstructure
dc.subjectBone quality
dc.subjectRaman spectroscopy
dc.subjectTartrazine
dc.titleEvaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model
dc.typeArticle

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